GENETICS 3210 - Advanced Molecular Biology IIIB (Genetics)
North Terrace Campus - Semester 2 - 2017
General Course Information
Course Code GENETICS 3210 Course Advanced Molecular Biology IIIB (Genetics) Coordinating Unit School of Biological Sciences Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 6 Contact Up to 12 hours per week Available for Study Abroad and Exchange N Prerequisites BIOCHEM 2510 & BIOCHEM 2520 & GENETICS 2510 & GENETICS 2520 Incompatible Genetics 3211 and Genetics 3212 and Genetics 3520 Restrictions Available to BSc(MolBiol) students only Course Description The material taught in this courses is organised around the theme of genes ? how genes function and their roles in development and disease. The aim is to give students an appreciation, at an advanced level, of the mechanisms that control gene expression, the genetic determination of developmental pathways, the various types of human genetic mutation that lead to disease and the pathogenic pathways from genotype to phenotype. The practical component of the course will extend students? familiarity with various laboratory and/or analytical techniques used in human and developmental genetics. It includes a specialised set of Problem Based Learning (PBL)/Tutorial exercises, which are designed to provide students with a perspective of how cutting edge molecular biology principles and techniques are applied to major research questions. The PBL segment of the course may include aspects of biochemistry, genetics, microbiology, immunology and chemistry. This course will illustrate that cross-disciplinary approaches are essential in modern research.
Course Coordinator: Associate Professor Michael Lardelli
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
The course aims to give students a level of understanding of concepts and experimental techniques in the areas of gene regulation, developmental genetics and human genetics that would enable them to develop competencies expected of a university graduate in Genetics. The course cannot hope to cover comprehensively the very broad range of research questions in these areas but it will give students understanding of specific exemplary questions and provide them with knowledge of how they can extend their learning as required by future studies and employment. The practical aspect of the course aims to equip students with sufficient fundamental skills to apply them to a broad range of positions requiring these skills. The Problem Based Learning (PBL) exercises aim to give students a perspective of how cutting edge molecular biology principles and techniques are applied to major research questions.
The anticipated knowledge, skills and/or attitude to be developed by the student are:
1 Understanding of the underlying conceptual framework regarding the regulation of genes and how research expands our knowledge in this area 2 Understanding of the underlying conceptual framework regarding how genes control embryo development and how research expands our knowledge in this area 3 Understanding of the underlying conceptual framework regarding human genetics and how research expands our knowledge in this area 4 Comprehension of scientific research data described in peer-reviewed journals 5 Recording of laboratory research notes and analysis and reporting of experimental data 6 The ability to extract relevant information from literature databases and to present it in written form 7 To provide students with the opportunity to derive and interpret novel experimental outcomes in a supportive environment commensurate with their capabilities as a final year candidates for the Degree of Bachelor of Science (Molecular Biology).
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
1, 2, 3, 4, 5, 6, 7 Critical thinking and problem solving
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
4, 5, 6, 7 Teamwork and communication skills
- developed from, with, and via the SGDE
- honed through assessment and practice throughout the program of studies
- encouraged and valued in all aspects of learning
7 Career and leadership readiness
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
4, 5, 6, 7 Self-awareness and emotional intelligence
- a capacity for self-reflection and a willingness to engage in self-appraisal
- open to objective and constructive feedback from supervisors and peers
- able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
4, 5, 6, 7
This course will require the following texts and other resources:
· Text for Human Genetics lectures: 'Human Molecular Genetics - 4th Edition' by Strachan and Read.
· Copies of scientific papers for Gene Regulation and Developmental Genetics aspects of the course (supplied by the lecturers)
· Collaborating research laboratories
· Scientific equipment
· Lecture theatres and tutorial rooms
· Access to University Library
· Access to computers and internet including a portable internet-capable device for workshops
· Students must supply laboratory coat and safety glasses for their own use
Learning & Teaching Activities
Learning & Teaching Modes
This course will be delivered by the following means:
“Pre-workshop” material in the form of pre-recorded lectures or assigned reading material etc. 10 hours per week (includes revision of delivered material).
4 workshops of 1 hour each per week. Each week will include one 20 minute in-workshop summative test.
12 hours of practical laboratory/placement per fortnight (weeks 1-6)
(Note: Students who do not obtain a laboratory placement will perform the normal Practical course of Genetics 3211 in weeks 1-6)
6 PBL sessions of up to 5 hours per week in weeks 7-12.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary
Type of learning activity Topic Week 1 Pre-workhop material Developmental Neurogenetics Worskhop Developmental Neurogenetics Practical Laboratory Placement or Developmental Genetics Practical Week 2 Pre-workhop material Developmental Neurogenetics Worskhop Developmental Neurogenetics Practical Laboratory Placement or Developmental Genetics Practical Week 3 Pre-workhop material Developmental Neurogenetics Worskhop Developmental Neurogenetics Practical Laboratory Placement or Developmental Genetics Practical Week 4 Pre-workhop material Developmental Genetics Worskhop Developmental Genetics Practical Laboratory Placement or Developmental Genetics Practical Week 5 Pre-workhop material Regulation of Gene Expression / Epigenetics Worskhop Regulation of Gene Expression / Epigenetics Practical Laboratory Placement or alternative practical work Week 6 Pre-workhop material Regulation of Gene Expression / Epigenetics Worskhop Regulation of Gene Expression / Epigenetics Practical Laboratory Placement or alternative practical work Week 7 Pre-workhop material Regulation of Gene Expression / Epigenetics and Cancer Genetics Worskhop Regulation of Gene Expression / Epigenetics and Cancer Genetics Practical Problem Based Learning Exercises Week 8 Pre-workhop material Plant Developmental Genetics Worskhop Plant Developmental Genetics Practical Problem Based Learning Exercises Mid Semester Break Week 9 Pre-workshop material Human Genetics Worskhop Human Genetics Practical Problem Based Learning Exercises Week 10 Pre-workhop material Human Genetics Worskhop Human Genetics Practical Problem Based Learning Exercises Week 11 Pre-workhop material Human Genetics Worskhop Human Genetics Practical Problem Based Learning Exercises Week 12 Pre-workhop material Human Genetics Worskhop Human Genetics Practical Problem Based Learning Exercises Week 13* Pre-workhop material Worskhop Practical
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment task Type of assessment Percentage of total assessment for grading purposes # Hurdle
Yes or No #
Outcomes being assessed / achieved In-Workshop Tests Formative / Summative 15% No 1, 2, 3, 4 Final Examination Summative 40% No 1, 2, 3, 4 Laboratory Placement/Practical Formative / Summative 25% No 4, 5, 6, 7 PBL Formative / Summative 20% No 4, 6, 7
Assessment DetailLaboratory Placement (25% of total course grade, learning objectives 4, 5, 6, 7) - comprised of one 10-15 minute oral presentation (5%), laboratory performance (7.5%) and written practical report (12.5%) in weeks 1-6. Marked Practical Reports will be handed in at the end of week 6 and promptly assessed by mentors/demonstrators to provide feedback to students and a sense of progressive accomplishment in the course. Students who do not obtain a laboratory placement will perform the normal Practical course of Genetics 3211 for weeks 1-6 and will be assessed as for that course.
PBL exercises, including assessment via 2 small group oral presentations, weeks 7-12: (20% of total course grade, learning objectives 4, 6, 7). Each individual in the PBL group marked separately.
Examinations in workshops (15% of course grade, Learning Objectives 1, 2, 3, 4). The final third of one workshop session per week (any of the four sessions per week) will be devoted to answering a series of questions assessing material in that and previous workshops and the pre-workshop material. This will test and reinforce students’ understanding of the course material. To avoid problems with students occasionally missing workshops, students’ final accumulated mark for these examinations will be made up of their best 8 scores (from the possible 12 examinations).
Final examination (40% of course grade, learning objectives 1, 2, 3, 4). This will be a three hour examination assessing any/all theoretical aspects of the course. The examination includes compulsory areas but also a limited choice of questions within each compulsory area.
SubmissionDetails on submission are provided in the Course Handbook and/or Practical manuals etc.
Late submission of assessments:
If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days or more late without an approved extension can only receive a maximum of 50% of the mark.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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