Dr Claire Jessup
|Position||Adjunct Senior Lecturer|
|Org Unit||Medical Specialties|
RAH - East Wing
Royal Adelaide Hospital
Awards & Achievements
2001 MF & MH Joyner Postgraduate Scholarship in Medicine, South Australia
2001 Peter Meffin Memorial Postgraduate Research Prize, Flinders University
2004 Young Investigator Award, Transplantation Society for Australia and New Zealand
2004 International Society for Eye Research Travel Fellowship
2004 Australian Society of Immunology, Student Travel Bursary
2006 CJ Martin Biomedical NHMRC Overseas Postdoctoral Training Award
2010 Young Investigator Award, Transplantation Society for Australia and New Zealand
2011 SA Young Tall Poppy Science Award
2012 Vice Chancellor's Award for Early Career Researchers, Flinders University
2013 Highest Impact Paper of the Year, Centre for Neuroscience, Flinders University
Bachelor of Medicine Year 1, University of Adelaide - CBL Tutor
Doctor of Medicine (MD) Years 1&2, Flinders University - Lecturer, Histology & Gross Anatomy
Body Systems MMED3932, Human Musculoskeletal Anatomy MMED3941, Flinders University - Lecturer, Gross Anatomy
My research laboratory is based at Flinders University in the Department of Histology & Anatomy (School of Medicine). My contact details are here http://www.flinders.edu.au/people/claire.jessup.
As an Adjunct Senior Lecturer with the University of Adelaide, I work collaboratively with the Islet Transplantation and Dendritic Cell Biology Laboratory run by Assoc Prof Toby Coates (http://www.adelaide.edu.au/directory/patrick.coates).
My primary research interests focus on the vasculature of the pancreatic islet. The dense network of capillaries (stained in green in Figure below) is crucial for the sensitive detection of blood glucose and release of insulin. Many islets die when they are disconnected from their blood supply for transplantation purposes - limiting the success of islet transplantation. In collaboration with Dr Claudine Bonder in the Centre for Cancer Biology (http://www.centreforcancerbiology.org.au/research/laboratories/vascular-biology-and-cell-trafficking-laboratory/) we are investigating the use of endothelial progenitor cells to swiftly reconnect blood supply to transplanted islets and improve their function and survival.
NHMRC Project Grant #APP1101761
"Desmoglein-2; a lifeline to treat diabetes"
CIs: CS Bonder, PTH Coates, N Voelcker, CF Jessup
Project Grant - Medvet Laboratories
CI: CF Jessup; AI: PTH Coates, CS Bonder
Project Grant - Centre for Stem Cell Research, Robinson Institute
CI: PTH Coates, CS Bonder, CF Jessup
Research Grant - Robinson Institute Collaborative Research Funding Scheme
CI: CF Jessup, CS Bonder, PTH Coates
Australian Federation of University Women Postdoctoral Grant
Research Grant – TSANZ/Amgen
S Kireta, HS Eng, M Stephenson, CF Jessup, G Bennett, G Russ, PTH Coates
Young Scientist Research Travel Grant - Juvenile Diabetes Research Foundation
Overseas Postdoctoral Training Fellowship (Biomedical CJ Martin) – NHMRC
Rojas-Canales, D., Penko, D., Myo Min, K. K., Parham, K. A., Peiris, H., Haberberger, R. V., Pitson, S. M., Drogemuller, C., Keating, D. J., Grey, S. T., Coates, P. T., Bonder, C. S. and Jessup, C. F. (2016) Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. Diabetes (in press)
Peiris, H., Duffield, M.D., Fadista, J., Jessup, C.F., Kashmir, V., Genders, A., et al. (2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ß-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PloS Genetics, 12(5) pp. e1006033.
Coleman, M., Jessup, C.F., Bridge, J., Overgaard, N., Penko, D., Walters, S., et al. (2016). Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65(5) pp. 1328-1340.
Penko, D., Rojas-Canales, D., Mohanasundaram, D., Peiris, G., Sun, W., Drogemuller, C. ... and Jessup C. F. (2015). Endothelial progenitor cells enhance islet engraftment, influence beta cell function and modulate islet connexin 36 expression. CELL TRANSPLANTATION, 24(1) pp. 37-48.
Canlas, J., Holt, P., Carroll, A., Rix, S.M., Ryan, P.J., Davies, L., et al. (2015). Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in Molecular Neuroscience, 8 pp. Art: 29.
Raghupathi, R., Jessup, C.F., Lumsden, A.L. and Keating, D.J. (2015). Fusion Pore Size Limits 5-HT Release from Single Enterochromaffin Cell Vesicles. Journal of Cellular Physiology
Peiris, G.D., Bonder, C.S., Coates, P.T., Keating, D.J. and Jessup, C.F. (2014). The ß-cell/EC axis: how do islet cells talk to each other? Diabetes, 63(1) pp. 3-11.
Peiris, H., Dubach, D., Jessup, C.F., Unterweger, P., Raghupathi, R., Muyderman, H.C., et al. (2014). RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells. Oxidative Medicine and Cellular Longevity, 2014 pp. ArticleID 520316.
Appleby, S.L., Jessup, C.F., Mortimer, L.A., Brereton, H.M., Coster, D.J., Tan, C.K., et al. (2013). Expression of an anti-CD4 single chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats. British Journal of Ophthalmology, 97(1) pp. 101-105.
Hughes, A., Mohanasundaram, D.M., Kireta, S., Jessup, C.F., Drogemuller, C.J. and Coates, P.T. (2013). Insulin-Like Growth Factor-II (IGF-II) Prevents Proinflammatory Cytokine-Induced Apoptosis and Significantly Improves Islet Survival After Transplantation. Transplantation, 95(5) pp. 671-678.
Fernandes, R.A., Shore, D.A., Vuong, M.T., Yu, C., Zhu, X., Pereira-Lopes, S., et al. (2012). T Cell Receptors are Structures Capable of Initiating Signalin in the Absence of Large Conformational Rearrangements. Journal of Biological Chemistry, 287(16) pp. 13324-13335.
The Transplantation Society of Australia and New Zealand (TSANZ)
Australasian Society for Immunology (ASI)
Australian Society for Medical Research (ASMR)
Australasian Gene Therapy Society
Australian Diabetes Society
Women Leaders in Transplantation member (The Transplantation Society)
2000-2004 Postgraduate Research in the School of Medicine (PRISM), Flinders University
Deputy Convenor, Executive committee member
2001-2004 Gus Fraenkel Medical Library Committee, Flinders University
Postgraduate student representative,
2003 ASMR Medical Research Week, Public display and information booth, Adelaide, SA
2004 Biotechnology 10 year reunion committee, Flinders University
2006-2007 Females in Engineering Science and Technology (FEST), Oxford University, UK
2009 Early Career Researchers Group, Basil Hetzel Institute, Adelaide, SA
2009 BHI Research Day committee,
2000-2009 Adelaide Wildcats Netball Club (Vice president, committee member, player)
2009 BHI Strategic Research Directions Working Group, TQEH, SA (Member)
2009-2011 Australian Society for Immunology, Annual Meeting Organising Committee 2011
- ASI flyer - flyer.tif [4.1MB] (image/tiff)
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Entry last updated: Monday, 18 Dec 2017
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