BIOCHEM 3000 - Molecular and Structural Biology III
North Terrace Campus - Semester 1 - 2014
General Course Information
Course Code BIOCHEM 3000 Course Molecular and Structural Biology III Coordinating Unit School of Molecular and Biomedical Science Term Semester 1 Level Undergraduate Location/s North Terrace Campus Units 6 Contact Up to 14 hours per week Prerequisites BIOCHEM 2500 & BIOCHEM 2501 or BIOCHEM 2504 & BIOCHEM 2505 or BIOCHEM 2502 Course Description This course aims to extend the discussions of protein structure and function presented in the Biochemistry Level II courses and to use this knowledge to gain an understanding of some of the essential processes of molecular biology. The course covers two principle themes: Protein Structure and Function: topics include - structure and function of different classes of proteins, protein folding, targeted protein degradation, the development of new therapies, molecular interactions and recognition. The Control of Gene Expression: topics include; genetic circuits and synthetic biology; chromatin structure and its remodelling during transcription; the recruitment and assembly of transcription factors and the RNA polymerase complex on a gene promoter; artificially manipulating gene expression with the use of "designer genes" and synthetic transcription factors; eukaryote mRNA synthesis, processing, modification, stability and translation, and manipulation of these processes to effect selective gene expression. This course combines lectures and tutorials with cutting edge research-based practical exercises to complement the lecture material.
Course Coordinator: Dr Tony Fratini
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Understanding aspects of protein structure and function including protein folding, degradation, development of new therapies, molecular interactions and recognition. 2 Understanding aspects of the control of gene expression including genetic circuits, chromatin structure and remodelling, gene promoter assembly, eukaryotic mRNA synthesis, processing and translation. 3 Understanding key experimental processes required to evaluate protein structure, function and gene expression, and knowledge of how to apply them to solve specific biochemical problems. 4 Specific skills in planning, performing, interpreting, quantitatively analysing and communicating biochemical research using a variety of modern experimental techniques. 5 Ability to find, read, interpret and critically analyse relevant scientific literature. 6 Ability to work in teams and communicate scientific outcomes.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Knowledge and understanding of the content and techniques of a chosen discipline at advanced levels that are internationally recognised. 1, 2, 3 The ability to locate, analyse, evaluate and synthesise information from a wide variety of sources in a planned and timely manner. 3, 4, 5 An ability to apply effective, creative and innovative solutions, both independently and cooperatively, to current and future problems. 4, 5, 6 Skills of a high order in interpersonal understanding, teamwork and communication. 6 A proficiency in the appropriate use of contemporary technologies. 1, 2, 3, 4 A commitment to continuous learning and the capacity to maintain intellectual curiosity throughout life. 3, 4, 5, 6 A commitment to the highest standards of professional endeavour and the ability to take a leadership role in the community. 5, 6 An awareness of ethical, social and cultural issues within a global context and their importance in the exercise of professional skills and responsibilities. 4, 6
Required ResourcesLaboratory coat, safety glasses and closed shoes.
Recommended ResourcesText book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
Online LearningResource material such as lecture, tutorial, practical and past exams will be available on Myuni.
Online assessment will be conducted via Myuni.
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
3 Lectures of 1 hour each per week by the Academic research staff.
1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.
1 Practical of 15 hours per fortnight. (Odd weeks = 5 hours & Even weeks = 10 hour
duration). Includes 2 oral presentations in weeks 6, 12/13, with immediate feedback provided.
3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediate
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.
Type Number of sessions Duration of each session (hr) Total hours Lectures 36 1 36 Tutorials 12 1 12 Practicals 18 5 90 Exam 1 3 3 Type
Number of sessions
Expected preparation time (hr) Total hours Laboratory report 2 5 10 Presentation 2 2 4 Summative Tests 3 1 3 Type Number of sessions Expected preparation time (hr) Total hours Weekly reading 36 2 72 Tutorial preparation 12 1 12 Practical preparation 15 1 15 Test preparation 3 2 6 Exam preparation 1 48 48
Learning Activities Summary
Topic Lecture 1 Protein Life Cycle Lecture 2 Introduction to Macromolecular X-ray Crystallography Lecture 3 Applications of Structural Biology Lecture 4 Protein-nucleic Acid Interactions Lecture 5 Genetic Circuts and Synthetic Biology Lecture 6 Proteomics Lecture 7 Chromatin Remodelling and Transcriptional Control Lecture 8 Chromatin Remodelling and Transcriptional Control Lecture 9 How Transcription Factors are Regulated to Control Complex Promoters Lecture 10 How Transcription Factors are Regulated to Control Complex Promoters Lecture 11 RNA Processing Lecture 12 RNA Processing Lecture
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Task Type Due Weighting Learning Outcome Written exam on lecture material Summative
65% 1, 2, 3 Practical write up on research project Formative and Summative week 6 and 12 30% 4, 5 Online assessments Formative and Summative weeks 4, 8 and 12 5% 1, 2, 3
Assessment Related RequirementsAttendance and active participation at all practicals is mandatory.
Assessment DetailEnd of term Exam (65% of total course grade): A 3 hour examination covering the lecture material. It is made up of short and long answer type questions.
Practical (30% of total course grade): The semester long practical exercise will include experimental work, keeping an up to date laboratory notebook, 2 oral presentations and the submission of a final
practical report. The two oral presentations are each 10-15 minutes, cover the research performed in the practical, and performed in small groups in weeks 6, 12/13. Students receive feedback throughout the semester on laboratory performance and keeping of laboratory notebooks immediately after each oral presentation, and on the final report. Outstanding students may have the option of a laboratory-based research project in place of the practical exercise.
Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (5% of total course grade). Encourages revision of the material soon after the relevant lectures and immediate feedback provided to students. This is done outside of contact time.
No information currently available.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
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The assessor usually provides appropriate feedback of assessment tasks to the student by means of written comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
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