BIOCHEM 3004 - Molecular and Structural Biology (Theory) III
North Terrace Campus - Semester 1 - 2022
General Course Information
Course Code BIOCHEM 3004 Course Molecular and Structural Biology (Theory) III Coordinating Unit School of Biological Sciences Term Semester 1 Level Undergraduate Location/s North Terrace Campus Units 3 Contact up to 4 hours per week Available for Study Abroad and Exchange Y Prerequisites BIOCHEM 2500 & BIOCHEM 2501 or BIOCHEM 2502 & BIOCHEM 2503 Incompatible BIOCHEM 3230, BIOCHEM 3000 and BIOCHEM 3125 Course Description This course aims to extend the discussions of protein structure and function presented in the Biochemistry Level II courses and to use this knowledge to gain an understanding of some of the essential processes of molecular biology. The course covers two principle themes: Protein Structure and Function: topics include - structure and function of different classes of proteins, protein folding, targeted protein degradation, the development of new therapies, molecular interactions and recognition. The Control of Gene Expression: topics include ? genetic circuits and synthetic biology; chromatin structure and its remodelling during transcription; the recruitment and assembly of transcription factors and the RNA polymerase complex on a gene promoter; artificially manipulating gene expression with the use of ?designer genes? and synthetic transcription factors; eukaryote mRNA synthesis, processing, modification, stability and translation, and manipulation of these processes to effect selective gene expression. This course combines lectures and tutorials with cutting edge research-based problem solving to complement the lecture material.
Course Coordinator: Dr John BruningTara Pukala
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Understand aspects of protein structure and function including protein folding, degradation, development of new therapies, molecular interactions and recognition. 2 Understand aspects of the control of gene expression including genetic circuits, chromatin structure and remodelling, gene promoter assembly, eukaryotic mRNA synthesis, processing and translation. 3 Understand key experimental processes required to evaluate protein structure, function and gene expression, and knowledge of how to apply them to solve specific biochemical problems. 4 Find, read, interpret and critically analyse relevant scientific literature.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s)
Attribute 1: Deep discipline knowledge and intellectual breadth
Graduates have comprehensive knowledge and understanding of their subject area, the ability to engage with different traditions of thought, and the ability to apply their knowledge in practice including in multi-disciplinary or multi-professional contexts.
Attribute 2: Creative and critical thinking, and problem solving
Graduates are effective problems-solvers, able to apply critical, creative and evidence-based thinking to conceive innovative responses to future challenges.
Attribute 3: Teamwork and communication skills
Graduates convey ideas and information effectively to a range of audiences for a variety of purposes and contribute in a positive and collaborative manner to achieving common goals.
Attribute 4: Professionalism and leadership readiness
Graduates engage in professional behaviour and have the potential to be entrepreneurial and take leadership roles in their chosen occupations or careers and communities.
Attribute 5: Intercultural and ethical competency
Graduates are responsible and effective global citizens whose personal values and practices are consistent with their roles as responsible members of society.
Attribute 8: Self-awareness and emotional intelligence
Graduates are self-aware and reflective; they are flexible and resilient and have the capacity to accept and give constructive feedback; they act with integrity and take responsibility for their actions.
Required ResourcesText book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
Online LearningResource material such as lecture, tutorial and past exams will be available on Myuni. Online assessment will be conducted via Myuni.
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
3 Lectures of 1 hour each per week. The stacked / same time teaching components are the lectures timetabled with the existing course, BIOCHEM 3000.
1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.
3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediate feedback provided).
Lectures will all be delivered in person and online, with a combination of prerecorded and live-streamed (Zoom) lectures.It is anticipated that tutorials will be a combination of face-to-face and live-streamed (Zoom) tutorials, with one each week recorded.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.The information below is provided as a guide to assist students in engaging appropriately with the course requirements.
A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary1. Introduction to macromolecular X-ray crystallography
2. Applications of structural biology
3. Protein life cycle
5. Protein-nucleic acid interactions
6. Genetic circuits and synthetic biology
7. Membrane Trafficing
8. Chromatin remodelling and transcriptional control
9. How transcription factors are regulated to control complex promoters
10. How transcription factors are regulated to control complex promoters
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment task Task Type Due Weighting Learning Oucome Written test on lecture material Summative Week 6 30 1-4 Online assessment Formative and Summative Weeks 6, 10 and 12 10 1-4 Written exam on lecture material Summative Examination period 60 1-4
Assessment DetailEnd of term Exam (60% of total course grade) – A 2 hour examination covering the lecture material. It is made up of short and
long answer type questions.
Mid-term written test (30% of total course grade) – A 1 hour examination covering the lecture material. It is made up of short and long answer type questions.
Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (10% of total course grade). Encourages revision of the material soon after the relevant lectures and immediate feedback provided to students. This is done outside of contact time.
SubmissionIf an extension is not applied for, or not granted,then a penalty for late submission
will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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- Reasonable Adjustments to Teaching & Assessment for Students with a Disability Policy
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This section contains links to relevant assessment-related policies and guidelines - all university policies.
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- Academic Progress by Coursework Students Policy
- Assessment for Coursework Programs
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- Modified Arrangements for Coursework Assessment
- Student Experience of Learning and Teaching Policy
- Student Grievance Resolution Process
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