PHARM 3103 - Drug Action and Therapeutics
North Terrace Campus - Semester 1 - 2019
General Course Information
Course Code PHARM 3103 Course Drug Action and Therapeutics Coordinating Unit Medicine Term Semester 1 Level Undergraduate Location/s North Terrace Campus Units 3 Contact Up to 3 hours per week Available for Study Abroad and Exchange Y Prerequisites HLTH SC 2104 Incompatible PHARM 3010 Course Description The course will provide students with an understanding of how drugs are used as therapeutics. Students will gain an understanding of drug-receptor interactions. Particular emphasis will be given to the key factors that influence and govern the effects of drugs within the body, ranging from molecular determinants to physiological factors that control disposition of drugs within the body. Selected systems pharmacology examples will be given to illustrate contemporary approaches to treatment of disease. The practical component of this course will demonstrate key issues from the theoretical part of the course as well as providing laboratory and experimental proficiency for students, ensuring they gain an appreciation for studying drug actions at different levels of biological organisation, ranging from simple in vitro systems (e.g. organ baths) to whole animals.
Course Coordinator: Dr Ian MusgraveCourse Coordinator: Dr Ian Musgrave
Phone: +61 8 8313 3905
Location: Room S515, Medical School South
Additional Academic Staff
Dr Scott Smid
Phone: +61 8 8313 5287
Location: Room N531, Medical School North
Dr Abdallah Salem
Phone: +61 8 8313 4327
Room N506, Medical School North
Dr Janet Coller
Phone: +61 8 8313 3906
Location: Room N515, Medical School North
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning OutcomesOn successful completion of this course students will be able to:
1. Recognise the fundamental principles of drug actions at their target sites (eg. receptors, enzymes etc)
2. Describe the different types of pharmacodynamic interactions of drugs with receptors and apply quantitative methods to analyse such interactions
3. Demonstrate knowledge of the actions of specific drug classes at selected organ systems and physiological pathways at a molecular and cellular level
4. Explain the functioning of the autonomic nervous system at a pharmacological, anatomical and physiological level, with an integrated approach to its role in physiological homeostasis
5. Compare the functional roles of selected central nervous system transmitters and be able to list clinically important drugs acting at these pharmacological systems
6. Choose a relevant experimental system to test experimental hypotheses (e.g. in vitro or in vivo; animal species etc)
7. Design experiments which are properly controlled and which use appropriate statistical methods of data analysis
8. Work co-operatively in a small group setting to conduct experiments, generate, analyse and interpret experimental data 9. Consider ethical issues when designing experiments using humans or animals
10. Consider the importance of method validation, and the recognition of experimental errors
University Graduate Attributes
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
3-10 Teamwork and communication skills
- developed from, with, and via the SGDE
- honed through assessment and practice throughout the program of studies
- encouraged and valued in all aspects of learning
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
7.8 Intercultural and ethical competency
- adept at operating in other cultures
- comfortable with different nationalities and social contexts
- Able to determine and contribute to desirable social outcomes
- demonstrated by study abroad or with an understanding of indigenous knowledges
9 Self-awareness and emotional intelligence
- a capacity for self-reflection and a willingness to engage in self-appraisal
- open to objective and constructive feedback from supervisors and peers
Required Resources“Rang and Dale's pharmacology” by Rang, Dale, Ritter, Flower and Henderson (Elsevier, 2015, 8th Edition). This book is an
excellent introduction to all aspects of pharmacology and lecturers will assign relevant chapters for each lecture.
Australian Medicines Handbook (online via BSL)
Recommended ResourcesStudents will be able to open access a variety of third party online and library
resources. Links to journal articles and reading lists disseminated via MyUni.
Online LearningThe primary means of communication outside of the formal contact hours will be via MyUni (or Canvas). Announcements supported
by email will be used as the main method of communicating with the student cohort.
Course material will besupported by online resources, with lecture recordings, tutorial materials and on-line quizzes and tests conducted via MyUni (Canvas).
Lecture notes will be provided in either pdf or PowerPoint format, relevant lab and tutorial handouts
and other supporting materials as required. Material will be sequentially released in line with the teaching and learning activities in each week.
Learning & Teaching Activities
Learning & Teaching ModesThis course is comprised of a combination of didactic lectures, interactive tutorial sessions and prescribed laboratory group-based practical sessions. Problem based tutorials are designed to support the major learning objectives set in the lecture content and require student interaction. Group-based laboratory practicals are designed to reinforce and extend on learning provided in the themed lecture content as well as providing an understanding and proficiency in research methods and experimental design, data analysis and write-up.
WorkloadYou should spend at minimum 16 hours a week on study activities for this course. This will include an average of 8 hours contact time (lecture/practical/tutorial) and 8 hours revision/preparation/study.
Learning Activities SummaryTutorial classes are based on the themed lecture content above and are usually set to follow the completion of lecture delivery within the prescribed theme.
Additional tutorial content is delivered in the areas of drug calculations and dilutions and biostatistics, which are topics that reinforce aspects of teaching in the practical classes.
Session 1- Analytical (quantitative) Methodology
Session 2- Agonist/Antagonist activity in isolated tissues
Session 3- Receptor tolerance
Session 4- Adrenoceptors
Session 5- Receptors & Signal Transduction
Session 6- Drug actions In Vivo CNS
Week Lecture 1 Lecture 2 Tutorial 1
Pharmacodynamics I- Drug Targets: Receptors, Enzymes and
Pharmacodynamics II- Dose-Response and Quantitation of Drug Actions
Pharmacodynamics III- Agonists/Antagonists
Analytical Methodology 3
Transmitter Systems & Drug Action I -
Transmitter Systems & Drug Action II - Adrenergic none 4
Drugs in CNS disease I
Transmitter Systems & Drug Action III
Drugs in CNS disease II
Transmitter Systems & Drug Action IV
DA and GABA modifying drugs
Receptors and Signal transduction I
G-protein coupled receptors
Receptors and Signal transduction II
Receptors and Signal transduction III
Tyrosine Kinases & Nuclear receptors
Receptors and Signal transduction IV
Drugs in the Nervous system 7
Pharmacotherapeutics I- Pharmacology of inflammation
Pharmacology of pain
Affective disorders I
Affective disorders I
Signal Transduction 9
Endocrine & metabolic pharmacology I
Pharmacotherapeutics VI -
Therapeutics I 11
Performance enhancing Drugs
Cardiovascular pharmacology I
Cardiovascular pharmacology II
Exam revision Therapeutics II
Specific Course RequirementsLaboratory Conduct
PROTECTIVE CLOTHING :
(LABORATORY COATS and SAFETY GLASSES) MUST BE WORN IN THE LABORATORY.
Thongs should not be worn, and bare feet are absolutely prohibited (danger from glass and spillage).
Wash your hands before meals or on leaving the laboratory for any reason.All possible precautions should be taken when handling body fluid, to prevent spread of any type of infection.
These are:prevent aerosol production (e.g. never mix the fluids with hot water)use disposable gloves;wash hands after handling biological samples;
Avoid contaminating your hands, face or clothes, or the benches, chairs,
stools, notebooks, floors, door-handles, switches, gas, water, pressure,
vacuum or other taps, with animal excreta, toxins, chemicals or drugs.
Other people have to handle things you may have touched. Don't suck pencils or anything similar in the laboratory.No food or drink should be consumed or brought into the laboratory.No smoking should take place in the laboratory.
All solutions should be treated with care. Any material, dry or in solution, spilt on to the bench, the floor, or the hands should be
cleaned up at once with disposable paper towels. Spills should be cleaned up immediately and hands washed after any inadvertent contact.
No drug or syringe must leave the department for any reason.All sharps (hypodermic needles, scalpel blades) must be placed in the yellow sharps disposal bins placed around the laboratory.Solid waste should be placed in the appropriate bins, not in the sink.
Studentsshould pay particular attention to the care of animals.
aspects of using animals and techniques for handling and injecting
animals will be demonstrated.
Any equipment failure or other faults should be reported to a demonstrator or to a technician.
At the conclusion of the experiment, it is the student’s responsibility to tidy the work space and to ensure that tubes, tips etc are disposed of in the appropriate bins provided.
No unauthorised persons are to visit students while working in the laboratory.
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment must maintain academic standards.
Assessment Task Assessment Type Weighting Learning Outcome(s) being addressed Final Exam Summative 50% 1-4 Assessment Test I Summative 10% 3 Assessment Test II Summative 10% 1-2 Practicals Summative and formative 30% 5
Assessment Related RequirementsNot Applicable
Online quizzes: Students will access 2 online MCQ formatted quizzes
which will be at weeks 6 and 10 to provide students with a reflective formative
appraisal of their understanding of key concepts from lectures. 0%
Test 1: Online MCQ-based test on all lecture and tutorial content weeks 1-6 inclusive, undertaken in week 7. 10%
Test 2: Written short answer-based
test on all practical content, undertaken in week 12. 10% weighting
Practicals: Students work in small groups to investigate key experiments which illustrate and re-enforce theoretical concepts. Written reports produced and assessed. 30% weighting.
Examination: A 2 hour exam to be held at the end of semester. 50% weighting.
SubmissionAll written submissions (eg. practical reports) must
be accompanied by a signed cover sheet. Proforma cover sheets will be
available for download off MyUni.
Late submissions of any student work are not acceptable. Coursework
received after the deadline will be penalised as follows:10% of total
available points will be penalised per day (24 hour period or fraction
thereof). An automatic zero mark will be applied after 7 days
If you miss an assessment test e.g. from illness, you are required to
present medical or compassionate certification to be eligible to sit a
supplementary test. Such certificates need to be provided to The Course
Coordinator directly within one week of the test date.
The date and time of the supp. test is then determined by the Course
Coordinator and is not negotiable. Students will be informed of the
supp. test date by email.
Turn-around times for marking practial reports are 1 week
from date of submission. Marked assessment tests are normally returned
within 1-2 weeks from date of sitting.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Final results for this course will be made available through Access Adelaide.
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