Naganishia albida

Synonymy:
Cryptococcus albidus, Cryptococcus diffluens

Naganishia albida  infections in humans are rare. 

Impaired cellular immunity is the most common risk factor with HIV infection and low CD4 counts a common comorbidity.

RG-1 organism.

Culture: 
Colonies (SDA) are cream-coloured smooth, mucoid, glabrous, yeast-like.

Microscopy: 
Globose to ovoid budding yeast-like cells, 3.5-8.8 x 5.5-10.2 μm. Pseudohyphae are absent.

India ink preparation: 
Positive - distinct thin capsules are present.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose v L-Arabinose + D-Glucitol +
Fermentation   Sucrose + D-Arabinose v 𝝰-M-D-Glucoside v
Glucose - Maltose + D-Ribose v D-Gluconate +
Galactose - Cellobiose + L-Rhamnose v DL-Lactate v
Sucrose - Trehalose +,w D-Glucosamime - myo-Inositol +
Maltose - Lactose v N-A-D-glucosamine - 2-K-D-Gluconate +
Lactose - Melibiose v Glycerol v D-Glucuronate +
Trehalose - Raffinose + Erythritol v Nitrate +
Assimilation   Melezitose + Ribitol v Urease +
Glucose + Soluble Starch v Galactitol v 0.1% Cycloheximide -
Galactose v D-Xylose + D-Mannitol + Growth at 37C v

Key features: 
Naganishia albida has variable growth at 37C. 

Antifungal susceptibility: Naganishia albida (Australian national data); MIC µg/mL. 

Antifungal No ≤0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 ≥64
AMB 1           1            
FLU 1                     1  
VORI 1           1            
POSA 1           1            
ITRA 1                        
5FC 1                       1