PHARM 3102 - Preclinical Drug Discovery & Development
North Terrace Campus - Semester 2 - 2019
General Course Information
Course Code PHARM 3102 Course Preclinical Drug Discovery & Development Coordinating Unit Medicine Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 3 Contact Up to 4 hours per week Available for Study Abroad and Exchange Y Prerequisites HLTH SC 2104 Incompatible PHARM 3010 or PHARM 3011 Assumed Knowledge PHARM 3103 Course Description This course will provide students with a fundamental knowledge of drug discovery and development with a preclinical focus. This includes both conventional, historical and contemporary approaches to sourcing and developing new drugs, from natural sources through to rational drug design, lead optimisation and both in vitro and in vivo screening approaches for drug efficacy and safety, including pharmacogenomic and pharmacokinetic considerations. Additional topics in commercialisation from industry and academic perspectives provide students with a comprehensive knowledge of how new drugs are sourced, developed and evaluated for effectiveness and safety prior to clinical testing.
Course Coordinator: Dr Scott SmidDr Scott Smid
Dr Ian Musgrave
Professor Sepehr Shakib
Professor Andrew Somogyi
Dr Janet Coller
Associate Professor Betty Sallustio
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning OutcomesCompare and understand common natural sources of drugs and contemporary approaches to drug design and development
Demonstrate an understanding of the timelines and resources required to discover and develop new drugs in a preclinical setting
Demonstrate an understanding of the critical features of each stage of the preclinical drug development process
Utilise in silico approaches to critically evaluate the pharmacophore for ligand-protein binding
Work in small groups to design a novel drug binding to a protein target at a molecular level
Demonstrate an understanding of the environment and drivers of drug discovery and commercialisation of research
University Graduate Attributes
No information currently available.
Required ResourcesNo specific textbook required. Students will access a variety of supplemental and online resources
Recommended ResourcesSupplemental textbooks to be made available within BSL:
Preclinical Development Handbook, Shayne Cox Gad (Editor). ISBN: 978-0-471-21383-3
Textbook of Drug Design and Discovery. CRC Press. ISBN 9781420063226.
Online LearningThe primary means of communication outside of the formal contact hours will be via Canvas. Announcements will be used as the main method of communicating with the student cohort. Course material will be supported by online resources, with lecture recordings, tutorial materials and on-line quizzes via Canvas. Material will be sequentially released in line with the teaching and learning activities in each week.
Learning & Teaching Activities
Learning & Teaching ModesLectures will be supported by problem-solving tutorials to reinforce and further expand or develop material covered in lectures. Case study or modelling projects are undertaken in workshops and are in small group format supported by nominated project supervisors.
No information currently available.
Learning Activities SummaryOverview to drug discovery and preclinical development: small molecule and biologics
Conventional and historical approaches to drug discovery
Basic and applied pharmacokinetic concepts in drug development
Biotransformation: implications for drug development
Pharmacogenomic considerations in drug development
Drug discovery: Identifying drug targets
Sources for drug discovery: Bioprospecting
Medicinal chemistry concepts in drug development
Preclinical drug screening; In vitro models
Preclinical drug screening: In vivo models
Assessment of toxicology in preclinical drug development:
Commercialisation approaches: academic and industry perspectives
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Online quizzes, tutorial and workshop participation, summative tests, molecular modelling and development project and final exam
Online quizzes: Students will access 2 online MCQ formatted quizzes which will be at weeks 6 and 10 to provide students with a reflective formative appraisal of their understanding of key concepts from lectures. 0%
Test 1: Online MCQ-based test on all lecture and tutorial content weeks 1-6 inclusive, undertaken in week 7. 10% weighting
Test 2: Written MCQ and short answer-based test on all lecture and tutorial content weeks 7-11 inclusive, undertaken in week 12. 10% weighting
Project: Students work in small groups to investigate the development of small molecule based approach for an assigned protein target using molecular modelling. Students provide a written report on completion and group presentation. 30% weighting.
Examination. A 2 hour exam to be held at the end of semester. 50% weighting.
No information currently available.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
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