Associate Professor Christopher McDevitt

Associate Professor Christopher McDevitt
 Position ARC Future Fellow
 Org Unit Molecular and Cellular Biology
 Telephone +61 8 8313 0413
 Location Floor/Room 4 13 ,  Molecular Life Sciences ,   North Terrace
  • Biography/ Background

    2016 - Present Associate Professor, School of Biological Science

    2016 - Present Deputy Director, Australian Centre for Antimicrobial Resistance Ecology

    2014 - Present Deputy Director, Research Centre for Infectious Disease

    2012 - Present Group Leader - Chemical Biology of Bacterial Pathogens Laboratory

    2008 - 2011 Independent Research Fellow (Discipline of Microbiology and Immunlogy, University of Adelaide)

    2005 - 2008 Senior Postdoctoral Research Associate (Nuffield Department of Clinical Laboratory Sciences, Oxford)

    2002 - 2005 Postdoctoral Research Associate (Department of Biochemistry, Oxford)

    1998 - 2002 Ph.D (University of Queensland, Australia)

  • Qualifications

    2002 – Ph.D, University of Queensland, Australia.

    1997 – Bachelor of Science (Honours, Class I), University of Queensland, Australia.

  • Awards & Achievements

    2017 - Order of Merit for Mid-Career Research Excellence (University of Adelaide)

    2017 - Australian Research Council Future Fellowship

    2011 - Research Career Development Network Mid-Career Researcher Award (University of Adelaide)

    2007 - EPA Cephalosporin Junior Research Fellow (Linacre College, University of Oxford)

  • Research Interests

    For the most up to date information see my website

  • Publications

    For the most current publication information, please see Google Scholar or see my Researcher ID

    Social media article metrics for publications are reported by Altmetric

    Key publications relevant to current research

    Refereed Journal Articles

    1. Plumptre, C.D., Hughes, C.E., Harvey, R.M., Eijkelkamp, B.A., McDevitt, C.A. and Paton, J.C. (2014) Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity. doi:10.1128/IAI.02155-14 [pdf]
    2. van Wonderen J.H., McMahon R.M., O'Mara M.L., McDevitt C.A., Thomson A.J., Kerr I.D., MacMillan F., and Callaghan R. (2014) The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal. 281:2190-201 [pdf]
    3. Eijkelkamp, B.A., Morey, J.R., Ween, M.P., Ong, C.Y., McEwan, A.G., Paton, J.C., and McDevitt, C.A. (2014) Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniaePLoS ONE. 9:e89427 [pdf]
    4. Plumptre, C.D.*, Eijkelkamp, B.A.*, Morey, J.R., Behr, F., Couñago, R.M., Ogunniyi, A.D., Kobe B., O'Mara, M.L., Paton, J.C., and McDevitt, C.A. (2014) AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology. DOI: 10.1111/mmi.12504 [pdf] [*equal first author]
    5. Couñago, R.M.*, Ween, M.P.*, Begg S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., and McDevitt, C.A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology. 10:35-41. [pdf] [*equal first author]
      Access the recommendation on F1000Prime
    6. Pollock, N.L., McDevitt, C.A., Collins, R.F., Niesten, P.H.M., Prince, S., Kerr, I.D., Ford, R.C., and Callaghan, R. (2014) Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochim Biophys Acta. 1838:134-47. [pdf]
    7. Heng S., McDevitt C.A., Stubing D.B., Whittall J.J., Thompson J.G., Engler T.K., Abell A.D. and Monro T.M. (2013) Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules. 14:3376-9. [pdf]
    8. McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., and Paton, J.C. (2011) A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens 7:e1002357 [pdf]
      Research highlight in Nature Reviews Microbiology - David, R. (2012)
    9. Ogunniyi, A.D., Mahdi, L.K., Jennings, M.P., McEwan, A.G., McDevitt C.A., Van der Hoek, M.B., Bagley, C.J., Hoffman, P., Gould, K.A., and Paton, J.C. (2010) Central role of manganese in regulation of stress responses, physiology and metabolism in Streptococcus pneumoniae. Journal of Bacteriology 192:4489-97. [pdf]
    10. McDevitt, C.A., Collins, R.F., Kerr, I.D., and Callaghan, R. (2009) Purification and structural analyses of ABCG2. Advanced Drug Delivery Reviews 61:57-65 [pdf]
    11. McDevitt, C.A., Crowley, E.H., Hobbs, G., Starr, K., Kerr, I.D., and Callaghan, R. (2008) Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? FEBS Journal 275:4354-62 [pdf]
    12. McDevitt, C.A., Shintre, C.A., Grossmann, G.J., Pollock, N.L., Prince, S.M., Callaghan, R., Ford, R.C. (2008) Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography. FEBS Letters 582:2950-6 [pdf]
    13. McDevitt, C.A., Sargent, F., Palmer, T., and Berks, B. C. (2006) Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS Journal 273:5656-68 [pdf]
    14. McDevitt, C.A., Collins R.F., Conway M., Modok S., Storm J., Kerr I.D., Ford R.C. and Callaghan R., (2006) Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure 14:1623-32 [pdf]
    15. Gohlke, U., Pullen, L., McDevitt, C.A., Porcelli, I., Palmer, T., Sabil, H.R. and Berks, B.C. (2005) The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc. Natl. Acad. Sci. 102:10482-10486 [pdf]
    16. McDevitt, C.A., Hicks, M.G., Palmer, T., and Berks, B.C. (2005) Biochemical characterisation of null phenotype mutant Tat receptor complexes. Biochemical Biophysical Research Communications 329:693-8
    17. McEwan, A.G., Bernhardt P.V., Creevey, N., Hanson, G.R., and McDevitt, C.A. (2004) Ion motive electron transfer pathways involving type II molybdoenzymes of the DMSO reductase family. BBA-Bioenergetics 1658:16.
    18. McDevitt, C. A., Hanson, G. R., Noble, C., Cheesman, M. R., and McEwan, A. G. (2002) Characterisation of the redox centres from Dimethylsulfide Dehydrogenase of Rhodovulum sulfidophilum. Biochemistry 41:15234-44
    19. McEwan, A.G., Ridge, J.P., McDevitt, C.A., and Hugenholtz, P. (2002) The DMSO reductase family of microbial molybdenum enzymes; molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal 19:3-21
    20. McDevitt, C.A., Hugenholtz, P., Hanson, G.R., and McEwan, A.G. (2002) Molecular analysis of Dimethylsulfide Dehydrogenase from Rhodovulum sulfidophilum; its place in the DMSO reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology 44:1575-87
    21. Hanson, G.R., McDevitt, C.A., and McEwan, A.G. (2001) Dimethylsulfide dehydrogenase from Rhodovulum sulfidophilum: EPR spectroscopy and biochemical analysis reveal its place in the DMSO reductase family of molybdenum enzymes. Journal of Inorganic Biochemistry 86:248.
    22. McDevitt, C., Burrell, P.C., Blackall, L.L., and McEwan, A. G. (2000) Aerobic nitrate respiration in a nitrite oxidising bioreactor. FEMS Microbiology Letters 184:113-118.



    1. Couñago R.L., McDevitt C.A., Ween M.P., Kobe B. (2012) Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets 3:1400-10 [pdf]
    2. Lewis, V.G., Ween, M.P., and McDevitt C.A. (2012) The role of ATP-binding cassette transporters in bacterial pathogenicity. Protoplasma. 249:919-942 [pdf]
    3. Lehane, A.M., McDevitt, C.A., Kirk, K., and Fidock, D.A. (2012) Degrees of chloroquine resistance in Plasmodium - is the redox system involved? Int. J. Paras. Drugs Drug Res. 1:47-57 [pdf]
    4. Crowley, E. H., McDevitt, C.A., and Callaghan, R. (2009) Generating inhibitors of P-glycoprotein (ABCB1); where to now? In “Multi-Drug Resistance in Cancer” (editor J. Zhou) Methods Mol Bio. 596:405-32 [pdf]
    5. McDevitt, C.A., and Callaghan R. (2007) How can we best use structural information on P-glycoprotein to design inhibitors? Pharm and Therap. 113:429-41 [pdf]
    6. McEwan, A.G., Kappler, U. and McDevitt, C.A. (2004) Molybdenum enzymes in bacterial respiration. In “Respiration in Archaea and Bacteria” (editor D. Zannoni) Kluwer Academic Publishers. p.175-202

  • Professional Associations

    The Biochemical Society (UK) (Local Liason)

    The Australian Biochemical and Molecular Biology Society

    The Adelaide Protein Group (Treasurer)

    The Australian Society for Biophysics

    COST Action CM1306 - Understanding Movement and Mechanism in Molecular Machines

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Entry last updated: Sunday, 7 Jan 2018

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