BIOTECH 7001 - Drug Discovery and Development
North Terrace Campus - Semester 1 - 2014
General Course Information
Course Code BIOTECH 7001 Course Drug Discovery and Development Coordinating Unit School of Molecular and Biomedical Science Term Semester 1 Level Postgraduate Coursework Location/s North Terrace Campus Units 3 Contact Up to 4 hours per week Assumed Knowledge BIOCHEM 2500 or equivalent Restrictions Available to GCBIBIOM, GDBIBIOM, MBIBIOM students only Course Description Societies across the world are looking to combat a greater range of human diseases but at the same time contain spiralling healthcare costs. This, together with global competition and increasing regulatory standards, puts enormous pressure on the pharmaceutical industry to discover and develop a greater number of therapeutic candidates even faster and cheaper than ever before.
This course develops the key themes in the drug discovery and development pipeline and highlights the multi-disciplinary nature of the research and development process. Topics include: Target identification and validation, Hit discovery, Hit-to-lead optimisation, pre-clinical and clinical testing, regulatory and manufacturing considerations.
Course Coordinator: Dr Grant Booker
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning OutcomesA successful student should be able to:
1 Demonstrate an awareness of the current approaches to global drug discovery and their advantages and limitations. 2 Demonstrate an understanding of the steps involved in the drug discovery and design process 3 Demonstrate an awareness of the important contributions the different discipline areas make to the drug discovery and development process. 4 Critically analyse biological pathways for their potential as drug targets for a given disease. 5 Demonstrate the ability to use evidence-based approaches to guide decision making during the drug discovery and development process. 6 Demonstrate an understanding of the importance of strict quality control and regulation in the drug development process, and an awareness of issues associated with the manufacturing of medicines such as good manufacturing practice. 7 Critically analyse and integrate information from the scientific literature. 8 Present to an audience in summary the critical evaluation of the scientific literature and experimental data
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s)
Required ResourcesMolecular Graphics Software
Access to the free molecular grpahics software "Chimera" is required for the drug design workshops
Course resources as provided including video/audio recording of lectures and copies of PowerPoint slides, as well as additional reading/recommended texts
As specified during the course
Scientific literature and journal articles
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
1 or 2 x 1 hour lectures per week
1 x 2 hour workshop/tutorial per week
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.Contact Hours (45 hours)
Lectures 18 x 1 = 18 hours
Workshops 12 x 2 = 24 hours
Exam 1 x 3 hours = 3 hours
Non-contact Hours (110 hours)
Weekly reading/other study hours per lecture = 36 hours
Preparation for workshops 2 hour per week = 24 hours
Preparation for presentations = 6 hours
Major essay = 20 hours
Exam preparation= 24 hours
Total = approximately 155 hours
Learning Activities SummaryThe topics covered in the course and supported by online resources are as follows:
- Lecture 1-2: Introduction to drug discovery and target product profiles
- Lectures 3-4: High throughput screening methods.
- Lectures 5-6 Medicinal chemistry
- Lecture 7-8: Pharmacology and ADME toxicology
- Lecture 9-12: Fragments, peptidomimetics and structure based drug design
- Lecture 13: IP considerations
- Lectures 14-18: Case studies in drug discovery.
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Task Type Due Weighting Learning Outcome Target Product Profile Presentation Formative and Summative End week 8 10% 1-8 Drug Design Workshop Portfolio Formative and Summative End week 12 15% 1-3,5 Written Assignment Formative and Summative End Week 11 25% 4,7 End of Semester theory exam Summative In examination period 50% 1-6
No information currently available.
No information currently available.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
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