GENETICS 3113 - Genes, Genomes and Molecular Evolution (Theory) III
North Terrace Campus - Semester 1 - 2021
General Course Information
Course Code GENETICS 3113 Course Genes, Genomes and Molecular Evolution (Theory) III Coordinating Unit School of Biological Sciences Term Semester 1 Level Undergraduate Location/s North Terrace Campus Units 3 Contact up to 3 hours per week Available for Study Abroad and Exchange Y Prerequisites GENETICS 2510, GENETICS 2520 Incompatible GENETICS 3110, GENETICS 3111 Course Description The DNA molecules that comprise the informational basis of inheritance in living organisms are collectively referred to as the genome. In this course the organisation, origin and mechanisms of change of prokaryotic and eukaryotic genomes are explored using cytogenetic and molecular genetic analyses. Topics include - structure and function of genomes and chromosomes; chromosomes in disease; the roles of natural selection and chance as drivers of molecular evolution.
Course Coordinator: Professor Frank Grutzner
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes1. Knowledge at an advanced level of the origin, structure, function and evolution of genomes and chromosomes; and the roles of chance, mutation and natural selection in evolution at the molecular genetic level.
2. The ability to interpret the primary scientific literature in cytogenetics and evolutionary genetics.
3. Application and integration of knowledge in tutorial exercises
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
1, 2, 3 Critical thinking and problem solving
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
1, 2, 3 Career and leadership readiness
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
1, 2, 3
Required ResourcesProvided by lecturers
Recommended ResourcesProvided by lecturers
Learning & Teaching Activities
Learning & Teaching ModesLectures and workshops
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.Contact sessions
Lectures 24 x 1 hr
Workshops 12 x 2 hrs
Quizzes 2 x 2 hrs
Final Exam 1 x 2 hrs
Reading 12 x 4 hrs
Preperation for tutorials 12 x 4 hrs
Preperation for quizzes 6 x 2 hrs
Preperation for final exam 6 x 2 hrs
Learning Activities SummaryLectures
Chromosome Structure and Evolution
1. Overview – Chromosome Analysis
2. Centromeres and Telomeres
3. Metaphase and Interphase
5. Histone Code
6. Chromosome Evolution
7. Sex Chromosomes in Monotremes I
8. Sex Chromosomes in Monotremes II
1. Genetic Distance
2. Inferring Trees - UPGMa
3. Inferring Trees – Neighbour-Joining
1. A First Look
2. The Decay of Heterozygosity
3. Mutation & Drift
1. The Rate of Substitution & the Neutral Theory
2. Natural Selection & Genetic Drift
3. Natural Selection & Molecular Evolution
1. Linkage Disequilibrium
2. Two-Locus Selection - Genetic Hitchhiking
3. Two-Locus Selection - Clonal Interference
The Evolution of Sex and Sexes
1. The Evolution of Sex I - Hill Robertson Interference
2. The Evolution of Sex II - The Red Queen Hypothesis
3. The Evolution of Sexes
Senescence, Kin Selection & Genomic Imprinting
1. The Evolution of Senescence
2. Kin Selection
3. Genomic Imprinting
Specific Course RequirementsNone
Small Group Discovery ExperienceNone
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment SummaryQuiz 1 Summative 25%
Quiz 2 Summative 25%
Theory Exam Summative 50%
Assessment Related RequirementsNone
Assessment DetailQuizzes (total of 50%)
Students will complete a total of 2 online quizzes during semester (worth 25% each). Quizzes will consist of multiple choice, true/false, numerical and short answer questions.
Theory Exam (50%)
The final 2-hour theory exam will examine the components in the second half of the semester. It will consist of multiple choice, numerical, short answer and long answer questions.
SubmissionQuizes will be administrered online
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
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