CHEM 2524 - Chemistry IIB (Molecular and Drug Design)
North Terrace Campus - Semester 2 - 2014
General Course Information
Course Code CHEM 2524 Course Chemistry IIB (Molecular and Drug Design) Coordinating Unit School of Chemistry & Physics Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 3 Contact Up to 7.5 hours per week Prerequisites CHEM 1100 & CHEM 1200 or CHEM 1101, CHEM 1201 & CHEM 1312 Incompatible CHEM 2520, CHEM 2522, CHEM 2526 Assumed Knowledge CHEM 2514 Restrictions Available to B Sc (Molecular & Drug Design) students only Course Description Studies in Chemistry at Level II deal with a range of fundamental concepts that can be used to explain various phenomena in chemistry, biology and materials science. The courses have been designed to provide students who have an interest in chemistry with the necessary knowledge and skills to undertake further studies in chemistry or pursue alternative pathways in the biological, environmental, earth and physical sciences.
Chemistry IIB focuses on structure determination and the spectroscopic and geometric properties of molecules, and how these influence reactivity. The examples used to illustrate these points draw on expertise in atomic and molecular spectroscopy, symmetry, and organic synthesis.
Course Coordinator: Associate Professor Tak Kee
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
- identify likely candidates in the characterisation using symmetry arguments;use
- molecular orbital theory to describe chemical bonding in complicated
- molecules that are not adequately explained by less advanced theories;
- identify symmetry elements and point groups of molecules;
- predict likely spectral characteristics of given molecular species;
- solve the structures of unknown molecules using the techniques of NMR spectroscopy and mass spectrometry;
- determine whether a molecule is aromatic;define electrophilic aromatic substitution and nucleophilic aromatic substitution;
- propose synthetic routes to a variety of molecules, starting from simple precursors;
- use important quantum models including particle-in-a-box, rigid rotor, and harmonic oscillator to elucidate molecular motions;
- design, conduct, analyse and interpret results of an experiment, and effectively communicate these in written reports.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Knowledge and understanding of the content and techniques of a chosen discipline at advanced levels that are internationally recognised. 1-9 The ability to locate, analyse, evaluate and synthesise information from a wide variety of sources in a planned and timely manner. 1, 2, 3, 6, 7, 8 An ability to apply effective, creative and innovative solutions, both independently and cooperatively, to current and future problems. 2, 4, 5, 8, 9, 10 Skills of a high order in interpersonal understanding, teamwork and communication. 10 A proficiency in the appropriate use of contemporary technologies. 10 A commitment to continuous learning and the capacity to maintain intellectual curiosity throughout life. 1 – 9 A commitment to the highest standards of professional endeavour and the ability to take a leadership role in the community. 1 – 10 An awareness of ethical, social and cultural issues within a global context and their importance in the exercise of professional skills and responsibilities. 10
‘Pushing Electrons’ (Weeks, 3rd Edition, Harcourt College Publishers, 1998)
- ‘Organic Chemistry’ (Bruice, 5th Edition, Pearson Education, 2007)
- ‘Organic Chemistry’ (Clayden, Greeves, Warren and Wothers, Oxford University Press, 2000)
- ‘Modern Physical Organic Chemistry’ (Anslyn and Dougherty, University Science Books, 2005)
- ‘Inorganic Chemistry’ (Shriver & Atkins, 4th Edition, Oxford University Press, 2006)
- ‘Physical Chemistry’ (Atkins, 8th Edition, Oxford University Press, 2006)
- ‘Physical Chemistry’ (Tinoco, 4th Edition, Prentice Hall, 2002)
All the above are available for purchase from UniBooks or for loan from the Barr Smith library. Some are also available for consultation in the Chemistry Resource Centre (Rm 120, Johnson Laboratories)
MyUni: Teaching materials and course documentation will be posted on the MyUni website (http://myuni.adelaide.edu.au/).
Learning & Teaching Activities
Learning & Teaching Modes
Lectures 36 x 50-minute sessions with three sessions per week
Tutorials 12 x 50-minute sessions with one session per week
Practicals 8 x 5-hour sessions
Specialist Tutorials 5 x 1-hour sessions with one session per week for 5 weeks
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.
A student enrolled in a 3 unit course, such as this, should expect to spend, on average 12 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary
The course content includes the following:
Applications of Symmetry
This section of the course will introduce students to symmetry operations and elements, point groups and applications of symmetry (e.g. chiralilty, polarity, and IR spectroscopy). Use of ligand field theory. Symmetry aspects in construction of MO orbital diagrams, pi-acceptor ligands, electronic configuration versus molecular geometry, Term Symbols, Selection rules, UV-Vis spectroscopy.
Structure Determination & Aromatics
Carbon and proton NMR, mass spectrometry, aromaticity and conjugation, resonance, Huckel's rule, introduction to heterocycles. Chemistry and reactivity of aromatics.
Quantum Phenomena II
Particle in a box, scanning microscopy, vibrational and rotational energy levels.
Synthetic Chemistry II
Electrophilic addition, regio- and stereo-selectivity. Chemistry of enols and enolates, tautomerism, nucleophilic reactivity, alkylation and aldol reaction.
There will be 8 sessions divided equally between: Synthetic chemistry (introduce the student to a variety of techniques to prepare chemicals in a safe manner) and Measurement and Analysis (introduces the student to techniques for studying and quantifying chemical processes).
Formative tutorial sessions will be held weekly and will provide the student with the opportunity to answer and discuss material from the lecture course.
Specialist tutorials will be held fortnightly and will provide students with the opportunity to have in depth discussion on structural characterisation using various scientific techniques.
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment task Type of assessment Percentage of total assessment for grading purposes Hurdle (Yes/No) Outcomes being assessed Assignments Summative 10% No 1 – 9 Extended Practical Report Summative 5% No 10 Practical Reports Formative & Summative 20% Yes (60%) 1 – 10 Presentation Formative & Summative 0-5% No 1 – 9 Exam Summative 55-60% Yes (45%) 1 – 9
Assessment Related Requirements
Practical work is compulsory – This includes conduct of required experimental work, attendance at demonstrator interviews (as required) and submission of the laboratory reports.
To pass this course students must:
- Attain a minimum of 60% for the practical reports:
Students who do not attain this minimum requirement will not be offered an additional assessment.
- Attain a minimum of 45% for the exam:
Students who attain a final course grade of at least 45% but do not attain a minimum of 45% for the exam may be offered an Additional Academic Exam during the Replacement/Additional Assessment period, in line with the Modified Arrangements for Coursework Assessment Policy.
This assessment activity specifically covers lecture course content and is designed to encourage students to engage with the subject matter through semester (4 short-answer assignments). The assignments are supported and enhanced by students’ participation in tutorials.
Extended Practical Report
This assessment activity addresses the scientific communication aspects in the chemical laboratories. Students will write the extended practical report based on the contents in one of the short practical reports.
This assessment activity comprehensively addresses the practical aspects of chemistry and competent training in the techniques employed in chemical laboratories (8 short, hand-written practical reports submitted in class).
An opportunity to make-up a maximum of one missed practical session may be offered during the semester. Students must contact the Course Coordinator as soon as possible if they have missed their practical as practical classes are often full and additional space is often unavailable.
This assessment activity covers the specialist tutorial topics in which students are required to give a 10 minute presentation in pairs (5 minutes per student).Each pair is assigned a topic covered specifically in the specialist tutorials and provided with some background material and a research paper to study in class. Students are required to do a presentation to outline their understanding of the topic and present it to the class. The requirements and marking scheme for the presentation are provided to students at the start of the semester.
The higher aggregate mark out of (0% Specialist Tutorials Presentation + 60% Final exam) and (5% Specialist Tutorials Presentation + 55% Final exam) will be used to calculate the final grade.
This assessment activity comprehensively addresses the learning outcomes.
Submission of Assigned Work
Coversheets must be completed and attached to all submitted work. Coversheets can be obtained from the School Office (room G33 Physics) or from MyUNI. Work should be submitted via the assignment drop box at the School Office.
Extensions for Assessment Tasks
Extensions of deadlines for assessment tasks may be allowed for reasonable causes. Such situations would include compassionate and medical grounds of the severity that would justify the awarding of a supplementary examination. Evidence for the grounds must be provided when an extension is requested. Students are required to apply for an extension to the Course Coordinator before the assessment task is due. Extensions will not be provided on the grounds of poor prioritising of time.
Late submission of assessments
If an extension is not applied for, or not granted then a penalty for late submission will apply. A penalty of 10% of the value of the assignment for each calendar day that is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days or more late without an approved extension can only receive a maximum of 50% of the mark.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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This section contains links to relevant assessment-related policies and guidelines - all university policies.
- Academic Credit Arrangement Policy
- Academic Honesty Policy
- Academic Progress by Coursework Students Policy
- Assessment for Coursework Programs
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- Modified Arrangements for Coursework Assessment
- Student Experience of Learning and Teaching Policy
- Student Grievance Resolution Process
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