PHARM 3102 - Preclinical Drug Discovery & Development

North Terrace Campus - Semester 2 - 2018

This course will provide students with a fundamental knowledge of drug discovery and development with a preclinical focus. This includes both conventional, historical and contemporary approaches to sourcing and developing new drugs, from natural sources through to rational drug design, lead optimisation and both in vitro and in vivo screening approaches for drug efficacy and safety, including pharmacogenomic and pharmacokinetic considerations. Additional topics in commercialisation from industry and academic perspectives provide students with a comprehensive knowledge of how new drugs are sourced, developed and evaluated for effectiveness and safety prior to clinical testing.

  • General Course Information
    Course Details
    Course Code PHARM 3102
    Course Preclinical Drug Discovery & Development
    Coordinating Unit Medicine
    Term Semester 2
    Level Undergraduate
    Location/s North Terrace Campus
    Units 3
    Contact Up to 4 hours per week
    Available for Study Abroad and Exchange Y
    Prerequisites HLTH SC 2104
    Incompatible PHARM 3010 or PHARM 3011
    Assumed Knowledge PHARM 3103
    Course Description This course will provide students with a fundamental knowledge of drug discovery and development with a preclinical focus. This includes both conventional, historical and contemporary approaches to sourcing and developing new drugs, from natural sources through to rational drug design, lead optimisation and both in vitro and in vivo screening approaches for drug efficacy and safety, including pharmacogenomic and pharmacokinetic considerations. Additional topics in commercialisation from industry and academic perspectives provide students with a comprehensive knowledge of how new drugs are sourced, developed and evaluated for effectiveness and safety prior to clinical testing.
    Course Staff

    Course Coordinator: Dr Scott Smid

    Dr Scott Smid
    Dr Ian Musgrave
    Professor Sepehr Shakib
    Professor Andrew Somogyi
    Dr Janet Coller
    Associate Professor Betty Sallustio
    Course Timetable

    The full timetable of all activities for this course can be accessed from Course Planner.

  • Learning Outcomes
    Course Learning Outcomes
    Compare and understand common natural sources of drugs and contemporary approaches to drug design and development
    Demonstrate an understanding of the timelines and resources required to discover and develop new drugs in a preclinical setting
    Demonstrate an understanding of the critical features of each stage of the preclinical drug development process
    Utilise in silico approaches to critically evaluate the pharmacophore for ligand-protein binding
    Work in small groups to design a novel drug binding to a protein target at a molecular level
    Demonstrate an understanding of the environment and drivers of drug discovery and commercialisation of research
    University Graduate Attributes

    No information currently available.

  • Learning Resources
    Required Resources
    No specific textbook required. Students will access a variety of supplemental and online resources
    Recommended Resources
    Supplemental textbooks to be made available within BSL:

    Preclinical Development Handbook, Shayne Cox Gad (Editor). ISBN: 978-0-471-21383-3
    Textbook of Drug Design and Discovery. CRC Press. ISBN 9781420063226.
    Online Learning
    The primary means of communication outside of the formal contact hours will be via Canvas. Announcements will be used as the main method of communicating with the student cohort. Course material will be supported by online resources, with lecture recordings, tutorial materials and on-line quizzes via Canvas. Material will be sequentially released in line with the teaching and learning activities in each week.
  • Learning & Teaching Activities
    Learning & Teaching Modes
    Lectures will be supported by problem-solving tutorials to reinforce and further expand or develop material covered in lectures. Case study or modelling projects are undertaken in workshops and are in small group format supported by nominated project supervisors.
    Workload

    No information currently available.

    Learning Activities Summary
    Overview to drug discovery and preclinical development: small molecule and biologics
    Conventional and historical approaches to drug discovery
    Basic and applied pharmacokinetic concepts in drug development
    Biotransformation: implications for drug development
    Pharmacogenomic considerations in drug development
    Drug discovery: Identifying drug targets
    Sources for drug discovery: Bioprospecting
    Medicinal chemistry concepts in drug development
    Preclinical drug screening; In vitro models
    Preclinical drug screening: In vivo models
    Assessment of toxicology in preclinical drug development:
    Commercialisation approaches: academic and industry perspectives
  • Assessment

    The University's policy on Assessment for Coursework Programs is based on the following four principles:

    1. Assessment must encourage and reinforce learning.
    2. Assessment must enable robust and fair judgements about student performance.
    3. Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
    4. Assessment must maintain academic standards.

    Assessment Summary

    Online quizzes, tutorial and workshop participation, summative tests, molecular modelling and development project and final exam
    Assessment Detail

    Online quizzes: Students will access 2 online MCQ formatted quizzes which will be at weeks 6 and 10 to provide students with a reflective formative appraisal of their understanding of key concepts from lectures. 0%

    Test 1: Online MCQ-based test on all lecture and tutorial content weeks 1-6 inclusive, undertaken in week 7. 10% weighting

    Test 2: Written MCQ and short answer-based test on all lecture and tutorial content weeks 7-11 inclusive, undertaken in week 12. 10% weighting

    Project: Students work in small groups to investigate the development of small molecule based approach for an assigned protein target using molecular modelling. Students provide a written report on completion and group presentation. 30% weighting.

    Examination. A 2 hour exam to be held at the end of semester. 50% weighting.
    Submission

    No information currently available.

    Course Grading

    Grades for your performance in this course will be awarded in accordance with the following scheme:

    M10 (Coursework Mark Scheme)
    Grade Mark Description
    FNS   Fail No Submission
    F 1-49 Fail
    P 50-64 Pass
    C 65-74 Credit
    D 75-84 Distinction
    HD 85-100 High Distinction
    CN   Continuing
    NFE   No Formal Examination
    RP   Result Pending

    Further details of the grades/results can be obtained from Examinations.

    Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

    Final results for this course will be made available through Access Adelaide.

  • Student Feedback

    The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

    SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

  • Student Support
  • Policies & Guidelines
  • Fraud Awareness

    Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student’s disciplinary procedures.

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