MICRO 3001 - Infection and Immunity IIIB
North Terrace Campus - Semester 2 - 2020
General Course Information
Course Code MICRO 3001 Course Infection and Immunity IIIB Coordinating Unit School of Biological Sciences Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 6 Contact Up to 19 hours per fortnight Available for Study Abroad and Exchange Y Prerequisites MICRO 2501 or MICRO 2505 or equivalent Incompatible MICRO 3202 Assumed Knowledge MICRO 3000 Course Description This is an advanced course in immunology and virology. The course includes detailed examination of the cellular and molecular biology of the immune system, immune responses to microbial pathogens and other antigenic stimuli and immunisation against infections in humans and animals. Detailed attention will be given to major virus infections and typical host immune responses, the experimental models used to study viruses and antiviral therapies including chemotherapies and vaccination. Topics to be covered include: differentiation and activation of leukocytes; functions of leukocyte subsets; cell biology of antigen processing and presentation; molecular recognition of antigen; molecular and cellular bases of inflammation; signal transduction in immune cells; characteristics and functions of cytokines; mechanisms of immunoregulation; cellular communication and leukocyte traffic through tissues; production and use of monoclonal antibodies; local immunity at mucosal surfaces; immunity to infectious agents, including bacteria, viruses and parasites; inflammatory and autoimmune diseases such as asthma and arthritis; control and prevention of infections; strategies for the design and use of vaccines and gene therapy; important diseases will be considered as specific examples. Viruses to be studied will include examples chosen from those responsible for hepatitis, human immunodeficiency, respiratory and gastrointestinal infections and diseases of the skin and nervous systems.
Course Coordinator: Professor Shaun McColl
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Gained an understanding of the molecular and cellular mechanisms that underpin the pathogenesis and control of infections, and the interaction of pathogens with the immune system. 2 Gained a body of experimental skills and techniques frequently used in research in immunology and virology, which are fundamental to understanding how research in these disciplines is conducted. 3 Developed essential skills in experimental design, techniques and execution, which are relevant to immunology & virology and many other areas of scientific research. 4 Developed organisational and time management skills and the capacity for multi-tasking. 5 Developed the ability to work in small teams and to communicate and coordinate outcomes with a larger group of colleagues.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
1,2,3 Critical thinking and problem solving
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
1,2,3 Teamwork and communication skills
- developed from, with, and via the SGDE
- honed through assessment and practice throughout the program of studies
- encouraged and valued in all aspects of learning
1,2,3,4,5 Career and leadership readiness
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
1,2,3,4,5 Intercultural and ethical competency
- adept at operating in other cultures
- comfortable with different nationalities and social contexts
- able to determine and contribute to desirable social outcomes
- demonstrated by study abroad or with an understanding of indigenous knowledges
2,3,4,5 Self-awareness and emotional intelligence
- a capacity for self-reflection and a willingness to engage in self-appraisal
- open to objective and constructive feedback from supervisors and peers
- able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
No textbook is currrently recommended. Please refer to MyUni for recommended reading.
An essential component of the physical fabric is a large modern and well-equipped teachinglaboratory,
designed and maintained for advanced practical experiments. This laboratory can be at most only marginally removed from research standard and in should be in close proximity to a world-class research environment such as that available within the fabric of the School of Molecular and Biomedical Science. This close juxtaposition of research and undergraduate education is entirely in keeping with the aspirations of a research-intensive university where active research informsand stimulates in the classroom.
Online LearningTeaching materials and course documentation will be posted on the MyUni website (http://myuni.adelaide.edu.au/).
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered in the following means:
3 x 1 hour lectures per week,
1 x 2 hour tutorials (total of 3 sessions)
3 x 5 hours practical per fortnight
Practical sessions of 5 hours on
Wednesday and Thursday afternoons in odd weeks and 5 hours in even weeks.
Practicals include: wet lab sessions.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities SummaryThe course content will include the following:
Lecture topics to be covered include:
differentiation and activation of leukocytes; functions of leukocyte subsets; cell biology of antigen processing and presentation; molecular recognition of antigen; molecular and cellular bases of inflammation; signal transduction in immune cells; characteristics and functions of cytokines; mechanisms of immunoregulation; cellular communication and leukocyte traffic through tissues; production and use of monoclonal antibodies; local immunity at mucosal surfaces; immunity to infectious agents, including bacteria, viruses and parasites; inflammatory and autoimmune diseases such as asthma and arthritis; control and prevention of infections; strategies for the design and use of vaccines and gene therapy; important diseases will be considered as specific examples.
Each student will participate in the presentation of research paper tutorials. Research paper tutorials are compulsory and assessable - all students will be expected to attend and contribute in every session scheduled for their group. In each session, two to three students will present the paper and lead the discussion. Each student will be involved in the presentation of a single paper, but will be expected to participate in the discussion of all other papers.
Tutorials will be conducted via Zoom
Practicals will utilise a number of specific experimental protocols to demonstrate important aspects of immunology and virology, including experiments that reinforce the theory aspects of the course, relevant basic and advanced experimental techniques and technologies and basic understanding of the experimental basis of scientific knowledge, including experimental design. The practical course will also instil skills required to address scientific problems in a team environment.
Working on alternatives but intend to use every available time slot for face to face practicals, albeit with reduced numbers of students present and compensate for lost prac time with alternatives.
A 2000 word essay that will develop familiarity with the primary research literature and the processes of communicating scientific information by written publication and develop skills in scientific inquiry through reading and written interpretation of primary and secondary research literature.
Specific Course RequirementsSafety equipment for practicals: Laboratory coat and protective glasses.
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Task Type Due Weighting Learning Outcome Practical
laboratory calculations and concept orientation
0% 1-3 Early
Formative & Summative Week 4 7.5% 2,3 Final laboratory workbook submission Summative Week 8 7.5% 2,3 Practical Exam Summative Week 9 10% 2,3 Essay Summative Mid semester break 15% 1,4 Tutorials Summative Week 4-8 15% 1,4,5 Written exam Summative Exam period 45% 1
Assessment DetailFinal Exam (45% of course grade)
One exam will be given to test the capacity to comprehend and integrate knowledge from a broad range of topics relevant to the disciplines of immunology & virology.
1/3 of the marks will be longer essay format
2/3rd of the marks will be short answer or similar questions.
Tutorials (15% of course grade)
Small groups of students will analyse and reflect on key primary research papers relevant to the lecture course,
The tutorials assess knowledge of scientific concepts, techniques and technologies, cognitive skills, critical thinking and presentation skills.
Assessment will be based on individual performance and participation
Practicals (25% of course)
Assessment will be by a combination of activities that include one or more of the following:
1) Practical Exam
A series of questions are used to promote reading of the manual and the theory
behind the methods and reagents used.
2) Daybook – marked twice
This is used to record all experimental work and results. It is used to write
the experimental reports.
Students submit an essay of 2,000 words (maximum) on an allocated topic of relevance to the
disciplines of immunology and virology. Students are expected to read widely on the topic and to cover the most up-to-date primary literature.
SubmissionIf an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e.
weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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This section contains links to relevant assessment-related policies and guidelines - all university policies.
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