Dr Tod Fullston

 Position NHMRC Research Fellow
 Org Unit Women's and Children's Health
 Email tod.fullston@adelaide.edu.au
 Telephone +61 8 8313 8188
 Location Floor/Room WS5050.17 ,  Adelaide Health and Medical Sciences ,   North Terrace
  • Qualifications

    Bachelor of Science (BSc)    -  1998

    Bachelor of Science (Hons)  -  1999

    Doctor of Philosophy (PhD)  -  2012

  • Research Funding

    Bill & Melinda Gates Foundation: Phase I Explorations Grant  (Co-Investigator)  -  Awarded 2011

    NHMRC Early Career Fellowship (Peter Doherty - Australian Biomedical Fellowship)  -  Awarded 2012

    Diabetes Research Trust Grant (Co-Invesitgator)  -  Awarded 2013

    Robinson Research Insitute Innovation Seed Funding (Chief Investigator)  -  Awarded 2014

    Robinson Research Insitute Innovation Seed Funding (Co-Investigator)  -  Awarded 2014

    Robinson Research Insitute Innovation Seed Funding (Co-Investigator)  -  Awarded 2015

    NHMRC Project Grant (Co-Investigator)  -  Awarded 2015

    Robinson Research Insitute's Career Development Fellowship  -  Awarded 2016

    The University of Adelaide Early Career Research Fellow  -  Awarded 2017

  • Publications

    33. McPherson NO, Lane M, Sandeman L, Owens JA, Fullston T.  'An Exercise-Only Intervention in Obese Fathers  Restores Glucose and Insulin Regulation in  Conjunction with the Rescue of Pancreatic Islet Cell  Morphology and MicroRNA Expression in Male Offspring.  Nutrients.  2017 Feb 9;9(2). pii: E122
    32. Fullston T, Ohlsson-Teague EM, Print CG, Sandeman LY, Lane M.  'Sperm microRNA Content Is Altered in a Mouse Model of Male Obesity, but the Same Suite of microRNAs Are Not Altered in Offspring's Sperm.  PLoS One. 2016 Nov 4;11(11):e0166076
    31. Akison LK, Andraweera PH, Bertoldo MJ, Brown HM, Cuffe JS, Fullston T, Holland O, and Schjenken JE.  'The Current State of Reproductive Biology Research in Australia and New Zealand: Core Themes from the Society for Reproductive Biology Annual Meeting, 2016.'  Reprod Fertil Dev.  2016 Dec 6. [Epub ahead of print]   Review.
    30. Dickinson H, Moss T, Gatford K, Moritz K, Akison L, Fullston T, Hryciw DH, Maloney C, Morris M, Wooldridge A, Schjenken JE, Robertson SA, Waddell B, Mark P, Wyrwoll C, Thornburg K, Muhlhausler B, Morrison J, For the DOHaDANZ Animals models of DOHaD Research Working group.  'A review of fundamental principles for animal models of DOHaD research: an Australian perspective.'  J Dev Orig Health Dis. 2016 Oct;7(5):449-472.  Review.
    29. McPherson NO, Fullston T, Kang WX, Sandeman LY, Corbett MA, Owens JA, Lane M.  'Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers.'  Sci Rep. 2016 Jun 3;6:27010.
    28. Fullston T, Shehadeh H, Schjenken J, McPherson NO, Robertson SA, Zander-Fox D,  Lane M.  'Obesity: Intergenerational Programming and Consequences. Chapter 6. Paternal Obesity and Programming of Offspring Health.' 2016 IN PRESS - Springer Publishing Company, New York, NY, USA. Editors LR Green & RL Hester.  Book chapter.
    27. Schjenken JE, Zhang B, Chan HY, Sharkey DJ, Fullston T, Robertson SA.  'miRNA Regulation of Immune Tolerance in Early Pregnancy.' Am J Reprod Immunol. 2016 Mar;75(3):272-80.  Review.
    26. McPherson NO, Bell VG, Zander-Fox DL, Fullston T, Wu LL, Robker RL, Lane M.  'When two obese parents are worse than one! Impacts on embryo and fetal development.' Am J Physiol Endocrinol Metab. 2015 Sep 15;309(6):E568-81.
    25. Fullston T, Wu LL, Teede HJ, Moran LJ.  'Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health. Chapter 11: Obesity and Reproductive Dysfunction in Men and Women.'  1st Edition: p119-132.  2015 May. Elsevier Chapters,  Academic Press, Waltham, MA, USA. Editor Watson R. ISBN 9780128008720.  Book Chapter.
    24. Fullston T, Shehadeh H, Sandeman LY, Kang WX, Wu LL, Robker RL, McPherson NO, Lane M.  'Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells.' J Assist Reprod Genet. 2015 May;32(5):725-35.

    23. Fullston T, McPherson NO, Owens JA, Kang WX, Sandeman LY, Lane M.  'Paternal obesity induces metabolic and sperm disturbances in male offspring that are exacerbated by their exposure to an "obesogenic" diet.' Physiol Rep. 2015 Mar;3(3). pii: e12336.

    22. Zander-Fox DL, Fullston T, McPherson NO, Sandeman L, Kang WX, Good SB, Spillane M, Lane M.  'Reduction of Mitochondrial Function by FCCP During Mouse Cleavage Stage Embryo Culture Reduces Birth Weight and Impairs the Metabolic Health of Offspring.' Biol Reprod. 2015 May;92(5):124.

    21. McPherson NO, Owens JA, Fullston T, Lane M.  'Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring.' Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E805-21.

    20. McPherson NO, Fullston T, Aitken RJ, Lane M.  'Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring.' Ann Nutr Metab. 2014; 64(3-4):231-8. Review.

    19.  Lane M, McPherson NO, Fullston T, Spillane M, Sandeman L, Kang WX, Zander-Fox DL. 'Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring.' PLoS One. 2014 Jul 9;9(7): e100832.

    18.  McPherson NO, Fullston T, Bakos HW, Setchell BP, Lane M. 'Obese father's metabolic state, adiposity, and reproductive capacity indicate son's reproductive health.' Fertil Steril. 2014 Mar;101(3):865-873.

    17.  Fullston T, Ohlsson Teague EM, Palmer NO, Deblasio MJ, Mitchell M, Corbett M, Print CG, Owens JA, Lane M.  ‘Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content.’  FASEB J. 2013 Oct;27(10):4226-4243

    16.  Fullston T, Palmer NO, Owens JA, Mitchell M, Bakos HW, Lane M.  'Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice.'  Hum Reprod. 2012 May;27(5):1391-400

    15.  Palmer NO, Bakos HW, Fullston T and Lane M.  'Impact of male obesity on male fertility, sperm function and molecular composition.'  Spermatogenesis.  2012 Oct 1;2(4):253-263. Review.

    14.  Palmer NO, Fullston T, Mitchell M, Setchell BP, Lane M.  'SIRT6 in mouse spermatogenesis is modulated by diet induced obesity.'  Reprod Fertil Dev. 2011 Sep;23(7):929-939

    13.  Fullston T, Mitchell M, Wakefield S, Lane M.  'Mitochondrial inhibition during preimplantation emvryogenesis shifts the transcriptional profile of fetal mouse brain.'  Reprod Fertil Dev. 2011 Jun;23(5):691-701.

    12.  Fullston T, Finnis M, Hackett A, Hodgson B, Brueton L, Baynam G, Norman A, Reish O, Shoubridge C, Gecz J.  'Screening and cell-based assessment of mutations in the Aristaless-related homeobox ARX gene.'  Clin Genet. 2011 Dec;80(6):510-522.

    11.  Fullston T, Gabb B, Callen D, Ullmann R, Woollatt E, Bain S, Ropers HH, Cooper M, Chandler D, Carter K, Jablensky A, Kalaydjieva L, Gecz J.  'Inherited balanced translocation t(9;17)(q33.2;q25.3) concomitant with a 16p13.1 duplication in a patient with schizophrenia.'  Am J Med Genet B Neuropsychiatr Genet. 2011 Mar;156(2):204-214.

    10.  Whibley AC, Plagnol V, Tarpey PS, Abidi F, Fullston T, Choma MK, Boucher CA, Shepherd L, Willatt L, Parkin G, Smith R, Futreal PA, Shaw M, Boyle J, Licata A, Skinner C, Stevenson RE, Turner G, Field M, Hackett A, Schwartz CE, Gecz J, Stratton MR, Raymond FL.  'Fine-scale survey of X chromosome copy number variants and indels underlying intellectual disability.'  Am J Hum Genet. 2010 Aug 13;87(2):173-188.

    9.  Shoubridge C, Fullston T, Gécz J.  'ARX spectrum disorders: making inroads into the molecular pathology.'  Hum Mutat. 2010 Aug;31(8):889-900. Review.

    8.  White R, Ho G, Schmidt S, Scheffer IE, Fischer A, Yendle SC, Bienvenu T, Nectoux J, Ellaway CJ, Darmanian A, Tong X, Cloosterman D, Bennetts B, Kalra V, Fullston T, Gecz J, Cox TC, Christodoulou J.  'Cyclin-dependent kinase-like 5 (CDKL5) mutation screening in Rett syndrome and related disorders.'  Twin Res Hum Genet. 2010 Apr;13(2):168-178.

    7.  Shoubridge C, Tan MH, Fullston T, Cloosterman D, Coman D, McGillivray G, Mancini GM, Kleefstra T, Gécz J.  'Mutations in the nuclear localization sequence of the Aristaless related homeobox; sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division.'  Pathogenetics. 2010 Jan 5;3:1.

    6.  Fullston T, Brueton L, Willis T, Philip S, MacPherson L, Finnis M, Gecz J, Morton J.  'Ohtahara syndrome in a family with an ARX protein truncation mutation (c.81C>G/p.Y27X).'  Eur J Hum Genet. 2010 Feb;18(2):157-162.

    5.  Fullston T, Reish O, Regev M, Heyman E, Gecz J.  'A novel de novo 27 bp duplication of the ARX gene, resulting from postzygotic mosaicism and leading to three severely affected males in two generations.'  Am J Med Genet A. 2009 Aug;149A(8):1655-1660.

    4.  Fullston T, Demos MK, Partington MW, Gécz J, Gibson WT.  'Clinical study of two brothers with a novel 33 bp duplication in the ARX gene.'  Am J Med Genet A. 2009 Jul;149A(7):1482-1486.

    3.  Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, et al, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR.  'A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.'  Nat Genet. 2009 May;41(5):535-543.

    2.  de Brouwer AP, Yntema HG, Kleefstra T, Lugtenberg D, Oudakker AR, et al, Fullston T, Gecz J, Kuss AW, Tzschach A, Jensen LR, Lenzner S, Kalscheuer VM, Ropers HH, Hamel BC.  'Mutation frequencies of X-linked mental retardation genes in families from the EuroMRX consortium.'  Hum Mutat. 2007 Feb;28(2):207-208.

    1.  Santos-Rebouças CB, Abdalla CB, Fullston T, Campos M Jr, Pimentel MM, Gécz J.  'Lack of FMR3 expression in a male with non-syndromic mental retardation and a microdeletion immediately distal to FRAXE CCG repeat.'  Neurosci Lett. 2006 Apr 24;397(3):245-248.

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Entry last updated: Friday, 30 Apr 2021

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