GENETICS 3211 - Gene Expression & Human Developmental Genetics III
North Terrace Campus - Semester 2 - 2017
General Course Information
Course Code GENETICS 3211 Course Gene Expression & Human Developmental Genetics III Coordinating Unit School of Biological Sciences Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 6 Contact Up to 12 hours per week Available for Study Abroad and Exchange Y Prerequisites GENETICS 2510 & GENETICS 2520 or equivalent Incompatible GENETICS 3210, GENETICS 3212 Course Description The material taught in this courses is organised around the theme of genes ? how genes function and their roles in animal and plant development and disease. The aim is to give students an appreciation, at an advanced level, of the mechanisms that control gene expression, the genetic determination of developmental pathways, the various types of human genetic mutation that lead to disease and the pathogenic pathways from genotype to phenotype. The practical component of the course will extend students? familiarity with various laboratory and/or analytical techniques used in human and developmental genetics through a number of laboratory and scientific literature research projects.
Course Coordinator: Associate Professor Michael Lardelli
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning OutcomesThe course aims to give students a level of understanding of concepts and experimental techniques in the areas of gene regulation, developmental genetics and human genetics that would enable them to develop competencies expected of a university graduate in Genetics. The course cannot hope to cover comprehensively the very broad range of research questions in these areas but it will give students understanding of specific exemplary questions and provide them with knowledge of how they can extend their learning as required by future studies and employment. The practical aspect of the course aims to equip students with sufficient fundamental skills to apply them to a broad range of positions requiring these skills.
The anticipated knowledge, skills and/or attitude to be developed by the student are:
1. Understanding of the underlying conceptual framework regarding the regulation of genes and how research expands our knowledge in this area
2. Understanding of the underlying conceptual framework regarding how genes control embryo development and how research expands our knowledge in this area
3. Understanding of the underlying conceptual framework regarding human genetics and how research expands our knowledge in this area
4. Comprehension of scientific research data described in peer-reviewed journals
5. Recording of laboratory research notes and analysis and reporting of experimental data
6. The ability to extract relevant information from literature databases and to present it in written or oral form
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
1, 2, 3, 4, 5, 6 Critical thinking and problem solving
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
4, 5, 6 Career and leadership readiness
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
4, 5, 6 Self-awareness and emotional intelligence
- a capacity for self-reflection and a willingness to engage in self-appraisal
- open to objective and constructive feedback from supervisors and peers
- able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
4, 5, 6
Required ResourcesThis course will require the following texts and other resources:
Text for Human Genetics lectures: 'Human Molecular Genetics - 4th Edition' by Strachan
Copies of scientific papers for Gene Regulation and Developmental Genetics aspects of the
course (supplied by the lecturers)
Collaborating research laboratories
Practical manuals (if doing the practical. These are supplied by lecturers running each
Practical Laboratories (if doing the practical)
Lecture theatres and tutorial rooms
Access to University Library
Access to computers and internet including to a portable, internet capable device during workshops.
Students must supply laboratory coat and safety glasses for their own use
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
“Pre-workshop” material in the form of pre-recorded lectures or assigned reading material etc. 10 hours per week (includes revision of delivered material).
4 workshops of 1 hour each per week. Each week will include one 20 minute in-workshop summative test.
12 hours of laboratory/other practical work per fortnight.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., workshops and practicals), as well as non-contact time (e.g., pre-workshop reading and revision etc.).
Learning Activities Summary
Week Type of Learning Activity Topic 1 Pre-workshop material Developmental Neurogenetics Workshop Developmental Neurogenetics Practical Developmental Genetics (Drosophila and zebrafish) 2 Pre-workshop material Developmental Neurogenetics Workshop Developmental Neurogenetics Practical Developmental Genetics (Drosophila and zebrafish) 3 Pre-workshop material Developmental Neurogenetics Workshop Developmental Neurogenetics Practical Developmental Genetics (Drosophila and zebrafish) 4 Pre-workshop material Developmental Genetics Workshop Developmental Genetics Practical Additional Developmental Genetics time if needed 5 Pre-workshop material Regulation of Gene Expression / Epigenetics Workshop Regulation of Gene Expression / Epigenetics Practical Epigenetics and Plant Transgenics 6 Pre-workshop material Regulation of Gene Expression / Epigenetics Workshop Regulation of Gene Expression / Epigenetics Practical Epigenetics and Plant Transgenics 7 Pre-workshop material Regulation of Gene Expression / Epigenetics and Cancer Genetics Workshop Regulation of Gene Expression / Epigenetics and Cancer Genetics Practical Epigenetics and Plant Transgenics 8 Pre-workshop material Plant Developmental Genetics Workshop Plant Developmental Genetics Practical Epigenetics and Plant Transgenics Mid Semester Break 9 Pre-workshop material Human Genetics Workshop Human Genetics Practical Human Molecular Genetics: Positional Cloning of Human Genetic Diseases Presentation and Scientific Paper Interpretation Exercises 10 Pre-workshop material Human Genetics Workshop Human Genetics including Cancer Genetics Practical Human Molecular Genetics: Positional Cloning of Human Genetic Diseases Presentation and Scientific Paper Interpretation Exercises 11 Pre-workshop material Human Genetics Workshop Human Genetics including Cancer Genetics Practical Human Molecular Genetics: Positional Cloning of Human Genetic Diseases Presentation and Scientific Paper Interpretation Exercises 12 Pre-workshop material Human Genetics Workshop Human Genetics including Cancer Genetics Practical Human Molecular Genetics: Positional Cloning of Human Genetic Diseases Presentation and Scientific Paper Interpretation Exercises 13* Pre-workshop material Workshop Practical
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Type of Assessment Percentage of total assessemnt for grading purposes Hurdle
Outcomes being assessed/achieved In-Workshop Assessments Formative/Summative 15% No 1, 2, 3, 4 Research Report I Formative/Summative 15% No 1, 4, 5, 6 Research Report II Formative/Summative 15% No 2, 4, 5, 6 Literature Review & Presentation Summative 15% No 3, 4, 6 Final Examination Summative 40% No 1, 2, 3, 4
Assessment Detail*Research Report I (conducted within a 4 week period) – gene regulation (15% of course grade) 3% of the 15% is awarded for written answers to questions requiring internet, other literature research or reading the practical manual. The remaining 12% of the 15% is awarded for a scientific report. (Summative and possibly formative assessment depending on when the task is conducted*.)
*Research Report II– developmental genetics (15% of course grade). 3-4.5% of the 15% is awarded for written answers to questions requiring internet and other literature research. 10.5-12% of the 15% is awarded after completion of the laboratory-based practical work for the quality of the written experimental notes and answers to questions included within the experimental handbook. (Summative and possibly formative assessment depending on when the task is conducted*.)
Literature review and presentation (15% of course grade) Students must extract information from a scientific journal paper and translate this into a description of the research and conclusions that is understandable by an informed layman. Written and/or oral presentation of the information is possible. Students are assessed on the content and delivery of the information. (Summative and possibly formative assessment depending on when the task is conducted*.)
* Each of the three assessed components above is conducted over a 4 week period. However, the order of the components may vary from year to year.
Examinations in workshops (15% of course grade, Learning Objectives 1, 2, 3, 4). The final third of one workshop session per week (any of the four sessions per week) will be devoted to answering a series of questions assessing material in that and previous workshops and the pre-workshop material. This will test and reinforce students’ understanding of the course material. To avoid problems with students occasionally missing workshops, students’ final accumulated mark for these examinations will be made up of their best 8 scores (from the possible 12 examinations).(Formative and summative assessment.)
Final examination (40% of course grade, Learning Objectives 1, 2, 3, 4). This will be a three hour examination assessing any/all theoretical aspects of the course. The examination includes compulsory areas but also a limited choice of questions within each compulsory area. (Summative assessment)
SubmissionSubmission of Developmental Genetics Practical workbooks is into the submission box at the front desk of the Molecular Life Sciences Building. Submission of other essays is via MyUni and will include checking for plagiarism by Turnitin. Details on submission are provided in the Course Handbook and/or Practical manuals etc.
Late submission of assessments
If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days or more late without an approved extension can only receive a maximum of 50% of the mark.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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