PATHOL 3200 - Neurological Diseases

North Terrace Campus - Semester 2 - 2014

The aim of this course is to provide students with an understanding of a range of diseases and conditions affecting the central and peripheral nervous systems. General topics covered include the causes and consequences of raised intracranial pressure, headache, infections, tumours and dementia, as well as more specific disorders such as epilepsy and multiple sclerosis. Traumatic brain and spinal cord injury, stroke and the effects of alcohol and illicit drugs on the brain will also be discussed. The practical classes provide an opportunity for students to examine macroscopic and microscopic specimens illustrating selected pathologies covered in lectures as well as work in teams for the group assessment tasks.

  • General Course Information
    Course Details
    Course Code PATHOL 3200
    Course Neurological Diseases
    Coordinating Unit Anatomy and Pathology
    Term Semester 2
    Level Undergraduate
    Location/s North Terrace Campus
    Units 3
    Contact Up to 5 hours per week
    Prerequisites PATHOL 2200, ANAT SC 2109 or ANAT SC 2500 or PHYSIOL 2510 or PHYSIOL 2520 or equivalent
    Course Description The aim of this course is to provide students with an understanding of a range of diseases and conditions affecting the central and peripheral nervous systems. General topics covered include the causes and consequences of raised intracranial pressure, headache, infections, tumours and dementia, as well as more specific disorders such as epilepsy and multiple sclerosis. Traumatic brain and spinal cord injury, stroke and the effects of alcohol and illicit drugs on the brain will also be discussed. The practical classes provide an opportunity for students to examine macroscopic and microscopic specimens illustrating selected pathologies covered in lectures as well as work in teams for the group assessment tasks.
    Course Staff

    Course Coordinator: Associate Professor Corinna Van Den Heuvel

    Course Coordinator: Associate Professor Corinna Van Den Heuvel
    Phone: +61 8 8313 1456
    Email: corinna.vandenheuvel@adelaide.edu.au
    Location: Room N305a, Medical School North

    Course Coordinator: Dr Renee Turner
    Phone: +61 8 8313 3114
    Email: renee.turner@adelaide.edu.au
    Location: Room 524, Medical School South

    Lecturer: Professor Roger Byard
    Email: roger.byard@adelaide.edu.au

    Lecturer: Dr Emma Thornton
    Email: emma.thornton@adelaide.edu.au

    Lecturer: Dr Janet Coller
    Email: janet.coller@adelaide.edu.au

    Lecturer: Dr Mark Hutchinson
    Email: mark.hutchinson@adelaide.edu.au

    Lecturer: Professor Simon Koblar
    Email: simon.koblar@adelaide.edu.au

    Lecturer: Dr Ian Johnson
    Email: ian.johnson@adelaide.edu.au
    Course Timetable

    The full timetable of all activities for this course can be accessed from Course Planner.

  • Learning Outcomes
    Course Learning Outcomes
    1 Understand essential basic pathological processes including inflammation, atherosclerosis and neoplasia
    2 Acquire the ability to relate these basic pathological processes to the pathogenesis of common and important diseases
    3 Gain knowledge and understanding of the predisposing factors, causes, pathogenesis, morphology, potential complications and how they arise, natural history of, and the main symptoms and signs of such diseases
    4 Correlate clinical features with causes and mechanisms of disease
    5 Understand how knowledge of pathological processes can be utilised in the investigation, management and prevention of disease
    6 Use and understand terminology for the field of study correctly and contextually
    7 Ability to verbally present a scientific topic to an audience of peers
    8 Acquire, read, interpret and synthesise information from a wide variety of sources in a planned and timely manner
    9 Acknowledge and reference sources of information appropriately
    10 Work in groups and individually in the pursuit of scientific knowledge
    University Graduate Attributes

    This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:

    University Graduate Attribute Course Learning Outcome(s)
    Knowledge and understanding of the content and techniques of a chosen discipline at advanced levels that are internationally recognised. 1-8
    The ability to locate, analyse, evaluate and synthesise information from a wide variety of sources in a planned and timely manner. 6, 8, 9
    An ability to apply effective, creative and innovative solutions, both independently and cooperatively, to current and future problems. 6-8
    Skills of a high order in interpersonal understanding, teamwork and communication. 10
    A proficiency in the appropriate use of contemporary technologies. 7, 9, 10
    A commitment to continuous learning and the capacity to maintain intellectual curiosity throughout life. 1-8
    A commitment to the highest standards of professional endeavour and the ability to take a leadership role in the community. N/A
    An awareness of ethical, social and cultural issues within a global context and their importance in the exercise of professional skills and responsibilities. N/A
  • Learning Resources
    Required Resources
    None.
    Recommended Resources
    Recommended textbooks are:
    Robbins and Cotran Pathologic Basis of Disease, 8th edition, 2009 by Kumar, Abbas, Fausto, and Aster published by Elsevier Saunders.
    OR
    Rubin's Pathology, Clinicopathologic Foundations of Medicine, 6th edition, 2011 by Rubin, and Strayer (eds), published by Lippincott Williams and Wilkins.

    Pathology Museum
    To further your understanding of pathology, and in particular the macroscopic changes of disease in various tissues, it is recommended that you utilise the collection of specimens in the Hans Schoppe Pathology Museum, room N318 on the 3rd floor of the north wing of the Medical School North building.

    The specimens are grouped in organ systems and there are accompanying catalogues that provide clinical information, a description and diagnosis for each specimen. Sample specimens of common and important pathologies are also highlighted in the catalogues. It is useful to examine a number of examples of a particular condition to gain a better understanding, since disease, like the people it affects, is highly variable. Examples of different pathologies can be found using the index. You may find it beneficial to use pathology and other textbooks (e.g. anatomy) when studying in the museum. Please return specimens to their appropriate position on the shelves following their use. The catalogues are not to be removed from the museum.

    The Hans Schoppe Museum is open during normal working hours (approx. 8.30am–4.30pm each weekday) but will be closed during examination periods. It is not a common room and eating, smoking and drinking are not allowed. It is only for the use of students enrolled in courses in which pathology is studied and students should demonstrate a professional respectful attitude when using it. Photography is strictly forbidden and specimens cannot be removed from the museum without the consent of the Head of Discipline.

    The rules of the museum are stated in a notice on the front door. Any student caught breaking the rules will face disciplinary action.

    If you have difficulties in understanding a specimen, do not hesitate to ask one of the academic staff for help.
    Online Learning
    My Uni
    All course correspondence including important course information and regular announcements will take place through MyUni. All lecture notes, practical class notes, lecture audio recordings etc are available on MyUni.

    Web sites
    There is a wide range of pathology orientated web sites. These contain tutorials, images of macroscopic and microscopic pathology and links to a range of related sites. A selection of web addresses follows.

    http://www.pathguy.com
    http://medicalstudent.com/
    http://medicalstudent.com/
    http://www.med.unsw.edu.au/pathology/pathmus/
    http://www.med.unsw.edu.au/pathology/pathmus/
    https://www.med.illinois.edu/m2/pathology/PathAtlasf/titlepage.html
    https://www.med.illinois.edu/m2/pathology/PathAtlasf/titlepage.html
    http://www-medlib.med.utah.edu/WebPath/webpath.html
    http://www-medlib.med.utah.edu/WebPath/webpath.html
    http://www.pathmax.com/main.html
    http://www.pathmax.com/main.html
    http://peir.net/
    http://peir.net/
    http://pathweb.uchc.edu/
    http://pathweb.uchc.edu/
    http://alf3.urz.unibas.ch/pathopic/e/intro.htm
    http://alf3.urz.unibas.ch/pathopic/e/intro.htm
    http://www.pathology.vcu.edu/education/education.html

    School of Medical Sciences web pages
    A variety of resource material, including the catalogues for the Pathology Museum, is available via
    the School of Medical Sciences web pages
    https:// health.adelaide.edu.au/medical-sciences/current-students/pathresources/.
    A student identification number is required for access.
  • Learning & Teaching Activities
    Learning & Teaching Modes
    Lectures are supported by interactive tutorials designed to develop and clarify topics covered in lectures. These are generally problem-solving sessions and may include discussion of potential examination questions and answers. Practical classes are designed to provide students with an opportunity to further explore the macroscopic and microscopic features of pathological processes related to important diseases covered in lectures, as well as to protect time for completion of assessment tasks such as assignments and preparation of oral presentations. Some of these sessions will also be used to provide regular feedback to students about assessment tasks.
    Workload

    The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

    The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

    As a 3 unit course, Neurological Diseases will require approximately 12 h of work per week, including lecture and tutorial attendance, completion of assignments, preparation of the oral presentation and private study. Since the assignments and the oral presentation are each worth 10-15% of the overall assessment, it is expected that students will spend approximately 15-20 hours on each task.
    Learning Activities Summary
    Please note that this timetable has been adapted from 2013 and is still not finalised. It will only be finalised in May 2014 so will be updated then.

    NEUROLOGICAL DISEASES TIMETABLE 2014
    Lectures: Mondays @ 1pm and 2pm in Medical School South, S127.
    Group Study Time: Mondays 3pm-4pm, Medical School South, S127.
    Large Group Tutorials: Tuesdays 12pm-1pm, Medical School South, S127.

    Wk

    Date

    Activity

    Lecturer

    Assignment

    1

    Mon 28 July - 1pm

    Lecture 1 - Traumatic brain injury

    Prof. Bob Vink

    Mon 28 July - 2pm

    Lecture 2 - Spinal cord injury

    Dr Anna Leonard

    Mon 28 July - 3pm

    Introduction to tutorials, reserved study times and assessment

    BV

    Tues 29 July - 12pm

    Large group tutorial session

    BV

    2

    Mon 4 Aug - 1pm

    Lecture 3 - Cerebral oedema and ICP

    BV

    Mon 4 Aug - 2pm

    Lecture 4 - Cerebrovascular disease

    Dr Renee Turner

    Mon 4 Aug - 3pm Reserved Study Time
    Tues 5 Aug - 12pm Large group tutorial session BV
    3 Mon 11 Aug - 1pm Lecture 5 - Neurotransmitter disorders BV
    Mon 11 Aug - 2pm Lecture 6 - Parkinson's disease Dr Emma Thornton
    Mon 11 Aug - 3pm Reserved Study Time
    Tues 12 Aug - 12pm Large group tutorial session BV
    4 Mon 18 Aug - 1pm Lecture 7 - Stem cells in neurological diseases Prof. Simon Koblar Assignment 1 available
    Mon 18 Aug - 2pm Lecture 8 - Nociceptors and pain BV
    Mon 18 Aug - 3pm Reserved Study Time
    Tues 19 Aug - 12pm Large group tutorial session BV
    5 Mon 25 Aug - 1pm Lecture 9 - Neuroinflammation Dr Mark Hutchinson
    Mon 25 Aug - 2pm Lecture 10 - Neuroinflammation and pain MH
    Mon 25 Aug - 3pm Reserved Study Time - finalise oral presentation topics Presentation topic approval deadline
    Tues 26 Aug - 12pm Large group tutorial session MH
    6 Mon 1 Sep - 1pm Lecture 11 - Migraine BV Assignment 1 due (5pm)
    Mon 1 Sep - 2pm Lecture 12 - Neuropathology of SIDS Prof. Roger Byard
    Mon 1 Sep - 3pm Reserved Study Time
    Tues 2 Sep - 12pm Large group tutorial session BV
    7 Mon 8 Sep - 1pm Lecture 13 - Neurobiological basis of addiction BV Assignment 2 available
    Mon 8 Sep - 2pm Lecture 14 - Alzheimer's Disease A/Prof. Van Den Heuvel
    Mon 8 Sep - 3pm Reserved Study Time
    Tues 9 Sep - 12pm Large group tutorial session CVDH
    8 Mon 15 Sep - 1pm Lecture 15 - Cerebral infections CVDH
    Mon 15 Sep - 2pm Lecture 16 - Multiple sclerosis CVDH
    Mon 15 Sep - 3pm Reserved Study Time
    Tues 16 Sep - 12pm Large group tutorial session CVDH
    --- Sep 22 - Oct 3 Mid-semester break --- ---
    9 Mon 6 Oct Public Holiday
    Tues 7 Oct - 12pm Reserved Study Time Assignment 2 due (5pm)
    10 Mon 13 Oct - 1pm Lecture 18 - Peripheral nervous systems disorders Dr Ian Johnson
    Mon 13 Oct - 2pm Lecture 19 - Motor Neurone Disease IJ
    Mon 13 Oct - 3pm Reserved Study Time
    Tues 14 Oct - 12pm Large group tutorial session IJ
    11 Mon 20 Oct - 1pm Lecture 20 - Brain tumours Dr Elizabeth Harford-Wright
    Mon 20 Oct - 2pm Lecture 21 - Genetic influences on neurological disorders Dr Janet Coller
    Mon 20 Oct - 3pm Reserved Study Time
    Tues 21 Oct - 12pm Large group tutorial session JC & EHW
    12 Mon 27 Oct - 1pm Oral presentations (S127) CDVH, BV Oral presentations
    Mon 27 Oct - 2pm Oral presentations (S127) CDVH, BV Oral presentations
    Mon 27 Oct - 3pm Oral presentations (S127) CDVH, BV Oral presentations
    Tues 28 Oct - 12pm Oral presentations (S127)

    Presentation feedback; exam outline
    CDVH, BV Oral presentations
  • Assessment

    The University's policy on Assessment for Coursework Programs is based on the following four principles:

    1. Assessment must encourage and reinforce learning.
    2. Assessment must enable robust and fair judgements about student performance.
    3. Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
    4. Assessment must maintain academic standards.

    Assessment Summary
    Assessment Task Assessment Type Weighting Learning Outcome(s) being addressed
    2 x written assignments Summative 30% 6, 8-10
    Presentation Summative 10% 7-10
    End of semester examination comprising practical (20%) and theory (35%) components Summative 60% 1-6, 8
    Assessment Related Requirements
    In order to pass Neurological Diseases, students are required to have completed all components of the assessment and students must achieve a grade of at least 40% in the end of semester theory examination, and achieve an overall grade of at least 50% for the course.

    Students failing to meet these requirements may either fail outright or be required to sit supplementary examinations.
    Assessment Detail
    Assessment comprises several parts:

    ·    Take home assignments. There will be 2 assignments contributing a total of 30% toward your final grade. Due dates are indicated on the course schedule both in this document and downloadable from MyUni.

    ·    An on-course assignment/presentation worth 10% of your final grade. Students working in groups of ideally 3 (no exceptions) will present a powerpoint presentation on a topic selected form a provided list. No topic can be presented by more than one group of students. Peer assessment will account for 5% of the grade, while academic assessment will account for 5% (a total of 10%)

    ·     An end of semester examination comprising 60% of your final grade. The end of semester examination will comprise a 3-hour written paper. The examination will aim to examine the depth of a student’s understanding of the topics that have been covered during the semester (both lectures and tutorials) in addition to factual knowledge. This will involve extensive reading and study, rather than just learning lecture handouts



    All assessments are summative. Assignments and examinations will be graded using marks. The total possible mark for each will be specified on the assignment/examination.

    Referencing in assignments
    To avoid plagiarism, the answers should be written in your own words and should be referenced where appropriate. It is not appropriate to use sentences straight from a textbook, journal article or website, or even to just reorganise a sentence or change a few words from information in a textbook, journal article or website. Information obtained from reference sources should be extensively rewritten to demonstrate your understanding of the topic.
     
    Appropriate referencing is important for academic integrity. It is important that the contribution of the work of others is acknowledged, it provides evidence to support your argument and it provides evidence that you are not plagiarising. The reader should be able to consult the exact source of your information if they wish. You should ensure that your reference includes the information that you are stating it contains. When using a journal article as a reference, you should have read the entire article, not just the abstract.
     
    All sources used for obtaining information should be referenced, including lecture notes and web sites. Each reference must be indicated in the text and in a reference list at the end of the assignment. When referencing use the Harvard style, by citing the first author (followed by et al if there are also others) and the year of publication in the text and putting the references in alphabetical order by first author in a references section at the end of the assignment.  Page numbers containing information obtained from books, in addition to journals, should be stated.
     
    References should conform to the following style (Harvard style):
     
    Books: Fishman AP: Pulmonary Hypertension and Cor Pulmonale. Pulmonary Diseases and Disorders. Edited by Fishman AP. New York, McGraw-Hill, 1988, pp. 999-1048
    Journals: Meyrick B, Reid L: Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression. Am J Pathol 1980, 100:151-178
     
    You may use non-peer reviewed websites (e.g. Wikipedia) to aid your research for assignments, but be aware that such websites do not necessarily contain reliable accurate or sufficiently detailed information. Use of such websites as references in assignments is strongly discouraged and should be kept to a minimum. However, if websites are used, they should be referenced in a similar style to that above, including the authors name, name of the article and website and web address.

    Mark penalties may be applied for inappropriate referencing in assignments. This may include being awarded 0 marks for the assignment. Unacceptable practices in addition to frank plagiarism include presenting information without appropriate attribution to the original source and students separately submitting the same or very similar pieces of work with the intention to deceive the assessor as to the contribution they have made to the assessment work (collusion).

    Please ensure that you have read the University’s Policies on Plagiarism and Cheating in Examinations and Related Forms of Assessment. It is each student’s responsibility to read and follow the instructions distributed by the university, school and discipline, including course guides and those related to assessment tasks. These include referencing requirements. Ignorance of appropriate practices, carelessness in note taking and referencing, and finishing an assignment in a hurry are not excuses for inappropriate referencing. For those students requiring further information on this topic, a good powerpoint presentation can be downloaded from http://www.adelaide.edu.au/professions/hub/downloads/plagiarism-referencing-tutorial.ppt .


    PENALTIES
    Penalties will apply for late submission of assignments unless an extension with appropriate reasons and supporting documentation (e.g. medical certificate) is provided to the course coordinator BEFORE the due date and time of submission. Otherwise, submission up to 3 days late will result in a loss of 50% of your assignment mark and submission later than this will result in no marks being awarded. Only significant circumstances, such as the death of a close relative or friend, major psychological difficulties or major changes in personal circumstances beyond the control of the student will be considered in the granting of extensions for compassionate reasons .
    Submission
    Submission of the assignments is through TURNITIN on MyUni.

    Generally there is a 2-3 week turnaround time for staff to mark assessment pieces. We will endeavour to return work with appropriate feedback as quickly as possible. If a student requires further clarification and feedback they can contact the course coordinator.

    Penalties will apply for late submission of assignments unless an extension with appropriate reasons and supporting documentation (e.g. medical certificate) is provided to the course coordinator BEFORE the due date and time of submission.

    Otherwise, submission up to 3 days late will result in a loss of 50% of your assignment mark and submission later than this will result in no marks being awarded. Only significant circumstances, such as the death of a close relative or friend, major psychological difficulties or major changes in personal circumstances beyond the control of the student will be considered in the granting of extensions for compassionate reasons.
    Course Grading

    Grades for your performance in this course will be awarded in accordance with the following scheme:

    M10 (Coursework Mark Scheme)
    Grade Mark Description
    FNS   Fail No Submission
    F 1-49 Fail
    P 50-64 Pass
    C 65-74 Credit
    D 75-84 Distinction
    HD 85-100 High Distinction
    CN   Continuing
    NFE   No Formal Examination
    RP   Result Pending

    Further details of the grades/results can be obtained from Examinations.

    Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

    Final results for this course will be made available through Access Adelaide.

    REPLACEMENT/ADDITIONAL ASSESSMENT

    On Medical or Compassionate Grounds
    To request a replacement/additional assessment on Medical or Compassionate grounds, appropriate forms should be obtained from your faculty office or the appropriate web site, completed and submitted in the appropriate time frame. Students are advised to refer to the university’s policy on examinations (see below). Academic staff will make the final decision regarding the offer of a replacement/additional assessment. Sitting a replacement/additional assessment is offered on this basis will result in a formal mark being awarded, i.e. pass, credit or distinction. Both written theory and practical replacement/additional assessments may be offered.

    http://www.adelaide.edu.au/student/exams/supps.html

    On Academic Grounds
    Replacement/additional assessments will be offered to selected students on academic grounds.
    Those sitting these will be required to achieve a grade of at least 50% in either a written theory examination, written practical examination or both, depending on which of the examinations the student did not meet the necessary requirement to pass the course, and obtain an overall mark of at least 50% for the course. Successful completion of supplementary examinations offered on this basis can only result in a final mark for the course of 50%.

    http://www.adelaide.edu.au/student/exams/supps.html

    Examinations are timetabled by the university and held during the official university examination periods and students are expected to be available to sit examinations at these times. Students who fail to sit on the set date and time without satisfactory medical or compassionate reasons submitted in writing in the appropriate time frame, will be deemed to have failed Essentials of Pathology. Only one sitting for replacement/additional assessment is offered.

    Examinations WILL NOT be rescheduled for students on holidays or away attending weddings etc.
    Information provided in applications for replacement/additional assessments or extensions for assignments will be treated in confidence.
  • Student Feedback

    The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

    SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

  • Student Support
  • Policies & Guidelines
  • Fraud Awareness

    Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student’s disciplinary procedures.

The University of Adelaide is committed to regular reviews of the courses and programs it offers to students. The University of Adelaide therefore reserves the right to discontinue or vary programs and courses without notice. Please read the important information contained in the disclaimer.