Dr Toby Coates

Dr Toby Coates
 Position Professor of Medicine - Renal Transplantation
 Org Unit Medicine
 Email toby.coates@health.sa.gov.au
 Telephone +61 8 8222 0934
 Location Floor/Room 7 ,  Adelaide Health and Medical Sciences ,   North Terrace
  • Biography/ Background

    Laboratory: Centre for Clinical and Experimental Transplantation.

    Senior Members: Professor Toby Coates; Professor Randall Faull; Associate Professor Stephen McDonald; Dr Chen Au Peh; Dr Shilpa Jesudason; Dr Rob Carroll and Principal Scientist Chris Drogemuller.

  • Qualifications

    • MBBS, University of Adelaide
    • PhD, University of Adelaide
    • Fellow of the Royal Australasian College of Physicians


  • Awards & Achievements

    Awards from 2000 onwards

    • Don and Lorraine Jacquot Travelling Fellowship 2000
    • The Royal Australasian College of Physicians 
    • Young Investigator Award 2000
    • The Transplantation Society of Australia and New Zealand
    • The Jansen-Cilag Travelling Fellowship 2001
    • The Transplantation Society of Australia and New Zealand
    • The American Society of Transplantation Travel Award 2001
    • Don and Lorraine Jacquot Travelling Fellowship 2002
    • The Royal Australasian College of Physicians 
    • CJ Martin Fellowship 2002-2005 
    • National Health and Medical Research Council of Australia
    • South Australian Tall Poppy Science Award 2004
    • Government of South Australia
    • Young New Key Opinion Leader in Transplantation 2007
    • The International Transplantation Society
    • Mentor: Mentee Award 2011
    • The International Transplantation Society
    • Honorary Secretary 2009-2013
    • Australian and New Zealand Society of Transplantation
    • Ian McKenzie Prize for Outstanding Contribution in Transplantation
    • Transplantation Society of Australia and New Zealand 2013
    • Mentor:Mentee Award 2014
    • The International Transplantation Society
    • Mentor:Mentee Award 2016
    • The International Transplantation Society
    • President-Elect Transplantation Society of Australia and New Zealand 2017-2018
    • President Transplantation Society of Australia and New Zealand 2019-2021
  • Teaching Interests

    Current PhD Candidates

    • Mr Bron Lett BSc (Hons) MS, University of Adelaide 2013-
    • Mr Sebastian Stead BSc (Hons), University of Adelaide 2015-


  • Research Interests

    Centre for Clinical and Experimental Transplantation


    Our laboratory is part of the School of Medicine in the Central Northern Adelaide Renal and Transplantation Service on the 9th Floor of the Royal Adelaide Hospital (East Wing). The group is run by Assoc Prof Toby Coates and our labs are situated in the Hanson Centre Laboratories on Frome Road.

    Type 1 diabetes is a chronic, life-long autoimmune disease affecting over 140,000 Australians, where the insulin-producing islets of Langerhans in the pancreas are destroyed. The incidence of this disease is increasing and, even with daily insulin therapy, diabetic patients are at greater risk of serious complications including heart attack, stroke, ocular damage and kidney disease.

    Our area of research focuses on the isolation and transplantation of healthy pancreatic islets as an innovative treatment and potential cure for type 1 diabetes. As part of the Australian Islet Transplantation Consortium, the laboratory prepares and performs assays on purified islets that are ultimately transplanted into patients. To date, the Consortium has transplanted 15 patients across Australia. Factors limiting the success of islet transplantation include suboptimal engraftment, immune reaction and rapid cell death post transplant. Our laboratory is interested in identifying and combating the causes of islet cell death. We are also interested in basic islet biology, and how function can be protected/quickly restored following transplantation.

    The laboratory is based in the Hanson Institute and are part of the Basil Hetzel Institute at the Queen Elizabeth Hospital site and the Robinson Institute. We reside within the Central Northern Adelaide Renal and Transplantation Service, where scientists regularly attend departmental meetings and many of the clinicians are heavily involved with research projects. We recently won a NHMRC project grant beginning in 2009 and we have active collaborations with groups bringing expertise in vascular biology including Dr Claudine Bonder, Centre for Cancer Biology and Cellular Neuroscience Dr Damien Keating, Flinders University. 


    A major new research initiative is the recently announced Collaborative Research Centre for Cell Therapy Manufacturing (CRC-CTM) - a research collaboration with the University of South Australia, University of Sydney and University of Melbourne. Details and research opportunities - http://www.ctmcrc.com or contact Professor Coates directly.


    Current projects in the laboratory

    Gene therapy to prevent apoptosis in transplanted pancreatic islets: 

    Apoptosis is the major cause of islet cell death post-transplantation. Anti-apoptotic factors, such as insulin-like growth factor II (IGF-II), have the potential to protect transplanted islets. This project involves transferring DNA encoding protective genes, such as IGF-II, to islet cells using an adeno-associated virus gene therapy vector. Function and viability of transduced islets will be evaluated using techniques such as ELISA, cytokine challenge and flow cytometry. Transduced islets will be assayed for in vivo function in a diabetic NOD-SCID model.

    Role of zinc transporters in pancreatic islets:
    Another limitation of islet transplantation is the damage that occurs during isolation due to mechanical and enzymatic stress. This leads to apoptosis and an insufficient number of cells to meet metabolic needs post-transplantation. Zinc plays a vital role in DNA replication, enzyme activity and cellular protection against apoptosis and oxidative stress. Zinc is very high in pancreatic beta cells (the cells that secrete insulin) and is important in synthesis, storage and release of insulin. We have shown that levels of zinc transporter molecules on the surface of islet beta cells vary greatly among diabetic and non-diabetic patients. Our aim is to measure the RNA and protein levels of various zinc transporters in isolated and cultured islets and correlate this with protection of insulin production. The importance of zinc transporters in vivo will be assessed using a diabetic mice model.

    Endothelial progenitor cells to promote the success of pancreatic islet transplantation in the rat:
    The islets of the pancreas are one of the most heavily vascularised tissues in the body, requiring 10% of the pancreatic blood flow despite only making up 1% of the pancreatic mass. As such, islets become rapidly hypoxic (inadequate oxygen supply) following isolation. Endothelial progenitor cells (EPC) are multipotent cells that act as a circulating ‘repair kit' for vasculature, assisting with the repair of endothelium and the growth of new vessels in hypoxic or damaged tissue. EPC may improve the revascularization and engraftment of isolated islets following transplantation. The aim of this project is to characterize EPC by flow cytometry using antibodies against cell surface markers (including VEGF receptor 2, CXCR4, CD146, VCAM-1, monocyte markers (CD14) and stem cell markers (CD133, CD34)) and a 3D tube-forming assay in Matrigel. The cells will be evaluated for their potential to improve revascularisation when cotransplanted with pancreatic islets in a rodent model of diabetes.

    Tolerogenic dendritic cells for transplantation:
    Dendritic cells (DC) are the sentinels of the immune system, potently directing the immune response towards a reactive or tolerant outcome. As such, DC are vitally important following the transplantation of organs and tissues. Our group has a long history in working with DC. Current projects involve characterizing the DC subsets present in the draining lymph nodes following kidney and islet transplantation. Another aim involves genetically modifying DC to induce a tolerogenic phenotype, and coadministering these DC to prevent transplant rejection.

    Mesenchymal Stem Cells in Kidney Repair and Transplantation:
    In this project, we are exploring the therapeutic potential of ovine and human mesenchymal stem cells in kidney injury, with a particular emphasis on ischaemia reperfusion injury. Magnetic resonance imaging (MRI) is used to provide in vivo imaging of iron labelled MSC in a project supported by the Large Animal Research Imaging Facility (LARIF) in SA Pathology.

  • Research Funding

    • Flinders Research Foundation 
    • Multiple Sclerosis Society of Australia 
    • National Institutes of Health (USA) Allergy and Infectious Disease 
    • National Health and Medical Research Council: CJ Martin Fellowship 
    • Muriel T Gunn Research Trust 
    • Don and Lorraine Jacquot 
    • Perpetual Trustees of Australia 
    • CellCept Australia Research
    • Australian Hotels Association 
    • National Health and Medical Research Council (NHMRC)
    • Juvenile Diabetes Research Foundation (JDRF)/ Australian Federal Government 
    • The Queen Elizabeth Hospital Research Foundation
    • Collaborative Centre for Stem Cell Research 
    • TSANZ 
    • Medvet Laboratories
    • Diabetes UK 
    • Royal Adelaide Hospital Research Foundation 
    • Kidney Research UK 
    • Kidney Transplantation Population 
    • Australian Government Department of Department of Industry, Innovation, Science, Research and Tertiary Education Collaborative Research Centre for Cell Therapy Manufacturing (CRC-CTM) 
    • Juvenile Diabetes Research Foundation International
    • Hospital Research Foundation
    • Royal Adelaide Hospital Research Foundation
    • Kidney, Transplant , Diabetes Research Australia


  • Publications

    Kim J, Scaffidi J, Coates PT.Off the beaten track: defining the developmental path of T cells through the human Thymus Kidney Int. 2020 Jun 20:S0085-2538(20)30698-0.


    Kim, J, Perkins GB, Coates PT Evolutionary immunology: how your ancestry can affect your kidney transplant Kidney Int 2020 Jul;98(1):45-47


    Coates PT, Wong G The forgotten fallen: painful reality of a pandemic Kidney Int  2020 Jun 15;S0085-2538(20)30659-1


    Soraru ,J, Isbel N, Wong G3, Coates PT, Mantha M, Abraham A,  Juneja R, Hsu D, Brown F, Bose B, Mudge D, Carroll RP, Kausman J, Hughes P, Barbour T, Durkan A, Mount, P, Lee, D, Larkins, N,  Ranganathan D, Lim WH. Baseline characteristics of patients with atypical haemolytic uraemic syndrome (aHUS): The Australian cohort in a global aHUS registry Nephrology (Carlton) 2020 May 7.

     doi: 10.1111/nep.13722


    Coates PT, Wong G, Drueke T, Rovin B, Ronco P. Early experience with COVID-19 in kidney transplantation Kidney Int 2020 Jun;97(6):1074-1075


    Jalalonmuhali, M, Carroll, RP, Tsiopelas, E, Clayton, P, Coates PT Development of de novo HLA donor specific antibodies (HLA-DSA), HLA antibodies (HLA-Ab) and allograft rejection post blood transfusion in kidney transplant recipients Hum Immunol 2020 Jul;81(7):323-329.


    Coates PT, Wong G Current controversies in nephrology-how to crossmatch for transplantation? Kidney Int 2020 Apr;97(4):662-663


    Kim, J  Hope, C  Gantumur, N  Perkins, G  Stead, S  Yue, Z  Liu, X  Asua, A  Kette, F  Penko, D  Drogemuller, C  Carroll, R  Barry, S  Wallace, G  Coates, PT. Encapsulation of Human Natural and Induced Regulatory TCells in IL2 and CCL1 Supplemented AlginateGelMA Hydrogel for 3D Bioprinting. Advanced Functional Materials. 2020 30(15): DOI 10.1002/adfm.202000544.


    Sivanathan K, Coates PT. Improving human kidney function in renovascular disease with mesenchymal stem cell therapy Kidney Int 2020 Apr;97(4):655-656


    Forget A, Rojas D, Waibel M, Pencko D, Gunenthiran S, Ninan N, Loudovaris T, Drogemuller C, Coates PT, Voelcker NH, Blencowe A. Facile preparation of tissue engineering scaffolds with pore size gradients using the muesli effect and their application to cell spheroid encapsulation.  J Biomed Mater Res B Appl Biomater. 2020 Feb 12. doi: 10.1002/jbm.b.34581.


    Salehi T, Coates PT. “Class effect: dapagliflozin reduces cardiovascular and kidney events”. Kidney Int. 2019 Oct 10. pii: S0085-2538(19)30989-5. doi: 10.1016/j.kint.2019.08.035.


    Bateman SM, Coates PT, Jesudason S. “Three Pregnancies After Transplantation: An 84-year-old Kidney Is the Gift That Keeps Giving Life.” Transplantation. 2019 Dec;103(12):e397-e398. doi:


    Collins MG, Symonds EL, Bampton PA, Coates PT. Fecal Immunochemical “Screening for Advanced Colorectal Neoplasia in Patients with CKD: Accurate or Not”

    J Am Soc Nephrol. 2019 Nov;30(11):2275. doi: 10.1681/ASN.2019070710

    Pavathuparambil Abdul Manaph N, Sivanathan KN, Nitschke J, Zhou XF, Coates PT, Drogemuller CJ. “An overview on small molecule-induced differentiation of mesenchymal stem cells into beta cells for diabetic therapy.” Stem Cell Res Ther. 2019 Sep 23;10(1):293. doi: 10.1186/s13287-019-1396-5.


    Dias BH, Rana AAM, Olakkengil SA, Russell CH, Coates PT, Clayton PA, Bhattacharjya S. Development and implementation of an enhanced recovery after surgery protocol for renal transplantation. ANZ J Surg. 2019 Oct;89(10):1319-1323. doi: 10.1111/ans.15461.


    Smith G, Gujari D, Russell O, Palmer L, Toews M, Wong G, Lim W, McDonald S, Clayton P, Martin D, Coates PT. “International travel by Australians for overseas transplantation”. Med J Aust. 2019 Nov;211(10):460. doi: 10.5694/mja2.50333.


    Rao NN, Stokes MB, Rajwani A, Ullah S, Williams K, King D, Macaulay E, Russell CH, Olakkengil S, Carroll RP, Faull RJ, Teo KSL, McDonald SP, Worthley MI, Coates PT.Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients”. Circulation. 2019 May 2. doi: 10.1161/CIRCULATIONAHA.118.038505.

    Rao NN, Wilkinson C, Morton M, Bennett GD, Russ GR, Coates PT, Jesudason SSuccessful pregnancy in a recipient of an ABO-incompatible renal allograft”. Obstet Med. 2019 Mar;12(1):42-44


    Carroll RP, Deayton S, Emery T, Munasinghe W, Tsiopelas E, Fleet A, Lake M, Humphreys I, Jalalonmuhali M, Coates PT. “Proactive treatment of angiotensin receptor antibodies in kidney transplantation with plasma exchange and/or candesartan is safe and associated with excellent graft survival at 4 years: A single centre Australian experience”. Hum Immunol. 2019 Apr 20. pii: S0198-8859(19)30173-9


    Liu X, Carter SD, Renes MJ, Kim J, Rojas-Canales DM, Penko D, Angus C, Beirne S, Drogemuller CJ, Yue Z, Coates PT, Wallace GG. Development of a Coaxial 3D Printing Platform for Biofabrication of Implantable Islet-Containing Constructs. Adv Healthc Mater. 2019 Jan 11:e1801181


    Burzava ALS, Forget A, Harding FJ, Cockshell MP, Penko D, Rouzaud C, Ahmadi V, Marina PF, Rojas-Canales D, Bonder CS, Coates PTH, Waibel M, Thomas HE, Kay TW, Loudovaris T, Blencowe A, Voelcker NH. Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets. Biointerphases. 2019 Jan 30;14(1):011002


    Nelson AJ, Dundon BK, Worthley SG, Richardson JD, Puri R, Wong DTL, Coates PT, Faull RJ, Worthley MI. “End-stage renal failure is associated with impaired coronary microvascular function”. Coron Artery Dis. 2019 Mar 13. doi: 10.1097/MCA.0000000000000727



    Lim WH, Coates PT, Russ GR, Russell C, He B, Jaques B, Pleass H, Chapman JR, Wong G. Weekend effect on early allograft outcome after kidney transplantation- a multi-centre cohort study. Transpl Int. 2018 Nov 14. doi: 10.1111/tri.13377


    Lee MH, Ward GM, MacIsaac RJ, Howe K, Holmes-Walker DJ, Anderson P, Radford T, Coates PT, Kay TW, O'Connell PJ, Goodman DJ. Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation. Transplant Direct. 2018 Oct 23;4(11):e401.


    Pavathuparambil Abdul Manaph N, Al-Hawwas M, Bobrovskaya L, Coates PT, Zhou XF. Urine-derived cells for human cell therapy. Stem Cell Res Ther. 2018 Jul 11;9(1):189

    Stead SO, Kireta S, McInnes SJP, Kette FD, Sivanathan KN, Kim J, Cueto-Diaz EJ, Cunin F, Durand JO, Drogemuller CJ, Carroll RP, Voelcker NH, Murine and Human Dendritic Cell Targeting Nanoparticles for in Vivo Generation of Regulatory T-Cells. Coates PT  ACS Nano. 2018 Jul 24;12(7):6637-6647.

    Rao NN, Coates PT. Cardiovascular Disease After Kidney Transplant. Semin Nephrol. 2018 May;38(3):291-297 

    Sivanathan KN, Coates PT. IL-17A-induced mesenchymal stem cells have promising therapeutic value for clinical translation. Kidney Int. 2018 Apr;93(4):771-773

    Rojas-Canales DM, Waibel M, Forget A, Penko D, Nitschke J, Harding FJ, Delalat B, Blencowe A, Loudovaris T, Grey ST, Thomas HE, Kay TWH, Drogemuller CJ, Voelcker NH, Coates PTOxygen-permeable microwell device maintains islet mass and integrity during shipping. Endocr Connect. 2018 Mar;7(3):490-503. 

    Ross MJ, Coates PTUsing CRISPR to inactivate endogenous retroviruses in pigs: an important step toward safe xenotransplantation? Kidney Int. 2018 Jan;93(1):4-6.

    Stead SO, McInnes SJP, Kireta S, Rose PD, Jesudason S,  Rojas-Canales D,, Warther D,  Cunin F, Durand JO,  Drogemuller CJ, Carroll RP Coates PT, Voelcker NH, “Manipulating human dendritic cell phenotype and function with targeted porous silicon nanoparticles” Biomaterials 2018 Feb;155:92-102

     Do Nguyen HT, Wong G, Chapman JR, McDonald SP, Coates PT, Watson N, Russ GR, D'Orsogna L, Lim WH. The Association Between Broad Antigen HLA Mismatches, Eplet HLA Mismatches and Acute Rejection After Kidney Transplantation. Transplant Direct. 2016 Nov 23;2(12):e120

    Clayton PA, Coates PT. Are sensitized patients better off with a desensitization transplant or waiting on dialysis? Kidney Int. 2017 Jun;91(6):1266-1268


    Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR. Dominant protection from HLA-linked autoimmunity by antigen specific regulatory T cells. Nature. 2017 May 11;545(7653):243-247 2017


     Geyer MC, Coates PT, Khurana S, Chen JW, Kay TW, Balamurugan AN, Couper JJ, Radford T, Drogemuller CJ, Loudovaris T, Pathi R, Wilks MJ, Couper RT. First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia. Pancreas. 2017 Mar;46(3):e18-e20.


     Forget A, Waibel, M, Rojas-Canales, DM, Chen, S, Kawazoe, N, Harding F.J., Loudovaris, T, Coates, PT, Blencowe, A, Chen , G, Voelcker, NH. IGF-2 coated porous collagen microwells for the culture of pancreatic islets. J Mat Chem 2017;5:220-225


    Rojas-Canales D, Penko D, Myo Min KK, Parham KA, Peiris H, Haberberger RV, Pitson SM, Drogemuller C, Keating DJ, Grey ST, Coates PT, Bonder CS, Jessup CF. Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. Diabetes. 2017 Feb 7. pii: db160837. doi: 10.2337/db16-0837



    Yue Z, Liu X, Coates PT, Wallace GG. Advances in printing biomaterials and        living cells: implications for islet cell transplantation. Curr Opin Organ Transplant. 2016 Oct;21(5):467-75.

    Sivanathan KN, Gronthos S, Grey ST, Rojas-Canales D, Coates PT.

    Immunodepletion and hypoxia preconditioning of mouse compact bone cells as a      novel protocol to isolate highly immunosuppressive Mesenchymal Stem Cells.

           Stem Cells Dev. 2016 Dec 21. Doi: 10.1089/scd.2016.0180

    Delalat B, Rojas-Canales DM, Rasi Ghaemi S, Waibel M, Harding FJ, Penko D,

           Drogemuller CJ, Loudovaris T, Coates PT, Voelcker NH. A Combinatorial   Protein Microarray for Probing Materials Interaction with Pancreatic Islet Cell  Populations. Microarrays (Basel). 2016 Aug 10;5(3). pii: E21. doi: 10.3390/microarrays5030021

    Carroll RP, Riceman M, Hope CM, Zeng A, Deayton S, Bennett GD,  Coates PT.Angiotensin II type-1 receptor antibody (AT1Rab) associated humoral rejection and the effect of peri operative plasma exchange and candesartan. Hum Immunol. 2016 Aug 16. pii: S0198-8859(16)30418-9. doi: 10.1016/j.humimm.2016.08.009

    Snelgrove SL, Lo C, Hall P, Lo CY, Alikhan MA, Coates PT, Holdsworth SR, Hickey MJ, Kitching AR. Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury. Transplantation. 2016 Aug 5

    Amin T, Coates PT, Barbara J, Hakendorf P, Karim N. Prevalence of Hypercalcaemia in a Renal Transplant Population: A Single Centre Study. Int J Nephrol. 2016;2016:7126290.

    Wyatt CM, Coates PT, Reeves WB “Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans?” Kidney Int. 2016 Jul;90(1):10-3.    

    Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.  PLoS Genet. 2016 May 19;12(5):e1006033. doi: 10.1371/journal.pgen.1006033

    Krishnan AR, Wong G, Chapman JR, Coates PT, Russ GR, Pleass H, Russell C, He B, Lim WH. Prolonged Ischemic Time, Delayed Graft Function, Graft and Patient Outcomes in Live-Donor Kidney Transplant Recipients. Am J Transplant. 2016 Apr 2. doi: 10.1111/ajt.13817

    Lim WH, Chapman JR, Coates PT, Lewis JR, Russ GR, Watson N, Holdsworth R, Wong G. HLA-DQ Mismatches and Rejection in Kidney Transplant Recipients. Clin J Am Soc Nephrol. 2016 Mar 31. pii: CJN.11641115.

    Coleman MA, Jessup CF, Bridge JA, Overgaard NH, Penko D, Walters S, Borg DJ, Galea R, Forbes JM, Thomas R, Coates PT, Grey ST, Wells JW, Steptoe RJ.  Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes. 2016 Mar 9. pii: db151418.  

    Lim WH, McDonald SP, Coates PT, Chapman JR, Russ GR, Wong G. . Maternal compared to paternal donor kidneys are associated with poorer graft outcomes after kidney transplantation. Kidney Int. 2016 Mar;89(3):659-65

    Hope CM, Troelnikov A, Hanf W, Jesudason S, Coates PT, Heeger PS, Carroll RP. Peripheral natural killer cell and allo-stimulated T-cell function in kidney transplant recipients associate with cancer risk and immunosuppression-related complications.Kidney Int. 2015 Dec;88(6):1374-1382   

    Sivanathan KN, Rojas-Canales DM, Hope CM, Krishnan R, Carroll RP, Gronthos S, Grey ST, Coates PT. Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function. Stem Cells.  2015 Sep;33(9):2850-63 


    Jobert A, Rao N, Deayton S, Bennett GD, Brealey J, Nolan J, Carroll RP, Dragun D, Coates PT. Nephrology (Carlton). 2015 Mar;20 Suppl 1:10-2. doi: 10.1111/nep.12421.

    Hope CM, Coates PT, Carroll RP. Immune profiling and cancer post transplantation.World J Nephrol. 2015 Feb 6;4(1):41-56.

    Dundon BK, Pisaniello AD, Nelson AJ, Maia M, Teo KS, Worthley SG, Coates PT, Russ GR, Faull RJ, Bannister K, Worthley MI. Dobutamine Stress Cardiac MRI for Assessment of Coronary Artery Disease Prior to Kidney Transplantation. Am J Kidney Dis. 2015 Feb 26. pii: S0272-6386(15)00423-0. doi:

    Fuss A, Hope CM, Deayton S, Bennett GD, Holdsworth R, Carroll RP, Coates PT. C4d Negative Antibody Mediated Rejection With High Anti-Angiotensin II Type I Receptor Antibodies In Absence Of Donor Specific Antibodies. Nephrology (Carlton). 2015 Feb 26. doi: 10.1111/nep.12441

    Marathe CS, Drogemuller CJ, Marathe JA, Loudavaris T, Hawthorne WJ, O'Connell PJ, Radford T, Kay TW, Horowitz M, Coates PT, Torpy DJ. Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients. Horm Metab Res. 2014 Oct 28

    Dundon BK, Pisaniello AD, Nelson AJ, Maia M, Teo KS, Worthley SG, Coates PT, Russ GR, Faull RJ, Bannister K, Worthley MI. Dobutamine Stress Cardiac MRI for Assessment of Coronary Artery Disease Prior to Kidney Transplantation. Am J Kidney Dis. 2015 Feb 26. pii: S0272-6386(15)00423-0. doi: 

    Pathiraja V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska KRodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW, Mannering SI. Proinsulin specific, HLA-DQ8 and HLA-DQ8 transdimer restricted, CD4+ T cells infiltrate the islets in type 1 diabetes. Diabetes. 2014 Aug 25. pii: DB_140858.

    • Hughes A, Rojas-Canales D, Drogemuller C, Voelcker NH, Grey ST, Coates PT. IGF2: an endocrine hormone to improve islet transplant survival.J Endocrinol. 2014 Apr 22;221(2):201-8. doi: 10.1530/JOE-13-0557. Print 2014. PMID: 24756096
    • Hanf W, Bonder CS, Coates PT. Transplant Glomerulopathy: The Interaction of HLA Antibodies and Endothelium. J Immunol Res. 2014;2014:549315.
    • Li JY, McNicholas K, Yong TY, Rao N, Coates PT, Higgins GD, Carroll RP, Woodman RJ, Michael MZ, Gleadle JM. BK Virus Encoded MicroRNAs Are Present in Blood of Renal Transplant Recipients With BK Viral Nephropathy. Am J Transplant. 2014 Apr 14. doi: 10.1111/ajt.12694.
    • Sivanathan KN, Gronthos S, Rojas-Canales D, Thierry B, Coates PT. Interferon-Gamma Modification of Mesenchymal Stem Cells: Implications of Autologous and Allogeneic Mesenchymal Stem Cell Therapy in Allotransplantation. Stem Cell Rev. 2014 Feb 9.
    • Hope CM, Grace BS, Pilkington KR, Coates PT, Bergmann IP, Carroll RP. The immune phenotype may relate to cancer development in kidney transplant recipients. Kidney Int. 2014 Jan 15. doi: 10.1038/ki.2013.538
    • Peiris H, Bonder CS, Coates PT, Keating DJ, Jessup CF. The β-Cell/EC Axis: How Do Islet Cells Talk to Each Other? Diabetes. 2014 Jan;63(1):3-11.
    • Coates PT, Ross M, Schlöndorff D Kidney international web focus on transplantation. Kidney Int. 2014 Feb;85(2):227-9.Penko D, Rojas Canales D, Mohanasundaram D, Peiris HS, Sun WY, Drogemuller CJ, Keating DJ, Coates PT, Bonder CS, Jessup CF. "Endothelial progenitor cells enhance islet engraftment, influence beta cell function and modulate islet connexin 36 expression. Cell Transplant. 2013 Sep 10
    • Multicentre Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. O'Connell, PJ, Goodman, D, Loudovaris, T, Thomas H, Gunton, J, Drogemuller, CJ, Ward, G, Torpy, DJ, Coates PT, Kay T. Am J Transplant 2013 July;13(7):1850-8
    • Insulin-Like Growth Factor-II (IGF-II) Prevents Proinflammatory Cytokine-Induced Apoptosis and Significantly Improves Islet Survival After Transplantation. Hughes A, Mohanasundaram D, Kireta S, Jessup CF, Drogemuller CJ, Coates PT. Transplantation 2013 Mar 15;95(5):671-678.
    • Consensus guidelines on the testing and clinical management issues associated with HLA and Non-HLA antibodies in transplantation. Tait BD, Süsal C, Gebel HM, Nickerson PW, Zachary AA, Claas FH, Reed EF, Bray RA, Campbell P, Chapman JR, Coates PT, Colvin RB, Cozzi E, Doxiadis II, Fuggle SV, Gill J, Glotz D, Lachmann N, Mohanakumar T, Suciu-Foca N, Sumitran-Holgersson S, Tanabe K, Taylor CJ, Tyan DB, Webster A, Zeevi A, Opelz G. Transplantation 2013 Jan 15;95(1):19-47.
    • Elevation of High-Mobility Group Box 1 after Clinical Autologous Islet Transplantation and Its Inverse Correlation with Outcomes. Itoh T, Iwahashi S, Kanak MA, Shimoda M, Takita M, Chujo D, Tamura Y, Rahman AM, Chung WY, Onaca N, Coates PT, Dennison AR, Naziruddin B, Levy MF, Matsumoto S. Cell Transplant 2012 Dec 4
    • Increased expression of the glucose-responsive gene RCAN1 causes hypoinsulinemia, B cell dysfunction and diabetes. Peiris H, Raghupathi R, Jessup CF, Zanin MP, Mohanasundaram D, Mackenzie KD, Chataway T, Clarke JN, Brealey J, Coates PT, Pritchard MA, Keating DJ Endocrinology 2012 Nov;153 (11):5212-21
    • Screening for colorectal cancer and advanced colorectal neoplasia in kidney transplant recipients: a cross-sectional prevalence and diagnostic accuracy study of faecal immunochemical testing for haemoglobin and colonoscopy Collins,M.G., Teo,E., Cole,S.R., Chan,C-Y, McDonald, S.P., Russ,G.R., Young,G.P., Bampton P.A., Coates P.T. BMJ 2012 Jul 25;345:e4657. doi: 10.1136/bmj.e4657
    • Non-human primate Dendritic cells. Jesudason S, Collins, MG, Rogers, NM, Kireta, S, Coates PT J Leuk Biol 2012:91:217-28
    • Early exposure of interferon-γ inhibits signal transducer and activator of transcription-6 signalling and nuclear factor κB activation in a short-term monocyte-derived dendritic cell culture promoting 'FAST' regulatory dendritic cells. Rojas-Canales D, Krishnan R, Jessup CF, Coates PT Clin Exp Immunol. 2012 Mar;167(3):447-58
    • Renal Dendritic Cells Adopt a Pro-Inflammatory Phenotype in Obstructive Uropathy to Activate T Cells, but Do Not Directly Contribute to Fibrosis. Snelgrove SL, Kausman JY, Lo C, Lo C, Ooi JD, Coates PT, Hickey MJ, Holdsworth SR, Kurts C, Engel DR, Kitching AR. Am J Pathol. 2012;180:91-103.
    • Amelioration of renal ischaemia-reperfusion injury by liposomal delivery curcumin to renal tubular epithelial and antigen presenting cells Rogers NM, Stephenson M, Kitching A, Horowitz J, Coates PT Br J Pharmacol 2012;166:194-209
    • KHA-CARI adaption of the KDIGO clinical practice guideline for the care of kidney transplant recipients Chadban S, Barraclough K, Campbell, S, Clark C, Coates PT, Cohney S, Cross N, Eris J, Henderson L, Howell M, Isbel N, Kannellis J, Kotwal S, Manley P, Masterson R, Mulley W, Murall K, O'Connell P, Pilmore H, Rogers N, Russ G, Walker R, Webster A, Wiggins K, Wong G, Wyburn K Nephrology 2012;17:204-14
    • Urinary tubular biomarkers as potential early predictors of renal allograft rejection. Ting YT, Coates PT, Walker RJ, McLellan AD Nephrology 2012;17:11-16
    • Ultrastructural analysis, zinc transporters and hormones expression in new world primate (Callithrix jacchus) and human pancreatic islets. Mohanasundaram, D, Drogemuller C, Brealey, J, Jessup, CF, Milner, C, Murgia, C, Lang CJ, Milton, A, Zalewski, PD, Russ, GR, Coates PT Gen Comp Endocrinol 2011 Nov 1;174(2):71-9
    • The Sphingolipid Rheostat: A Potential Target for Improving Pancreatic Islet Survival and Function. Jessup CF, Bonder CS, Pitson SM, Coates PT. Endocr Metab Immune Disord Drug Targets. 2011 Jun 22
    • Calcium supplements lower bone resorption after renal transplant Yu RW, Faull RJ, Coates PT, Coates PS "Clin Transplant 2011 August 21
    • Approaching the promise of operational tolerance in clinical transplantation. Bishop GA, Ierino FL, Sharland AF, Hall BM, Alexander SI, Sandrin MS, Coates PT, McCaughan GW. Transplantation. 2011 May 27;91(10):1065-1074
    • Incorporation of endothelial progenitor cells into mosaic pseudoislets Penko D, Mohanasundaram D, Sen S, Drogemuller C, Mee C, Bonder CS, Coates PT, Jessup CF. Islets. 2011 May 1;3(3):73-9.
    • Donor human leukocyte antigen specific antibodies predict development and define prognosis in transplant glomerulopathy Eng HS, Bennett G, Chang SH, Dent H, McDonald SP, Bardy P, Coghlan P, Russ GR, Coates PT. Hum Immunol. 2011 May;72(5):386-91.
    • Endothelial progenitor cells: novel biomarkers and promising cellular therapy for cardiovascular disease Sen S, McDonald SP, Coates PT, Bonder CS. Clin Sci (Lond). 2011 Apr;120(7):263-83. Review.
    • Curcumin induces maturation resistant dendritic cells that expand T reg cells in vitro and in vivo Rogers NM, Kireta S, Coates PT. Clin Exp Immunol. 2010 Dec;162(3):460-73.
    • Desensitization for renal transplantation: depletion of donor-specific anti-HLA antibodies, preservation of memory antibodies, and clinical risks. Rogers NM, Eng HS, Yu R, Kireta S, Tsiopelas E, Bennett GD, Brook NR, Gillis D, Russ GR, Coates PT. Transpl Int. 2011 Jan;24(1):21-9.
    • Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus. Hughes A, Jessup C, Drogemuller C, Mohanasundaram D, Milner C, Rojas D, Russ GR, Coates PT. Curr Diabetes Rev. 2010 Sep 1;6(5):274-84. Review
    • Calcific uremic arteriolopathy--the argument for hyperbaric oxygen and sodium thiosulfate.Rogers NM, Coates PT. Semin Dial. 2010 Jan;23(1):38-42.
    • Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Ting YT, Coates PT, Marti HP, Dunn AC, Parker RM, Pickering JW, Jack RW, Kemp RA, Walker RJ, McLellan AD. Transplantation. 2010 May 15;89(9):1071-8.
    • Propagation and characterisation of dendritic cells from G-CSF mobilised peripheral blood monocytes and stem cells in common marmoset monkeys. Prasad S, Kireta S, Leedham E, Russ GR, Coates PT. J Immunol Methods. 2010 Jan 31;352(1-2):59-70. Epub 2009 Nov 18.
    • Review article: Kidney dendritic cells: their role in homeostasis, inflammation and transplantation. Rogers NM, Matthews TJ, Kausman JY, Kitching AR, Coates PT. Nephrology (Carlton). 2009 Oct;14(7):625-35. Review. Erratum in: Nephrology (Carlton). 2009 Dec;14(8):769. Kitching, Richard A [corrected to Kitching, A Richard].
    • Hyperparathyroidism and vitamin D deficiency predispose to bone loss in renal transplant recipients. Lim WH, Coates PS, Russ GR, Coates PT. Transplantation. 2009 Sep 15;88(5):678-83.
    • Clinical significance of anti-HLA antibodies detected by Luminex: enhancing the interpretation of CDC-BXM and important post-transplantation monitoring tools. Eng HS, Bennett G, Bardy P, Coghlan P, Russ GR, Coates PT. Hum Immunol. 2009 Aug;70(8):595-9. Epub 2009 Jun 12.
    • Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates. Brady JL, Mannering SI, Kireta S, Coates PT, Proietto AI, Cowan PJ, D'Apice AJ, Lew AM. Immunol Cell Biol. 2009 Jul;87(5):413-8. Epub 2009 Feb 10
    • Immunophenotyping of interstitial infiltrate does not distinguish between BK virus nephropathy and acute cellular rejection. Rogers NM, Russ GR, Cooper J, Coates PT. Nephrology (Carlton). 2009 Feb;14(1):118-22. Epub 2009 Jan 8.
    • Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Proia RL, Vadas MA, Gamble JR. Blood. 2009 Feb 26;113(9):2108-17. Epub 2008 Dec 24.
    • Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. Li JY, Yong TY, Bennett G, Barbara JA, Coates PT. Nephrology (Carlton). 2008 Dec;13(8):755-7.
    • Eng HS, Bennett G, Tsiopelas E, Lake M, Humphreys I, Chang SH, Coates PT, Russ GR. Am J Transplant. 2008 Nov;8(11):2335-42. Epub 2008 Sep 8.
    • Parental donors in live-donor kidney transplantation associated with increased rejection rates and reduced glomerular filtration rates. Lim WH, Chang SH, Coates PT, McDonald SP. Transplantation. 2007 Oct 27;84(8):972-80.

  • Community Engagement

    Community Service from 2000 onwards

    • Guest Speaker: Rotary Club of Naracoorte, South Australia 2000
    • Television Postcards "The Queen Elizabeth Hospital" Renal Research Transplantation Tours
    • Guest Speaker: Tall Poppy Back to School Program 2004
    • Adelaide High School September 2004
    • St Andrews Primary School October 2004
    • Guest Speaker: Diabetes Australia "Pancreatic Islet Transplantation" June 2005/October 2005
    • Guest Speaker Tall Poppy Back to School Program 2005
    • Christies Beach High School June 2005
    • Underdale High School July 2005
    • Guest Speaker Diabetes Australia "Diabetes and Kidney Disease" August 2005
    • Guest Speaker Juvenile Diabetes Research Foundation - Walk for the Cure August 2006
    • Guest Speaker Rotary Club of Munno Para , November 2006
    • Television Transplant Hope - ABC TV Science (31/8/2006)
    • Guest Speaker Lions Club of Naracoorte , March 2007
    • Guest Speaker Rotary Club of Camberwell, Victoria May 2007
    • Guest Speaker Diabetes SA - New Treatments for Type-1 diabetes 2010, 2011
    • Radio ABC Illawarra 97.3 "Organ Transplantation from Deceased donors: consensus statement on eligibility and allocation protocols" 2011
    • Radio ABC Radio National Bush Telegraph "Organ Transplantation from Non-Heart beating donors" Oct 2011
    • Television Channel 7 Today-Tonight "Type-1 Diabetes Trial" Friday 21st June 2013
    • Television Channel 7 Today-Tonight "Zaidees Rainbow Foundation for Organ Donation Awareness- Port Adelaide versus Hawthorn - Round 16" Friday July 12th 2013
    • Television Channel 9 News August 2013 "SA First Paired Kidney Exchange" Tuesday 20th August 2013
    • Academy of Technology, Sciences and Engineering "Rebuilding the body cell by Cell - the promise of Cell Therapy" February 25th 2014
    • Print Media               Border Watch, Mt Gambier -4th June 2015 page 9
    • Print Media               “Playing the Transplant Waiting Game” Port Lincoln Times

      Print Media               http://www.adelaidenow.com.au/news/south-australia/adelaide-mum-pushes-australianfirst-surgery-for-her-child-at-the-womens-and-childrens-hospital/news-story/86382ed77c4cd282d609b5677451  August 5th 2015

      Radio                          AAP Newswire 18-5-2015

                                          Nova 91.9 radio news 18-5-2015

                                          Cruise AM radio news 18-5-2015

                                          Triple M FM radio news 18-5-2015

                                          ABC 891 radio news 18-5-2015

                                          Mix FM 102.3 radio news 18-5-2015

                                          ABC South East radio news 18-5-2015

                                          5AA radio news 18-5-2015

                                          HIT 107 radio news 18-5-2015

      Press Release         “More Kidney Donors” 18-5-2015

    • Television Channel 10 News 2016


  • Files

The information in this directory is provided to support the academic, administrative and business activities of the University of Adelaide. To facilitate these activities, entries in the University Phone Directory are not limited to University employees. The use of information provided here for any other purpose, including the sending of unsolicited commercial material via email or any other electronic format, is strictly prohibited. The University reserves the right to recover all costs incurred in the event of breach of this policy.

Entry last updated: Saturday, 18 Jul 2020

To link to this page, please use the following URL:  https://www.adelaide.edu.au/directory/patrick.coates