Dr Hu Zhang

Dr Hu Zhang
  • Biography/ Background

    Career Summary:

    • January 2014 -   Senior lecturer in School of Chemical Engineering of The University of Adelaide, Australia
    • March 2009-January 2014 Lecturer in School of Chemical Engineering of The University of Adelaide, Australia
    • September 2006-March 2009 Research Associate in the Institute of Science and Technology for Medicine, Keele University, UK

    • March 2004-September 2006 Postdoctoral Fellow in the Department of Biochemical Engineering, University College London, UK

    • October 2000-February 2004 Ph.D. in Biochemical Engineering, University College London, UK

    • September 1998-October 2000 Lecturer in Chemical Engineering, Dalian Nationalities University, China

    • September 1995-August 1998 Master in Biochemical Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

    • September 1991-July 1995 Bachelor in Chemical Engineering, Dalian University of Technology, China

  • Teaching Interests

    Currently I am teaching:

    • Chem Eng 3030 Simulation and Concept Design

    • Chem Eng 7054 Simulation and Concept Design (PG)

      Chem Eng 2014 Heat & Mass Transfer

    • Chem Eng 3025 Pharmaceutical Plant Design and Process Engineering

    • Chem Eng 3021 Advanced Pharmaceutical Unit Operation

    • Chem Eng 3023 Chemical Engineering Unit Operations Lab

    • Chem Eng 3026 Pharmaceutical Engineering Projects and Experimental Design III

    Past Courses

    • Chem Eng 3035 Chemical Engineering Application A (Particle and Fluid Dynamics)

    • Chem Eng 3024 Professional Practice III (Project only)

  • Research Interests

    Tissue engineering, Regenerative medicines, biomaterials, nanomaterials, antibacterial coating, antibacterial nanocomposites, bioreactor design, bioprocess scale up,bioprocess scale down, mammalian cell culture, fermentation technology, gene delivery, drug delivery, enzymatic catalysis, nanobiocatalysis, multiphase fluid dynamics, computational fluid dynamics, population balance equations

    More information can be obtained from Bio-Nano-Tech group website.

    If you are interested in studying your PhD or master by research with me, please contact me for more information.

    Postgraduate Scholarships are available at the Graduate Centre.

  • Publications

    1. Book Chapters:

    1.   Mellati, A. & Zhang, H. 2015 Expansion of stem cells by nano tissue engineering, in “Stem Cell NanoEngineering, ed. Baharvand, H. Chapter 14: 243-263. John Wiley & Sons, Inc. DOI: 10.1002/9781118540640.ch14


    2. Selected Referred Journal Publications


    1.     Mellati A.; Kiamahalleh M.V.; Madani S.H.; Dai  S.; Bi J.; Jin B.; Zhang H. Poly (N-isopropylacrylamide) hydrogel/chitosan scaffold hybrid for three-dimensional stem cell culture and cartilage tissue engineering. Journal of Biomedical Materials Research Part A. 2016, DOI: 10.1002/jbm.a.35810.

    2.     Mission M.; Dai, S.; Jin, B.; Zhang, H. Manipulation of nanofiber-based β-galactosidase nanoenvironment for enhancement of galacto-oligosaccharide production. Journal of Biotechnology, 2016, DOI: 10.1016/j.jbiotec.2016.02.014.

    3.     Navvab Kashani, M., Elekaei, H., Zivkovic, V., Zhang., H., Biggs, M.J. Explicit numerical simulation-based study of the hydrodynamics of micro-packed beds. Chemical Engineering Science, 2016, DOI: 10.1016/j.ces.2016.02.003.

    4.     Mellati, A., Valizadeh Kiamahalleh, M., Dai, S., Bi, J., Jin, B., & Zhang, H. (2016). Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide). Materials Science and Engineering C, 59, 509-513.

    5.     Misson, M., Du, X., Jin, B., & Zhang, H. (2016) Dendrimer-like Nanoparticles Based β-galactosidase Assembly for Enhancing Its Selectivity towards Transgalactosylation. Enzyme and Microbial Technology DOI: 10.1016/j.enzmictec.2015.12.008.

    6.     Misson, M., Jin, B., Chen, B., & Zhang, H. (2015). Enhancing enzyme stability and metabolic functional ability of β-galactosidase through functionalized polymer nanofiber immobilization. Bioprocess and Biosystems Engineering, 38(10), 1915-1923. doi:10.1007/s00449-015-1432-5

    7.     Misson, M., Zhang, H., & Jin, B. (2015). Nanobiocatalyst advancements and bioprocessing applications. Journal of the Royal Society Interface, 12(102), 20 pages. doi:10.1098/rsif.2014.0891

    8.     Modra, K., Dai, S., Zhang, H., Shi, B., & Bi, J. (2015). Polycation-mediated gene delivery: Challenges and considerations for the process of plasmid DNA transfection. Engineering in Life Sciences, 15(5), 489-498. doi:10.1002/elsc.201400043

    9.     Zhang, H., Cui, X., Bi, J., Dai, S., & Ye, H. (2015). Single-cell analysis for bioprocessing. Engineering in Life Sciences, 15(6), 582-592. doi:10.1002/elsc.201400155

    10.   Mellati, M, Zhang, H, Bo, J, Dai, S, Jin, B. 2014 A Biodegradable Thermosensitive Hydrogel with Tuneable

    Properties for Mimicking Three-Dimensional Microenvironments of Stem Cells, RSC Advances, 4: 63951-63961.

    11.   Shen, Z., Mellati, A., Bi, J., Dai, S., Zhang, H. 2014 A thermal responsive cationic nanogel based platform for cell three-dimensional culture and recovery. RSC Advances, 4: 29146-29156.

    12.   Shi, B., Zhang, H., Bi, J.,             Qiao, S.Z., Dai, S. 2014 Intracellular Microenvironment Responsive Label-free Autofluorescent Nanogels for Traceable Gene Delivery. Advanced Healthcare Materials. 3: 839–1848. DOI: 10.1002/adhm.201400187

    13.   Shi, B., Zhang, H., Bi, J., Dai, S.  2014 Endosomal pH responsive polymers for efficient cancer targeted gene therapy. Colloids and Surfaces B: Biointerfaces. 119: 55-65, doi:10.1016/j.colsurfb.2014.04.005

    14.   Shi, B., Zhang, H., Bi, J., Dai, S., Qiao, S.Z. 2014 Intracellular Microenvironment Responsive Polymer: A Multiple-stage Transport Platform for High-performance Gene Delivery. Small. 10(5):871-877.

    15.   Shi, B., Zhang, H., Bi, J., and Dai, S. 2013 Developing a chitosan supported imidazole Schiff-base for high-efficiency gene delivery. Polymer Chemistry. 4, 840-850.

    16.   Qi, N., Zhang, H., Zhang, K., 2013 CFD Simulation of Particle Suspension in the Stirred Tank Reactor with a Smith Turbine, Particuology, 11(3): 317–326.

    17.   Qi, N., Zhang, K., Xu, G., Yang Y., Zhang, H. 2013 CFD-PBE simulation of gas-phase hydrodynamics in a gas-liquid-solid combined loop reactor, Petroleum Science, 10(2): 251-261.

    18.   Elliott, P., Billingham, S. Bi, J., Zhang, H. 2013 Quality by design for biopharmaceuticals: a historical review and guide for implementation. Pharmaceutical Bioprocessing, 1(1): 105-122.

    19.   Zhang, H., Kay, A., Forsyth, N.F, Liu K.K., El Haj, A.J. 2012 Gene expression of single human mesenchymal stem cells in response to fluid shear, Journal of Tissue Engineering, 3(1): 2041731412451988

    20.   Shen, Z.; Bi, J.; Shi, B.; Nguyen D.; Xian, C. J.; Zhang, H.; Dai, S. 2012 Exploring thermal reversible hydrogels for stem cell expansion in three-dimension. Soft Matter, 2012, 8, 3250-3258.

    21.   Shen, Z.Y., Shi, B., Zhang, H., Bi, J, Dai, S. 2012 Exploring low-positively charged thermosensitive copolymers as gene delivery vectors. Soft Matter. 8: 1385-1394.

    22.   Shi, B., Shen, Z.Y., Zhang, H., Bi, J., and Dai, S. 2012 Exploring N-Imidazolyl-O-Carboxymethyl Chitosan for High Performance Gene Delivery. Biomacromolecules, 13, 146-153.

    23.   Qi, N., Zhang, K., Xu, G., Yang, Y., Zhang, H. 2012 Structure optimization of gas-liquid combined loop reactor using a CFD-PBE coupled model. Petroleum Science, 9(3): 379-388.

    24.   Shi, B., Deng, L., Shi, X., Dai, S., Zhang, H., Wang, Y., Bi, J., Guo, M. (2011) The enhancement of neural stem cell survival and growth by co-culturing with expanded Sertoli cells in vitro, Biotech. Prog. 28(1):196-205

    25.   Qi, N., Zhang, H., Bo, J., Zhang, K. 2011 CFD Modelling of Hydrodynamics and Degradation Kinetics in an Annular Slurry Photocatalysis Reactor for Wastewater Treatment. Chemical Engineering Journal, 172(1): 84-95.

    26.   Zhang, H.; Dai, S.; Bi, J.; Liu, K. K. 2011 Biomimetic three-dimensional microenvironment for controlling stem cell fate. Interface Focus 1:792-803.

    27.   Qi, N., Wu, G., Wang, H., Zhang, K., Zhang, H. 2010 CFD simulation of mixing characteristics in the stirred tank by Smith Turbine. CIESC Journal, 61(9), 2305-2313.

    28.   Qi, N., Wang, H., Zhang, K., Zhang, H. 2010 Numerical Simulation of fluid dynamics in the stirred tank by the SSG Reynolds Stress Model. Frontier in Chemical Engineering, 4(4): 506-514.

    29.   Zhang, H., Liu, K.K. 2010 An optical-manipulation technique for cells in physiological flows. J. Biol. Phys., 36: 135-143.

    30.   Zhang, H., Wang, W.X., Quan, C.S. Fan, S.D. 2010 Engineering Considerations for Process Development in Mammalian Cell Cultivation. Curr. Pharm. Biotechnol., 11(1), 103-112.

    31.   Zhang, K., Qi, N., Jin, J.Q., Lu, C.X., Zhang, H. 2010 Gas holdup and bubble dynamics in a three-phase internal loop reactor with external slurry circulation. Fuel,  89:1361-1369.

    32.   Barret, T., Wu, A., Zhang, H., Levy, S., Lye, G. 2010 Microwell engineering characterisation for mammalian cell culture process development, Biotech. Bioeng., 105(2):260-75.

    33.   Zhang, H., Zhang, K., Fan, S.D. 2009 CFD simulation coupled with population balance equations for areated stirred bioreactors. Eng. Life  Sci., 9: 421-430.

    34.   Qi, N., Zhang, K., Song, Q., Gao, X., Zhang, H., Lu, J. 2009 2D and 3D simulation of fluid dynamics in the bubble reactor for liquid fuel synthesis: comparisons against experiments. Energ. Source. Part A, 31: 1598-1611.

    35.   Lu, C.X., Qi, N.N., Zhang, K., Jin, J.Q., Zhang, H. 2009 Experiment and CFD simulation on gas holdup characteristics in an internal loop reactor with external liquid circulation, Int. J. Chem. React. Eng., Vol 7: A3.

    36.   Zhang, H., Liu, K.K., El Haj, A., 2009 Opto-mechanical manipulation of stem cells. Open NanoMed J., 2: 10-14.

    37.   Zhang, H. & Liu, K.K. 2008 Optical tweezers in single cells. Journal of Royal Society Interface. 5(24):671-690.

    38.   Zhang, H., Liu, KK, El Haj A, 2008 Optical manipulation of stem cells. European Cells and Materials 16 (Suppl 3), 98.

    39.   Zhang, H., Lamping, S.R., Pickering, S.C.R., Lye, G. J., Shamlou,P.A. 2008 Engineering characterisation of a single well from 24-well and 96-well microtitre plates. Biochemical Engineering Journal, 40: 138-149.

    40.   E, C.L, Fan, Y.P., Zhang, K., Zhang, H. 2008, Concentration profile of gas phase in the feed injection zone of a FCC riser, Prog. Nat. Sci., 18, 1285-1291.

    41.   Zhang, H. Kong, S., Booth, A., Boushaba, R., Levy, S.M., Hoare, M., 2007, Prediction of plasmid DNA degradation in pump operations using an ultra-scale-down device. Biotechnology Progress. 23 (4): 858 -865

    42.   Biddlecombe, J., Craig, A.V., Zhang, H.,  Uddin, S., Mulot, S.,  Fish, B.C.,  Bracewell, D.G. 2007, Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment. Biotechnology Progress. 23: 1218-1222.

    43.   Meacle*, F.J., Zhang*, H., Papantoniou, I. Ward, J.M., Titchener-Hooker, N.J., Hoare, M., 2007, Degradation of supercoiled plasmid DNA within a capillary device, Biotechnology and Bioengineering, 97(5): 1148-1157 (Equal Contribution)

    44.   Liu, H.Y., Zhang, H., et al. 2006, Purifcation and properties of a poly (β-hydroxybutyrate) deploymerase from Penicillium sp. Journal of Polymers and the Environment, 14: 419-426.

    45.   Zhang, H., Williams-Dalson, W., Keshavarz-Moore, E., Ayazi Shamlou, P., 2005CFD analysis of mixing and gas-liquid mass transfer in shake flasks. Biotechnology and Applied Biochemistry, 41(1) 1-8.

    46.   Zhang, H. Wang, W., Fan, S.D. 2005, Power consumption and mixing in a miniaturised bioreactor, Progress in Nature Science, 15(supp1), 117-123.

    47.   Wei, Y., Song, J., Shi, M., Zhang, H. 2005, Numerical simulation of the asymmtric gas phase flow field in a volute cyclone separator, Progress in Nature Science, 15(supp1), 98-104.

    48.   Zhang H., Ayazi Shamlou P., 2004, Characterisation of the engineering flow in a miniaturised bioreactor by computational fluid dynamics, Chemical Research in Chinese Universities, 20(4): 489-493.

    49.   Sarkar, S., Zhang, H., Levy, S.M., Hart., S., Hails, H.C., Tabor, A.B., Ayazi Shamlou, P., 2003, Prediction of particle size distribution of  formulated plamsid DNA complexes  using Monte Carlo simulations, Biotechnology and Applied Biochemistry, 38: 95-102.

    50.   Maguire, L.A., Zhang, H., Ayazi Shamlou, P., 2003, Preparation of small unilamellar vesicles (SUV) and biophysical characterisation of their complexes with poly-L-lysine condensed plasmid DNA, Biotechnology and Applied Biochemistry, 37:73-81.

    51.   Lamping, S.R, Zhang, H., Ayazi Shamlou, P, 2003, Design of a prototype micro-litre bioreactor for high throughput automated bioprocessing, Chemical Engineering Science,58:747-758.

    52.    Zhang, K., Zhang, H., Lovick, J., Zhang J.Y., Zhang, B.J., 2002, Numerical computation and experimental verification of the jet region in a fluidized bed, Ind. Eng. Chem. Res, 41, 3696-3704.

    53.   Zhang, H., Lamping, S.R, Ayazi Shamlou, P, 2002, Numerical simulation of mixing in a micro-well scale bioreactor by computational fluid dynamics, Chemical Research in Chinese Universities, 18(2): 113-116.

    54.   Zhang, H., Du, Y.G., Yu, X.J., 1999, Preparation of chitooligosaccharides from chitosan by an enzyme mixture, Carbohydrate Research, 320(3~4): 257~260.

  • Professional Associations

    Member of IChemE and ISPE

  • Media Expertise

    ExpertiseTissue engineering, regenerative medicines, bioprocess scale up, bioprocess scale down, bioreactor design, fermentation technology, mammalian cell culture, separation and purification, formulation, enzymatic catalysis, nanobiocatalysis, gene delivery, drug delivery, computational fluid dynamics, mathematical modelling, chromatography, membrane separation
    NotesBioprocessing Network SA coordinator International Society of Pharmaceutical Engineering, Adelaide Chapter Faculty advisor Institute of Chemical Engineers, SA committee member

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Entry last updated: Sunday, 24 May 2020