BIOPRENG 7066 - Advanced Technologies in Biopharmaceutical Processing

North Terrace Campus - Semester 1 - 2024

Biopharmaceutical engineering is one the most promising areas of development from both the scientific and technology viewpoints. This is because this discipline develops at the intersection of physics, chemistry, biology and engineering. It is expected that biopharmaceutical products play a major role in facilitating therapeutic strategies for the treatment of some of the most important diseases and conditions of the 21st century such as Alzheimer's, Parkinson's and various types of cancer. Moreover, thanks to developments in this area, novel diagnostic and medical devices are available to the general public. Some of the emerging research areas within this field include the discovery and production of novel pharmacological molecules, more effective gene therapies, pharmacogenomics and personalized medicine. This course explores the routes for the implementation of some of these developments going from the lab to the full clinical translation. The general objective of this course is therefore to provide a conceptual and fundamental framework to comprehensively understand each component of a biopharmaceutical development such that students can consider new value propositions to address the upcoming healthcare and industry challenges.

  • General Course Information
    Course Details
    Course Code BIOPRENG 7066
    Course Advanced Technologies in Biopharmaceutical Processing
    Coordinating Unit Bioprocess Engineering
    Term Semester 1
    Level Postgraduate Coursework
    Location/s North Terrace Campus
    Units 3
    Available for Study Abroad and Exchange
    Course Staff

    Course Coordinator: Professor Robert Falconer

    Course Timetable

    The full timetable of all activities for this course can be accessed from Course Planner.

    Tutorial Thursday 11:00am-1:00pm
  • Learning Outcomes
    Course Learning Outcomes
    1. Understand the overview of biopharmaceutical processing
    2. Understand and critical analysis the current advanced technologies applied in manufacturing of CAR T Cell Therapy
    3. Understand the manufacturing Strategies for mRNA Vaccines and Therapeutics
    4. Understand the virus like particles protein platform technologies (Bingyang Zhang)
    5. Understand the advanced biomaterials and technologies applied in DNA/RNA delivery
    6. Demonstrate capability of bioprocess design and technologies selection for monoclonal antibodies manufacturing (Yiran Qu)
    7. Construct a comprehensive advanced technology design for one biopharmaceutical products
    University Graduate Attributes

    This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:

    University Graduate Attribute Course Learning Outcome(s)

    Attribute 1: Deep discipline knowledge and intellectual breadth

    Graduates have comprehensive knowledge and understanding of their subject area, the ability to engage with different traditions of thought, and the ability to apply their knowledge in practice including in multi-disciplinary or multi-professional contexts.

    7

    Attribute 2: Creative and critical thinking, and problem solving

    Graduates are effective problems-solvers, able to apply critical, creative and evidence-based thinking to conceive innovative responses to future challenges.

    2,3,4,5

    Attribute 3: Teamwork and communication skills

    Graduates convey ideas and information effectively to a range of audiences for a variety of purposes and contribute in a positive and collaborative manner to achieving common goals.

    7

    Attribute 4: Professionalism and leadership readiness

    Graduates engage in professional behaviour and have the potential to be entrepreneurial and take leadership roles in their chosen occupations or careers and communities.

    4,5,6,7

    Attribute 5: Intercultural and ethical competency

    Graduates are responsible and effective global citizens whose personal values and practices are consistent with their roles as responsible members of society.

    1,2,7

    Attribute 7: Digital capabilities

    Graduates are well prepared for living, learning and working in a digital society.

    4,5,7

    Attribute 8: Self-awareness and emotional intelligence

    Graduates are self-aware and reflective; they are flexible and resilient and have the capacity to accept and give constructive feedback; they act with integrity and take responsibility for their actions.

    1,6
  • Learning Resources
    Recommended Resources
    1. Niazi, Sarfaraz, Biopharmaceutical manufacturing, Bristol England (Temple Circus, Temple Way, Bristol BS1 6HG, UK): IOP Publishing, 2022 (eBook available from University Library)
    2. Pauline M. Doran, Bioprocess Engineering Principles (2nd Edition, 2003)
    3. Michael Levin, Pharmaceutical Process Scale-up, CRC Press, 2006
    Online Learning
    1. Myuni
    2. University Library to search the journal articles.
  • Learning & Teaching Activities
    Learning & Teaching Modes
    1. On-line study 
    2. face-to-face Workshop 
    3. face-to-face tutorial
    4. Group Presentation
    Workload

    The information below is provided as a guide to assist students in engaging appropriately with the course requirements.


    Activity Contact hours Workload
    Lectures 6 36
    Face-to face workshop 12 36
    Face-to-face tutorial 12 36
    Group Presentation  2 10
    SubTotal                                                                          32                                                   118
    Total                            150 hours                                                        

    Learning Activities Summary
    1. Introduction of biopharmaceutical processing (1 Week)
    2. Advanced technologies applied in manufacturing of CAR T Cell Therapy (2 Weeks)
    3. Manufacturing Strategies for mRNA Vaccines and Therapeutics (2 Weeks)
    4. Virus like particles protein platform technologies (2 weeks)
    5. Advanced biomaterials and technologies applied in DNA/RNA delivery (2 weeks)
    6. Bioprocess design and technologies selection for monoclonal antibodies manufacturing (2 weeks)
    7. Project presentation- advanced technology design for one biopharmaceutical products (1 week)
  • Assessment

    The University's policy on Assessment for Coursework Programs is based on the following four principles:

    1. Assessment must encourage and reinforce learning.
    2. Assessment must enable robust and fair judgements about student performance.
    3. Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
    4. Assessment must maintain academic standards.

    Assessment Summary


    1. 5x assignments: weighting 80% Individual Formative/summative 
    2. Project Oral Presentation: weighting 10% Group Summative 
    3. Project Report: weighting 10% Group Summative 

    The specific due date for each assessment will be available on Myuni

    Assessment Detail

    No information currently available.

    Submission
    On-line submission and hard copy
    Course Grading

    Grades for your performance in this course will be awarded in accordance with the following scheme:

    M10 (Coursework Mark Scheme)
    Grade Mark Description
    FNS   Fail No Submission
    F 1-49 Fail
    P 50-64 Pass
    C 65-74 Credit
    D 75-84 Distinction
    HD 85-100 High Distinction
    CN   Continuing
    NFE   No Formal Examination
    RP   Result Pending

    Further details of the grades/results can be obtained from Examinations.

    Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.

    Final results for this course will be made available through Access Adelaide.

  • Student Feedback

    The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.

    SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.

  • Student Support
  • Policies & Guidelines
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    Students are reminded that in order to maintain the academic integrity of all programs and courses, the university has a zero-tolerance approach to students offering money or significant value goods or services to any staff member who is involved in their teaching or assessment. Students offering lecturers or tutors or professional staff anything more than a small token of appreciation is totally unacceptable, in any circumstances. Staff members are obliged to report all such incidents to their supervisor/manager, who will refer them for action under the university's student’s disciplinary procedures.

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