BIOCHEM 3520 - Cancer, Stem Cells and Development (Theory) III

North Terrace Campus - Semester 2 - 2019

This course will study the regulation of cellular signalling, proliferation and differentiation in the context of diseases such as cancer, and in normal embryonic development. It will provide detailed information on the major conceptual and technical advances in this field, including specific medical applications, focussing on three principle themes: Cell Signalling: Epigenetics in cell differentiation and memory, lipid anchors, signal regulation, GPCRs, insulin and cannabinoid signalling, adipokines, kinases and cancer therapeutics, and calcium signalling. Molecular Basis of Cancer: Principles and hallmarks of cancer, clonal selection, driver mutations, cell cycle, DNA damage, senescence, genomic instability, tumour suppressors, liquid tumours, mTOR, cancer metabolism, oncometabolites, and drug development for prostate cancer, CML and ALL. Stem Cells and Development: Embryonic development, axis formation, pluripotency, embryonic, adult, and induced pluripotent stem cells, medical applications, gene targeting, CRISPR, in vitro neural differentiation and exploring neural circuits.

  • General Course Information
    Course Details
    Course Code BIOCHEM 3520
    Course Cancer, Stem Cells and Development (Theory) III
    Coordinating Unit School of Biological Sciences
    Term Semester 2
    Level Undergraduate
    Location/s North Terrace Campus
    Units 3
    Contact Up to 4 hours per week
    Available for Study Abroad and Exchange Y
    Prerequisites BIOCHEM 2500 & BIOCHEM 2501
    Corequisites SCIENCE 3100
    Incompatible BIOCHEM 3235 & BIOCHEM 3225
    Restrictions Available to BSc (Advanced) students only
    Course Description This course will study the regulation of cellular signalling, proliferation and differentiation in the context of diseases such as cancer, and in normal embryonic development. It will provide detailed information on the major conceptual and technical advances in this field, including specific medical applications, focussing on three principle themes:
    Cell Signalling: Epigenetics in cell differentiation and memory, lipid anchors, signal regulation, GPCRs, insulin and cannabinoid signalling, adipokines, kinases and cancer therapeutics, and calcium signalling.
    Molecular Basis of Cancer: Principles and hallmarks of cancer, clonal selection, driver mutations, cell cycle, DNA damage, senescence, genomic instability, tumour suppressors, liquid tumours, mTOR, cancer metabolism, oncometabolites, and drug development for prostate cancer, CML and ALL.
    Stem Cells and Development: Embryonic development, axis formation, pluripotency, embryonic, adult, and induced pluripotent stem cells, medical applications, gene targeting, CRISPR, in vitro neural differentiation and exploring neural circuits.
    Course Staff

    Course Coordinator: Associate Professor Dan Peet

    Course Timetable

    The full timetable of all activities for this course can be accessed from Course Planner.

  • Learning Outcomes
    Course Learning Outcomes
    1 Understanding the molecular basis of cancer.
    2 Understanding key aspects of stem cells, cell differentiation and development in lower eukaryotes and vertebrates.
    3 Understanding key experimental processes required to investigate cancer, stem cells and development, and knowledge of how to apply them to solve specific biochemical problems.
    4 Ability to find, read, interpret and critically analyse relevant scientific literature.
    University Graduate Attributes

    This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:

    University Graduate Attribute Course Learning Outcome(s)
    Deep discipline knowledge
    • informed and infused by cutting edge research, scaffolded throughout their program of studies
    • acquired from personal interaction with research active educators, from year 1
    • accredited or validated against national or international standards (for relevant programs)
    1, 2, 3
    Critical thinking and problem solving
    • steeped in research methods and rigor
    • based on empirical evidence and the scientific approach to knowledge development
    • demonstrated through appropriate and relevant assessment
    4
    Teamwork and communication skills
    • developed from, with, and via the SGDE
    • honed through assessment and practice throughout the program of studies
    • encouraged and valued in all aspects of learning
    4
    Career and leadership readiness
    • technology savvy
    • professional and, where relevant, fully accredited
    • forward thinking and well informed
    • tested and validated by work based experiences
    na
    Intercultural and ethical competency
    • adept at operating in other cultures
    • comfortable with different nationalities and social contexts
    • Able to determine and contribute to desirable social outcomes
    • demonstrated by study abroad or with an understanding of indigenous knowledges
    na
    Self-awareness and emotional intelligence
    • a capacity for self-reflection and a willingness to engage in self-appraisal
    • open to objective and constructive feedback from supervisors and peers
    • able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
    na
  • Learning Resources
    Recommended Resources
    Text book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
    Online Learning
    Resource material such as lecture, tutorial and past exams will be available on Myuni. Online assessment will be conducted via Myuni.
  • Learning & Teaching Activities
    Learning & Teaching Modes
    This course will be delivered by the following means:

    3 Lectures of 1 hour each per week. The stacked / same time teaching components are the lectures timetabled with the existing course, Cancer, Stem Cells and Development III (BIOCHEM 3001).

    1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.

    3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediate feedback provided).
    Workload

    The information below is provided as a guide to assist students in engaging appropriately with the course requirements.

    A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
    Learning Activities Summary
    Schedule
    Week 1 Signalling Domains: Structure and Function Lecture
    Week 2 Signalling Domains: Structure and Function/Cell Signalling Pathways Lecture
    Week 3 Cell Signalling Pathways Lecture
    Week 4 Cancer: Cell Cycle/Apoptosis Lecture
    Week 5 Cancer: Cell Cycle/Apoptosis Lecture
    Week 6 Cancer: Adhesion/Migration Lecture
    Week 7 Cancer: Adhesion/Migration Lecture
    Week 8 Cancer and Metabolism Lecture
    Week 9 Axis Determination and Positional Information in Embryos  Lecture
    Week 10 Stem Cells Lecture
    Week 11 Cell Differentiation/Neurogenesis Lecture
    Week 12 Sex Determination Lecture
  • Assessment

    The University's policy on Assessment for Coursework Programs is based on the following four principles:

    1. Assessment must encourage and reinforce learning.
    2. Assessment must enable robust and fair judgements about student performance.
    3. Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
    4. Assessment must maintain academic standards.

    Assessment Summary
    Assessment Task Task Type Due Weighting Learning Outcome
    Written exam on lecture material Summative

    End of semester

     80% 1, 2, 3
    Online assessment Formative and Summative Weeks 4, 8 and 12 20% 1, 2, 3
    Assessment Detail
    End of semester written Exam (80% of total course grade) – 3 hour examination covering the lecture material. It is made up of a mixture of short and long answer type questions.

    Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (20% of total course grade). Encourages revision of the material soon after the relevant lectures, and immediate feedback provided to students.
    Submission
    If an extension is not applied for, or not granted,then a penalty for late submission
    will apply.  A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.
    Course Grading

    Grades for your performance in this course will be awarded in accordance with the following scheme:

    M10 (Coursework Mark Scheme)
    Grade Mark Description
    FNS   Fail No Submission
    F 1-49 Fail
    P 50-64 Pass
    C 65-74 Credit
    D 75-84 Distinction
    HD 85-100 High Distinction
    CN   Continuing
    NFE   No Formal Examination
    RP   Result Pending

    Further details of the grades/results can be obtained from Examinations.

    Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

    Final results for this course will be made available through Access Adelaide.

  • Student Feedback

    The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

    SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

  • Student Support
  • Policies & Guidelines
  • Fraud Awareness

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