Dr Claire Jessup

Dr Claire Jessup
 Position Adjunct Senior Lecturer
 Org Unit Medical Specialties
 Email claire.jessup@adelaide.edu.au
 Location Floor/Room 9 ,  RAH - East Wing ,   Royal Adelaide Hospital
  • Qualifications

    BBiotech(Hons); PhD

  • Awards & Achievements

    2001 MF & MH Joyner Postgraduate Scholarship in Medicine, South Australia
    2001 Peter Meffin Memorial Postgraduate Research Prize, Flinders University
    2004 Young Investigator Award, Transplantation Society for Australia and New Zealand
    2004 International Society for Eye Research Travel Fellowship
    2004 Australian Society of Immunology, Student Travel Bursary

    2006 CJ Martin Biomedical NHMRC Overseas Postdoctoral Training Award
    2010 Young Investigator Award, Transplantation Society for Australia and New Zealand
    2011 SA Young Tall Poppy Science Award
    2012 Vice Chancellor's Award for Early Career Researchers, Flinders University
    2013 Highest Impact Paper of the Year, Centre for Neuroscience, Flinders University

  • Teaching Interests

    Bachelor of Medicine Year 1, University of Adelaide - CBL Tutor

    Doctor of Medicine (MD) Years 1&2, Flinders University - Lecturer, Histology & Gross Anatomy

    Body Systems MMED3932, Human Musculoskeletal Anatomy MMED3941, Flinders University - Lecturer, Gross Anatomy

  • Research Interests

    My research laboratory is based at Flinders University in the Department of Histology & Anatomy (School of Medicine). My contact details are here http://www.flinders.edu.au/people/claire.jessup.

    As an Adjunct Senior Lecturer with the University of Adelaide, I work collaboratively with the Islet Transplantation and Dendritic Cell Biology Laboratory run by Assoc Prof Toby Coates (http://www.adelaide.edu.au/directory/patrick.coates).

    My primary research interests focus on the vasculature of the pancreatic islet. The dense network of capillaries (stained in green in Figure below) is crucial for the sensitive detection of blood glucose and release of insulin. Many islets die when they are disconnected from their blood supply for transplantation purposes - limiting the success of islet transplantation. In collaboration with Dr Claudine Bonder in the Centre for Cancer Biology (http://www.centreforcancerbiology.org.au/research/laboratories/vascular-biology-and-cell-trafficking-laboratory/) we are investigating the use of endothelial progenitor cells to swiftly reconnect blood supply to transplanted islets and improve their function and survival.

     Intraislet vascular endothelial cells

  • Research Funding

    2015

     

     

     

    2011

    NHMRC Project Grant #APP1101761

    "Desmoglein-2; a lifeline to treat diabetes"

    CIs: CS Bonder, PTH Coates, N Voelcker, CF Jessup

     

    Project Grant - Medvet Laboratories

    CI: CF Jessup; AI: PTH Coates, CS Bonder

     

    $609,064

     

     

     

    $276,000

    2010

    Project Grant - Centre for Stem Cell Research, Robinson Institute

    CI: PTH Coates, CS Bonder, CF Jessup

    $75,000

    2010

    Research Grant - Robinson Institute Collaborative Research Funding Scheme

    CI: CF Jessup, CS Bonder, PTH Coates

    $12,000

    2010

    Australian Federation of University Women Postdoctoral Grant

    CF Jessup

    $5,000

    2010

    Research Grant – TSANZ/Amgen

    S Kireta, HS Eng, M Stephenson, CF Jessup, G Bennett, G Russ, PTH Coates

    $50,000

    2009

    Young Scientist Research Travel Grant - Juvenile Diabetes Research Foundation

    CF Jessup

    $2,500

    2005

    Overseas Postdoctoral Training Fellowship (Biomedical CJ Martin) – NHMRC

    CF Jessup

    $304,118

     

  • Publications

    Rojas-Canales, D., Penko, D., Myo Min, K. K., Parham, K. A., Peiris, H., Haberberger, R. V., Pitson, S. M., Drogemuller, C., Keating, D. J., Grey, S. T., Coates, P. T., Bonder, C. S. and Jessup, C. F. (2016) Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. Diabetes (in press)

    Peiris, H., Duffield, M.D., Fadista, J., Jessup, C.F., Kashmir, V., Genders, A., et al. (2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ß-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PloS Genetics, 12(5) pp. e1006033. 

    Coleman, M., Jessup, C.F., Bridge, J., Overgaard, N., Penko, D., Walters, S., et al. (2016). Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65(5) pp. 1328-1340.
    [10.2337/db15-1418]

    Penko, D., Rojas-Canales, D., Mohanasundaram, D., Peiris, G., Sun, W., Drogemuller, C. ... and Jessup C. F. (2015). Endothelial progenitor cells enhance islet engraftment, influence beta cell function and modulate islet connexin 36 expression. CELL TRANSPLANTATION, 24(1) pp. 37-48.

    Canlas, J., Holt, P., Carroll, A., Rix, S.M., Ryan, P.J., Davies, L., et al. (2015). Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in Molecular Neuroscience, 8 pp. Art: 29. 

    Raghupathi, R., Jessup, C.F., Lumsden, A.L. and Keating, D.J. (2015). Fusion Pore Size Limits 5-HT Release from Single Enterochromaffin Cell Vesicles. Journal of Cellular Physiology

    Peiris, G.D., Bonder, C.S., Coates, P.T., Keating, D.J. and Jessup, C.F. (2014). The ß-cell/EC axis: how do islet cells talk to each other? Diabetes, 63(1) pp. 3-11.
    [10.2337/db13-0617] [Scopus]

    Peiris, H., Dubach, D., Jessup, C.F., Unterweger, P., Raghupathi, R., Muyderman, H.C., et al. (2014). RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells. Oxidative Medicine and Cellular Longevity, 2014 pp. ArticleID 520316.

    Appleby, S.L., Jessup, C.F., Mortimer, L.A., Brereton, H.M., Coster, D.J., Tan, C.K., et al. (2013). Expression of an anti-CD4 single chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats. British Journal of Ophthalmology, 97(1) pp. 101-105.

    Hughes, A., Mohanasundaram, D.M., Kireta, S., Jessup, C.F., Drogemuller, C.J. and Coates, P.T. (2013). Insulin-Like Growth Factor-II (IGF-II) Prevents Proinflammatory Cytokine-Induced Apoptosis and Significantly Improves Islet Survival After Transplantation. Transplantation, 95(5) pp. 671-678.

    Fernandes, R.A., Shore, D.A., Vuong, M.T., Yu, C., Zhu, X., Pereira-Lopes, S., et al. (2012). T Cell Receptors are Structures Capable of Initiating Signalin in the Absence of Large Conformational Rearrangements. Journal of Biological Chemistry, 287(16) pp. 13324-13335.  

  • Professional Associations

    The Transplantation Society of Australia and New Zealand (TSANZ)

    Australasian Society for Immunology (ASI)

    Australian Society for Medical Research (ASMR)

    Australasian Gene Therapy Society

    Australian Diabetes Society

    Women Leaders in Transplantation member (The Transplantation Society)

  • Community Engagement

    2000-2004     Postgraduate Research in the School of Medicine (PRISM), Flinders University

                        Deputy Convenor, Executive committee member

    2001-2004     Gus Fraenkel Medical Library Committee, Flinders University

                        Postgraduate student representative,

    2003             ASMR Medical Research Week, Public display and information booth, Adelaide, SA

    2004             Biotechnology 10 year reunion committee, Flinders University

    2006-2007     Females in Engineering Science and Technology (FEST), Oxford University, UK

                        Member

    2009             Early Career Researchers Group, Basil Hetzel Institute, Adelaide, SA

                        Founder

    2009             BHI Research Day committee,

    2000-2009     Adelaide Wildcats Netball Club (Vice president, committee member, player)

    2009             BHI Strategic Research Directions Working Group, TQEH, SA (Member)

    2009-2011     Australian Society for Immunology, Annual Meeting Organising Committee 2011

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Entry last updated: Monday, 18 Dec 2017

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