Dr Mitchell Goldsworthy

Dr Mitchell Goldsworthy
 Position NHMRC-ARC Dementia Research Fellow
 Org Unit Adelaide Medical School
 Email mitchell.goldsworthy@adelaide.edu.au
 Telephone +61 8 8313 1323
 Location ,   North Terrace
  • Qualifications

    2008   Bachelor of Science (Biomedical Science). University of Adelaide.

    2009   Honours (Physiology). University of Adelaide.

    2013   PhD (Medicine). University of Adelaide.

     

  • Research Funding

    Research Grants and Fellowships (including year of award)

    2016:    Yulgilbar Postdoctoral Excellence Award. CIA; $30,000.

                  University of Adelaide Interdisciplinary Research Grant. CIB; $42,015.

    2015:    NHMRC-ARC Dementia Research Development Fellowship (APP1102272). 4 years; $603,767.

                  NHMRC Early Career Fellowship (APP1112738 – relinquished to accept APP1102272).

    2014:    AADRF Project Grant (DGP14-98). CIA; $50,000.

    2013:    AADRF Full Postdoctoral Research Fellowship (DGP13F00034). 2 years; $220,000.

                  AADRF Project Grant (DGP1300078 – relinquished to accept DGP13F00034).

    2012:    German Academic Exchange Service (DAAD) Research Grant. €4,100.

     

    Prizes, Awards, and Travel Grants

    2016:    School of Medicine Research Travel Award. University of Adelaide. $1,000.

                  Robinson Institute Travel Grant. Robinson Research Institute, University of Adelaide. $550.

    2015:    Robinson Institute Travel Grant. Robinson Research Institute, University of Adelaide. $2,500.

    2014:    Robinson Institute Travel Grant. Robinson Research Institute, University of Adelaide. $2,000.

    2013:    Robinson Institute Travel Grant. Robinson Research Institute, University of Adelaide. $900.

                  Symbiotic Devices Student Travel Award. Australasian Brain Stimulation. $200.

                  Dean’s Commendation for Doctoral Thesis Excellence. University of Adelaide.

    2012:    AUGU/RC Heddle Award. University of Adelaide. $2,000.

                  Research Abroad Scholarship. University of Adelaide. $2,000.

                  Robinson Institute Travel Grant. Robinson Research Institute, University of Adelaide. $1,300.

    2011:    Faculty of Health Sciences Postgraduate Travelling Fellowship. University of Adelaide. $1,700.

    2010:    Australian Postgraduate Award. $75,000.

                  Robinson Institute PhD Scholarship. Robinson Research Institute, University of Adelaide. $15,000.

  • Publications

    Refereed Publications

    Van Dam, J., Garrett, A., Schneider, L., Buisman-Pijlman, F., Short, M., Hodyl, N., . . . Pitcher, J. (2018). Variability of the cortisol awakening response and morning salivary oxytocin in late adolescence. Journal of Neuroendocrinology, 30(11), 9 pages. doi:10.1111/jne.12645

    Tse, N., Goldsworthy, M., Ridding, M., Coxon, J., Fitzgerald, P., Fornito, A., & Rogasch, N. (2018). The effect of stimulation interval on plasticity following repeated blocks of intermittent theta burst stimulation. Scientific Reports, 8(1), 1-10. doi:10.1038/s41598-018-26791-w

    Moezzi, B., Schaworonkow, N., Plogmacher, L., Goldsworthy, M. R., Hordacre, B., McDonnell, M., . . . Triesch, J. (2018). Simulation of electromyographic recordings following transcranial magnetic stimulation. Journal of Neurophysiology, 120(5), 2532-2541. doi:10.1152/jn.00626.2017

    Van Dam, J., Garrett, A., Schneider, L., Hodyl, N., Goldsworthy, M., Coat, S., . . . Pitcher, J. (2018). Reduced Cortical Excitability, Neuroplasticity, and Salivary Cortisol in 11–13-Year-Old Children Born to Women with Gestational Diabetes Mellitus. EBioMedicine, 31, 143-149. doi:10.1016/j.ebiom.2018.04.011

    Smith, A., Goldsworthy, M., Wood, F., Olds, T., Garside, T., & Ridding, M. (2018). High-intensity Aerobic Exercise Blocks the Facilitation of iTBS-induced Plasticity in the Human Motor Cortex. Neuroscience, 373, 1-6. doi:10.1016/j.neuroscience.2017.12.034

    Hordacre, B., & Goldsworthy, M. (2018). Commentary: cooperation not competition: bihemispheric tDCS and fMRI show role for ipsilateral hemisphere in motor learning. Frontiers in Human Neuroscience, 12, 97-1-97-3. doi:10.3389/fnhum.2018.00097

    Moezzi, B., & Goldsworthy, M. (2018). Commentary: consistency of EEG source localization and connectivity estimates. Frontiers in Neuroscience, 12(MAR), 147-1-147-3. doi:10.3389/fnins.2018.00147

    Hordacre, B., Goldsworthy, M., Vallence, A., Darvishi, S., Moezzi, B., Hamada, M., . . . Ridding, M. (2017). Variability in neural excitability and plasticity induction in the human cortex: a brain stimulation study. Brain Stimulation, 10(3), 588-595. doi:10.1016/j.brs.2016.12.001

    Hordacre, B., Moezzi, B., Goldsworthy, M., Rogasch, N., Graetz, L., & Ridding, M. (2017). Resting state functional connectivity measures correlate with the response to anodal transcranial direct current stimulation. European Journal of Neuroscience, 45(6), 837-845. doi:10.1111/ejn.13508

    Opie, G., Rogasch, N., Goldsworthy, M., Ridding, M., & Semmler, J. (2017). Investigating TMS–EEG indices of long-interval intracortical inhibition at different interstimulus intervals. Brain Stimulation, 10(1), 65-74. doi:10.1016/j.brs.2016.08.004

    Goldsworthy, M., & Hordacre, B. (2017). Dose-dependency of transcranial direct current stimulation: implications for neuroplasticity induction in health and disease. The Journal of Physiology, 595(11), 3265-3266. doi:10.1113/jp274089

    Hordacre, B., Rogasch, N., & Goldsworthy, M. (2016). Commentary: Utility of EEG measures of brain function in patients with acute stroke. Frontiers in Human Neuroscience, 10(DEC2016), 3 pages. doi:10.3389/fnhum.2016.00621

    Goldsworthy, M. R., Hordacre, B., & Ridding, M. C. (2016). Minimum number of trials required for within- and between-session reliability of TMS measures of corticospinal excitability. Neuroscience, 320, 205-209. doi:10.1016/j.neuroscience.2016.02.012

    Goldsworthy, M. R., Vallence, A. M., Yang, R., Pitcher, J. B., & Ridding, M. C. (2016). Combined transcranial alternating current stimulation and continuous theta burst stimulation: a novel approach for neuroplasticity induction. European Journal of Neuroscience, 43(4), 572-579. doi:10.1111/ejn.13142

    Goldsworthy, M. R., Vallence, A. M., Hodyl, N. A., Semmler, J. G., Pitcher, J. B., & Ridding, M. C. (2016). Probing changes in corticospinal excitability following theta burst stimulation of the human primary motor cortex. Clinical Neurophysiology, 127(1), 740-747. doi:10.1016/j.clinph.2015.06.014

    Schneider, L. A., Goldsworthy, M. R., Cole, J. P., Ridding, M. C., & Pitcher, J. B. (2016). The influence of short-interval intracortical facilitation when assessing developmental changes in short-interval intracortical inhibition. Neuroscience, 312, 19-25. doi:10.1016/j.neuroscience.2015.10.057

    Hordacre, B., Ridding, M. C., & Goldsworthy, M. R. (2015). Response variability to non-invasive brain stimulation protocols. Clinical Neurophysiology, 126(12), 2249-2250. doi:10.1016/j.clinph.2015.04.05

    Pitcher, J. B., Doeltgen, S. H., Goldsworthy, M. R., Schneider, L. A., Vallence, A. M., Smith, A. E., . . . Ridding, M. C. (2015). A comparison of two methods for estimating 50% of the maximal motor evoked potential. Clinical Neurophysiology. doi:10.1016/j.clinph.2015.02.011

    Vallence, A. M., Goldsworthy, M. R., Hodyl, N. A., Semmler, J. G., Pitcher, J. B., & Ridding, M. C. (2015). Inter- and intra-subject variability of motor cortex plasticity following continuous theta-burst stimulation. Neuroscience, 304, 266-278. doi:10.1016/j.neuroscience.2015.07.043

    Goldsworthy, M. R., Pitcher, J. B., & Ridding, M. C. (2014). Spaced Noninvasive Brain Stimulation: Prospects for Inducing Long-Lasting Human Cortical Plasticity.. Neurorehabilitation and neural repair. doi:10.1177/1545968314562649

    Goldsworthy, M. R., Müller-Dahlhaus, F., Ridding, M. C., & Ziemann, U. (2014). Inter-subject variability of LTD-like plasticity in human motor cortex: A matter of preceding motor activation. Brain Stimulation, 7(6), 864-870. doi:10.1016/j.brs.2014.08.004

    Clow, A., Law, R., Evans, P., Vallence, A. M., Hodyl, N. A., Goldsworthy, M. R., . . . Ridding, M. C. (2014). Day differences in the cortisol awakening response predict day differences in synaptic plasticity in the brain. Stress, 17(3), 219-223. doi:10.3109/10253890.2014.905533

    Vallence, A. M., & Goldsworthy, M. (2014). Can noninvasive brain stimulation enhance function in the ageing brain?. Journal of Neurophysiology, 111(1), 1-3. doi:10.1152/jn.00088.2013

    Goldsworthy, M. R., Müller-Dahlhaus, F., Ridding, M. C., & Ziemann, U. (2014). Resistant Against De-depression: LTD-Like Plasticity in the Human Motor Cortex Induced by Spaced cTBS.. Cerebral cortex (New York, N.Y. : 1991), Online, 1-11. doi:10.1093/cercor/bht353

    Smith, A., Goldsworthy, M., Garside, T., Wood, F., & Ridding, M. (2014). The influence of a single bout of aerobic exercise on short-interval intracortical excitability. Experimental Brain Research, 232(6), 1875-1882. doi:10.1007/s00221-014-3879-z

    Goldsworthy, M., Pitcher, J., & Ridding, M. (2013). Neuroplastic modulation of inhibitory motor cortical networks by spaced theta burst stimulation protocols. Brain Stimulation, 6(3), 340-345. doi:10.1016/j.brs.2012.06.005

    Goldsworthy, M. R., & Vallence, A. M. (2013). The role of β-amyloid in Alzheimer's disease-related neurodegeneration. Journal of Neuroscience, 33(32), 12910-12911. doi:10.1523/JNEUROSCI.2252-13.2013

    Goldsworthy, M., Pitcher, J., & Ridding, M. (2012). A comparison of two different continuous theta burst stimulation paradigms applied to the human primary motor cortex. Clinical Neurophysiology, 123(11), 2256-2263. doi:10.1016/j.clinph.2012.05.001

    Goldsworthy, M., Pitcher, J., & Ridding, M. (2012). The application of spaced theta burst protocols induces long-lasting neuroplastic changes in the human motor cortex. European Journal of Neuroscience, 35(1), 125-134. doi:10.1111/j.1460-9568.2011.07924.x

    Bignold, J., Deans-Costi, G., Goldsworthy, M., Robertson, C., McEvoy, R., Catcheside, P., . . . Mercer, J. (2009). Poor long-term patient compliance with the Tennis Ball Technique for treating positional obstructive sleep apnea. The Journal of Clinical Sleep Medicine, 5(5), 428-430. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270598900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1f051b2c0ced71d786748f61000f9895

     

  • Professional Interests

    My research employs various non-invasive brain stimulation (TMS, tES) and recording (EEG) techniques to characterise the neurophysiological determinants of cognitive function in healthy ageing and dementia. The overarching aim of this research is to provide new mechanistic insights into the roles of brain connectivity and plasticity in supporting late life cognitive health, with the potential to inform novel strategies for dementia prevention and therapy.

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Entry last updated: Monday, 4 Feb 2019

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