BIOCHEM 3225 - Advanced Molecular Biology IIIB (Biochemistry)
North Terrace Campus - Semester 2 - 2014
General Course Information
Course Code BIOCHEM 3225 Course Advanced Molecular Biology IIIB (Biochemistry) Coordinating Unit School of Molecular and Biomedical Science Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 6 Contact Up to 23 hours per fortnight Prerequisites BIOCHEM 2510, BIOCHEM 2520, BIOCHEM 2102 & BIOCHEM 2202 Incompatible BIOCHEM 3001 & GENETICS 3210 Assumed Knowledge BIOCHEM 3125 Restrictions Available to BSc(MolBiol) students only Course Description This course covers the regulation of cellular signalling, proliferation and differentiation in the context of embryonic development and diseases such as cancer. Lectures provide detailed information on the major conceptual and technical advances in this field, focussing on two principle themes: 1. The Molecular Basis of Cancer: topics include molecular mechanisms underlying normal cell-cell communication, signal transduction pathways, cell proliferation and apoptosis, differentiation, intracellular compartments, the cytoskeleton and cell shape, adhesion and migration. 2. Stem Cells and Development: topics include embryonic and adult stem cells, cellular reprogramming, induced pluripotent stem cells (iPS), transgenic and knock-out mice, differentiation, neurogenesis, morphogenesis, segmentation and body plan, growth factors in development, sex determination and medical applications. This course combines these lectures and tutorials from Cancer, Stem Cells and Development III (BIOCHEM 3001) with practical exercises and/or laboratory placements in professional research laboratories. It includes a specialised set of Problem Based Learning (PBL) exercises, which are designed to provide students with a perspective of how cutting edge molecular biology principles and techniques are applied to major research questions. The PBL segment of the course may include aspects of biochemistry, genetics, microbiology, immunology and chemistry. This course will illustrate that cross-disciplinary approaches are essential in modern research.
Course Coordinator: Dr Tony Fratini
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Understanding aspects of the molecular basis of cancer. 2 Understanding key aspects of stem cells, celldifferentiation and development in lower eukaryotes and vertebrates. 3 Understanding key experimental processes required to evaluate molecular aspects of stem cells, cancer and development, knowledge of how to apply them to solve specific biochemical problems, and an understanding of the ethical implications of this research. 4 Advanced skills and experience in planning, performing, interpreting, quantitatively analysing and communicating biochemical research using a variety of modern experimental techniques. 5 Ability to find, read, interpret, and critically analyse relevant scientific literature and apply it to specific problems in molecular biology. 6 Ability to work in teams and communicate scientific outcomes.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Knowledge and understanding of the content and techniques of a chosen discipline at advanced levels that are internationally recognised. 1, 2, 3 The ability to locate, analyse, evaluate and synthesise information from a wide variety of sources in a planned and timely manner. 3, 4, 5 An ability to apply effective, creative and innovative solutions, both independently and cooperatively, to current and future problems. 4, 5, 6 Skills of a high order in interpersonal understanding, teamwork and communication. 6 A proficiency in the appropriate use of contemporary technologies. 1, 2, 3, 4 A commitment to continuous learning and the capacity to maintain intellectual curiosity throughout life. 3, 4, 5, 6 A commitment to the highest standards of professional endeavour and the ability to take a leadership role in the community. 5, 6 An awareness of ethical, social and cultural issues within a global context and their importance in the exercise of professional skills and responsibilities. 4, 6
Required ResourcesLaboratory coat, safety glasses and closed shoes.
Recommended ResourcesText book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
Online LearningResource material such as lecture, tutorial, practical and past exams will be available on Myuni. Online assessment will be conducted via Myuni.
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
3 Lectures of 1 hour each per week. The stacked / same time teaching components are thelectures timetabled with the existing course, Cancer, Stem Cells and Development III (BIOCHEM 3001).
1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.
1 Laboratory-based research project (45 hours) or CSCDIII Practical of (15 hours per fortnight, odd weeks = 5 hours & even weeks = 10 hour duration) in weeks 1-6. Includes oral presentation
in week 6 with immediate feedback provided.
1 x 2 hour problem-based learning (PBL) exercise weeks 7-12. Involves two different PBLs based on current research and bioethics, each assessed by 10-15 minute presentation in small groups.
3 online multiple choice tests of 1 hour duration (weeks 4, 8 and 12, with immediate feedback
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary
Schedule Week 1 Signalling Domains: Structure and Function Lecture Week 2 Signal Transduction in Normal Growth and Cancer Lecture Week 3 Cancer: Cell Proliferation/Survival Lecture Week 4 Cancer: Cell Cycle/Apoptosis Lecture Week 5 Cancer Lecture Week 6 Cancer: Adhesion/Migration Lecture Week 7 Cancer: Adhesion/Migration Lecture Week 8 Cancer and Metabolism Lecture Week 9 Axis Determination and Positional Information in Embryos Lecture Week 10 Stem Cells Lecture Week 11 Cell Differentiation/Neurogenesis Lecture Week 12 Sex Determination Lecture
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Task Type Due Weighting Learning Outcome Written exam on lecture material Summative
End of semester
65% 1, 2, 3
Formative and Summative End of week 7 15% 4, 5 PBL exercises Formative and Summative End of week 13 15% 5, 6
Formative and Summative Weeks 4. 8 and 12 5% 1, 2, 3
Assessment DetailEnd of term Exam (65% of total course grade) – A 3 hour examination covering the lecture material. It is made up of a mixture of short and long answer type questions.
Laboratory placement/Practical (15% of total course grade). The half semester research project (students can choose a laboratory placement or CSCDIII practical) will include experimental work,
keeping an up to date laboratory notebook, 1 oral presentation and the submission of a final practical report. The oral presentation is 10-15 minutes, cover the research performed in the practical, and performed individually (research placement) or small groups (CSCDIII practical) in week 7. Students
receive feedback throughout the semester on laboratory performance and keeping of laboratory notebooks, as well as immediately after the oral presentation, and on the final report.
PBL exercises (15% of total course grade), including assessment via oral presentations, weeks 7-12: Involves two different PBLs based on current research, each assessed by 10-15 minute presentation in small groups.
Online exercises (3 per semester): Three multiple choice tests in weeks 4, 8 and 12 (5% of total course grade). Encourages revision of the material soon after the relevant lectures, and immediate feedback provided to students.
No information currently available.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.Provision of Feedback to Students
The assessor usually provides appropriate feedback of assessment tasks to the student by means of written comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
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