BIOCHEM 3230 - Molecular & Structural Biology III (Biomed Sci)
North Terrace Campus - Semester 1 - 2017
General Course Information
Course Code BIOCHEM 3230 Course Molecular & Structural Biology III (Biomed Sci) Coordinating Unit School of Biological Sciences Term Semester 1 Level Undergraduate Location/s North Terrace Campus Units 6 Contact Up to 23 hours per fortnight Available for Study Abroad and Exchange N Prerequisites BIOCHEM 2500 & BIOCHEM 2501 Incompatible BIOCHEM 3000 Restrictions Available to BSc(BiomedSc) students only Course Description This course combines lectures from Molecular and Structural Biology lll (BIOCHEM 3000) with practical exercises and/or laboratory placements in professional research laboratories in the first six weeks of the semester. In the last six weeks of the semester, it includes a special set of Problem Based Learning (PBL)/Tutorial exercises, not offered in any other course, which are designed to provide students with a perspective of how cutting edge biomedical science principles and techniques are applied to major research questions. This course will illustrate that cross disciplinary approaches are essential in modern biomedical science research.
Course Coordinator: Dr John Bruning
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Understanding aspects of protein structure and function including protein folding, degradation, development of new therapies, molecular interactions and recognition. 2 Understanding aspects of the control of gene expression including genetic circuits, chromatin structure and remodelling, gene promoter assembly, eukaryotic mRNA synthesis, processing and translation. 3 Understanding key experimental processes required to evaluate protein structure, function and gene expression, and knowledge of how to apply them to solve specific biochemical problems. 4 Specific skills in planning, performing, interpreting, quantitatively analysing and communicating biochemical research using a variety of modern experimental techniques. 5 Ability to find, read, interpret and critically analyse relevant scientific literature. 6 Ability to work in teams and communicate scientific outcomes.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
1 - 6 Critical thinking and problem solving
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
1 - 6 Teamwork and communication skills
- developed from, with, and via the SGDE
- honed through assessment and practice throughout the program of studies
- encouraged and valued in all aspects of learning
1 - 6 Career and leadership readiness
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
1 - 6 Intercultural and ethical competency
- adept at operating in other cultures
- comfortable with different nationalities and social contexts
- Able to determine and contribute to desirable social outcomes
- demonstrated by study abroad or with an understanding of indigenous knowledges
1 - 6 Self-awareness and emotional intelligence
- a capacity for self-reflection and a willingness to engage in self-appraisal
- open to objective and constructive feedback from supervisors and peers
- able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
1 - 6
Required ResourcesLaboratory coat, safety glasses and closed shoes.
Recommended ResourcesText book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
Online LearningResource material such as lecture, tutorial, practical and past exams will be available on Myuni.
Online assessment will be conducted via Myuni.
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
3 Lectures of 1 hour each per week.
1 Tutorial of 1 hour per week.
1 Practical of 15 hours per fortnight. (Odd weeks = 5 hours & Even weeks = 10 hour duration) Includes 2 oral presentations in weeks 6, 12/13, with immediate feedback provided.
3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediate feedback provided).
1 hour written test in week 7.
The course content will include the following:
· Protein Life Cycle
· Protein-Protein Interactions
· Protein-carbohydrate / small molecule interactions
· Proteins and Drug Design
· Protein-nucleic Acid Interactions
· Genetic Circuits and Synthetic Biology
· Chromatin Remodelling and Transcriptional Control
· How Transcription Factors are Regulated to Control Complex Promoters
The research-based practicals are run by the Biochemistry Academic staff as well as PhD students.
The tutorials are based around the lecture content as well as current relevant research papers
The online tests reinforce the lecture material.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary
Topic Lecture 1 Protein Life Cycle Lecture 2 Introduction to Macromolecular X-ray Crystallography Lecture 3 Applications of Structural Biology/Proteomics Lecture 4 Proteomics/Protein-nucleic Acid Interactions Lecture 5 Genetic Circuits and Synthetic Biology Lecture 6 Genetic Circuits and Synthetic Biology Lecture 7 Chromatin Remodelling and Transcriptional Control Lecture 8 Chromatin Remodelling and Transcriptional Control Lecture 9 How TranscriptionFactors are Regulated to Control Complex Promoters Lecture 10 How TranscriptionFactors are Regulated to Control Complex Promoters Lecture 11 RNA Processing Lecture 12 RNA Processing Lecture
Small Group Discovery ExperienceStudents perform small group discovery in their practical sessions and PBLs in which they work together in small groups of approximately 12.
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment must maintain academic standards.
Assessment tasks Type of Assessment Percentage of total assessment for grading purposes Hurdle Outcome being assessed Approximate Timing of Assessment Practical report summative 15 no 4, 5, 6 Week 12 PBL report summative 15 no 4, 5, 6 Week 12 Online tests summative 5 no 1, 2 Weeks 4, 8, 12 Exam summative 40 no 1, 2, 3 Exam Period Written Test summative/formative 25 no 1,2,4 Week 7
Assessment Related RequirementsAttendance and active participation at all practicals is mandatory
Assessment DetailEnd of term Exam (40% of total course grade) – A 2 hour examination covering the lecture material. It is made up of short and
long answer type questions.
Mid-term written test (25% of total course grade) – A 1 hour examination covering the lecture material. It is made up of short and long answer type questions.
Practical (30% of total course grade). The semester long practical exercise will include experimental work, keeping an up to date laboratory notebook, 2 oral presentations and the submission of a final practical report. The two oral presentations are each 10-15 minutes, cover the research performed in the practical, and performed in small groups in weeks 6, 12/13. Students receive feedback throughout the semester on laboratory performance and keeping of laboratory notebooks immediately after each oral presentation, and on the final report. Outstanding students may have the option of a laboratory-based research project in place of the practical exercise.
Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (5% of total course grade). Encourages revision of the material soon after the relevant lectures and immediate feedback provided to students. This is done outside of contact time.
SubmissionIf an extension is not applied for, or not granted,then a penalty for late submission
will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Final results for this course will be made available through Access Adelaide.
Provision of Feedback to Students
The assessor usually provides appropriate feedback of assessment tasks to the student by means of
written comments. The student has the opportunity to directly liaise with the assessor to obtain additional feedback and clarification if required.
- Academic Support with Maths
- Academic Support with writing and speaking skills
- Student Life Counselling Support - Personal counselling for issues affecting study
- International Student Support
- AUU Student Care - Advocacy, confidential counselling, welfare support and advice
- Students with a Disability - Alternative academic arrangements
- Reasonable Adjustments to Teaching & Assessment for Students with a Disability Policy
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