BIOCHEM 3001 - Cancer, Stem Cells & Development III
North Terrace Campus - Semester 2 - 2022
General Course Information
Course Code BIOCHEM 3001 Course Cancer, Stem Cells & Development III Coordinating Unit School of Biological Sciences Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 6 Contact 3 x 1 hour lectures per week, 1 x 1 hour tutorial per week, 3 x 5 hour practical per fortnight for the semester (total 11.5 hrs/week) Available for Study Abroad and Exchange Y Prerequisites BIOCHEM 2500 & BIOCHEM 2501 or BIOCHEM 2502 & BIOCHEM 2503 Incompatible BIOCHEM 3520, BIOCHEM 3235 Course Description This Capstone course combines lectures and tutorials with cutting edge research-based practical exercises. The lecture material covers major conceptual and technical advances in this field, focussing on two principle themes:
1. Molecular Basis of Cancer: topics include the molecular mechanisms of cell-cell communication, signal transduction pathways, genetic mutations, oncogenes and tumour suppressor genes, clonal selection, the hallmarks of cancer and metastasis, dysregulation of cell cycle checkpoints, DNA damage, replicative senescence, telomere shortening and genomic instability, control of cell proliferation and apoptosis, cancer-specific metabolism and oncometabolites. Specific examples are included of current of diagnostic and therapeutic approaches for cancer.
2. Stem Cells and Development: topics include the embryonic and adult stem cells, cellular reprogramming and induced pluripotent stem cells (iPS), generation of transgenic/knock-out mice using CRISPR/Cas9 and other techniques, with medical and other applications. Finally, the topics of cell differentiation, neurogenesis and exploring neural circuits will be covered.
The practical component involves a research-based practical project using CRISPR/Cas9 technology in the first seven weeks of the semester to complement the lecture material, with an individually written essay on a specific research topic in the final five weeks of the semester.
Course Coordinator: Associate Professor Dan Peet
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Understand key theoretical aspects of the regulation of cellular signalling, proliferation and differentiation in the context of embryonic development, stem cells and diseases such as cancer. 2 Understand and apply advanced experimental techniques required to solve specific biochemical problems, and understand of the ethical implications of this research. 3 Plan, perform, interpret, and quantitatively analyse biochemical research using a variety of modern experimental techniques 4 Find, interpret and critically analyse relevant scientific literature and apply it to specific problems in biochemical research. 5 Work in teams and communicate scientific outcomes
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s)
Attribute 1: Deep discipline knowledge and intellectual breadth
Graduates have comprehensive knowledge and understanding of their subject area, the ability to engage with different traditions of thought, and the ability to apply their knowledge in practice including in multi-disciplinary or multi-professional contexts.
1, 2, 3
Attribute 2: Creative and critical thinking, and problem solving
Graduates are effective problems-solvers, able to apply critical, creative and evidence-based thinking to conceive innovative responses to future challenges.
3, 4, 5
Attribute 3: Teamwork and communication skills
Graduates convey ideas and information effectively to a range of audiences for a variety of purposes and contribute in a positive and collaborative manner to achieving common goals.
4, 5, 6
Attribute 4: Professionalism and leadership readiness
Graduates engage in professional behaviour and have the potential to be entrepreneurial and take leadership roles in their chosen occupations or careers and communities.
Attribute 5: Intercultural and ethical competency
Graduates are responsible and effective global citizens whose personal values and practices are consistent with their roles as responsible members of society.
Attribute 7: Digital capabilities
Graduates are well prepared for living, learning and working in a digital society.
3, 4, 5
Attribute 8: Self-awareness and emotional intelligence
Graduates are self-aware and reflective; they are flexible and resilient and have the capacity to accept and give constructive feedback; they act with integrity and take responsibility for their actions.
Required ResourcesLaboratory coat, safety glasses and closed shoes.
Recommended ResourcesText book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
Online LearningResource material such as lecture, tutorial, practical and past exams will be available on Myuni.Online assessment will be conducted via Myuni.
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
3 Lectures of 1 hour each per week by the Academic research staff.
1 Tutorial of 1 hour per week developing material covered in lectures.
1 Practical of 15 hours per fortnight. (Odd weeks = 5 hours & Even weeks = 10 hour duration) during the first seven weeks of the semester.
1 essay topic: 7 regular practical sessions are set aside for students to research and prepare a specific essay topic.
3 online multiple choice tests of 1 hour duration per semester.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary
Schedule Week 1 Mechanisms of epigenetic cell memory Lecture Week 2 Signalling domains: structure and function Lecture Week 3 Signalling domains: structure and function Lecture Week 4 Cell signalling pathways Lecture Week 5 Cancer molecular biology Lecture Week 6 Cancer molecular biology Lecture Week 7 Cancer and metabolism Lecture Week 8 mTOR signalling in cancer Lecture Week 9 Stem cells/CRISPR technology Lecture Week 10 Bowel cancer, stem cells & the tumour microenvironment Lecture Week 11 Neurogenesis, and exploring neuronal circuits Lecture Week 12 Neurogenesis, and exploring neuronal circuits Lecture
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Task Type Due Weighting Learning Outcome Written test on lecture material Summative
20% 1, 2, 3 Written exam on lecture material Summative
45% 1, 2, 3 Practical research project Formative/Summative end of week 7 15% 4, 5 Essay research topic Summative end of week 12 15% 4, 5 Online assessment Formative/Summative weeks 4, 8 and 12 5% 1, 2, 3
Assessment Related RequirementsAttendance and active participation at all practicals is mandatory.
Assessment DetailOnline practical exercise (6% of total course grade): Design of tools for CRISPR, including gRNAs, PCR primers, antibodies etc. during allotted practical sessions.
Mid-semester test (20% of total course grade): A 1 hour written test held in week 6, covering the first 4 weeks of lecture material, short and long answer type questions.
Online multiple choice quizzes (5% of total course grade): Three multiple choice tests in weeks 5, 9 and 12 . Encourages revision of the material soon after the relevant lectures, and immediate feedback provided to students.
Practical performance and report (12% of total course grade): The seven week long practical exercise will include experimental work, keeping an up to date laboratory notebook, and a final poster presentation in week 7.
Outstanding students may have the option of a laboratory-based research project in place of the practical exercise.Essay (12% of total course grade): Students will write an essay of up to 2500 words on a one of the offered topics in cutting edge biochemical research.
End of semester written exam: (45% of total course grade) – 2.5 hour written examination covering the lecture material, short and long answer type questions.
SubmissionIf an extension is not applied for, or not granted,then a penalty for late submission
will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.Provision of Feedback to StudentsThe assessor usually provides appropriate feedback of assessment tasks to the student by means ofwritten comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
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