Mr Paul Drew

 Position Visiting Research Fellow
 Org Unit Surgical Specialties
 Email paul.drew@adelaide.edu.au
 Telephone +61 8 8222 4143
 Location Floor/Room 5 28 ,  RAH - Eleanor Harrald ,   Royal Adelaide Hospital
  • Research Interests

    Mass spectrometry imaging

    DNA Methylation

    Oesophageal cancer

    Prostate cancer

    Androgen receptor signalling

    My research focuses on unravelling the mechanisms which regulate cancer development and progression, particularly prostate, oesophageal and young onset colorectal cancers.  Specific interests include the role of androgen signalling within fibroblasts and cancer cells, the cross-talk between fibroblasts and adjoining cancer cells, and the role of DNA methylation.  My aim is to improve our understanding of the biology of these cancers, to discover more useful biomarkers for diagnosis, prognosis, and response to therapy to assist in the clinical management of patients with these common and lethal cancers, and to uncover potential new therapies.

     

    Current projects:

    (1)  To discover clinically relevant biomarkers and increase our understanding of cancer biology through matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) of cancer tissues.

    The primary aim is to spatially map molecular profiles of the stroma and cancer cells and identify profiles which associate with clinical parameters, such as survival, to discover clinically relevant and robust biomarkers.

    Secondary aims are (1) to characterise the heterogeneity within the stroma and cancer cells using MSI molecular profiles, and determine associations between regional variations in the MSI molecular profiles of stroma and the profiles of the adjoining cancer cells, and (2) to determine relationships between profiles and conventional parameters such as activation of the androgen receptor signalling pathway.

     

    (2)  To investigate the relationship between early onset colorectal cancer and type 2 diabetes in either the patient or a first degree relative.

    One aim is investigate the relationship between type 2 diabetes and DNA methylation in colon epithelial cells, both in humans and in mouse models of diabetes.

  • Research Funding

    2007 The Cancer Council SA Research Grant (453588): Barrett's oesophagus: insights from and into fundoplication and oesophagectomy. Jamieson GG, Drew PA, Devitt PG, Ruszkiewicz AR, Smith E, Liu J-F, Kelly JJ. $71,750.

    2007 RAH/IMVS Research Committee Project Grant: The expression of miRNAs in oesophageal disease. Jamieson GG, Devitt PG, Drew PA, Smith E, Kelly JJ, Thompson S. $19,720.

    2004-2006 NHMRC Project Grant (275504): Barrett's oesophagus and reflux oesophagitis: efficacy of medical vs surgical management. Watson DI, Drew PA, Ruszkiewicz A, Jamieson GG, Bianco-Miotto T, DJ Hussey. $500,250.

    2004 RAH/IMVS Research Committee Clinical Project Grant: Application for the purchase of a tissue microarrayer for the construction of tissue microarrays for use in studies into colorectal and oesophageal cancer. Jamieson GG, Ruskiewicz AR, Drew PA, Smith E. $10,000.

    2003-2007 US NIH Grant (CA 001833-03): Molecular epidemiology of Barrett's esophagus and cancer. Whiteman DC, Drew PA, Gotley D, Green AC, Hayward NK, Jamieson GG, Parsons PG, Pavey SJ, Purdie DM, Smithers BM, Watson DI, Webb PM. US$265,000 pa.

    2003 RAH/IMVS Research Committee Clinical Project Grant: Discovery of new genes important in Barrett's oesophagus and adenocarcinoma of the oesophagus by in vitro demethylation of cell and tissue cultures. Bianco-Miotto T, Jamieson GG, Watson DI, Smith E, Drew PA. $20,000.

    2002-2004 NHMRC Project Grant (207740): Ablative therapies for Barrett's oesophagus - evaluation of new clinical and experimental therapies. Watson DI, G.G. Jamieson GG, Tan L-W, Drew PA, Schoeman M. $300,000.

  • Publications

    Palethorpe HM, Drew PA, and Smith E

    Androgen Signaling in Esophageal Adenocarcinoma Cell Lines In Vitro

    Digestive Diseases and Sciences 62(12), 3402–3414, 2017

     

    Smith E, Palethorpe HM, Hayden AL, Young JP, Underwood TJ and Drew PA.

    Fibroblasts derived from oesophageal adenocarcinoma differ in DNA methylation profile from normal oesophageal fibroblasts.

    Sci Rep. 2017 Jun 13;7(1):3368.

     

    Wong S, Lidums I, Rosty C, Ruszkiewicz AR, Parry S, Tomita Y, Win AK, Vatandoust S, Townsend A, Patel D, Jenny Hardingham J, Roder D, Smith E, Drew PA, Marker J, Uylaki W, Hewett P, Worthley D, Symonds E, Young GP, Price TJ, Young JP.

    Findings in young adults at colonoscopy from a hospital service database audit

    BMC Gastroenterology, 17(1), 56-1-56-9, 2017

     

    Liu JF, Li YS, Drew PA and Zhang C.

    The effect of celecoxib on DNA methylation of CDH13, TFPI2, and FSTL1 in squamous cell carcinoma of the esophagus in vivo.

    Anti-Cancer Drugs 27(9), 848-853, 2016  

     

    Zhang K, Liu JF, Li HF, Feng Y and Drew PA

    The expression of tachykinin receptors in the human lower esophageal sphincter

    European Journal of Pharmacology 774, 144-149, 2016

     

    Smith E, Palethorpe HM, Ruszkiewicz AR, Edwards S, Leach DA, Underwood TJ, Need EF and Drew PA.

    Androgen receptor and androgen-responsive gene FKBP5 are independent prognostic indicators for esophageal adenocarcinoma

    Digestive Diseases and Sciences 61 (2) 433-443, 2016         

     

    Leach DA, Need EF, Toivanen R, Trotta AP, Palethorpe HM, Tamblyn DJ, Kopsaftis T, England GM, Smith E, Drew PA, Pinnock CB, Lee P, Holst J, Risbridger GP, Chopra S, DeFranco DB, Taylor RA and Buchanan G.

    Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome

    Oncotarget 30;6(18):16135-50, 2015

     

    Liu JF, Zhang J, Liu XB and Drew PA

    Investigation of cholecystokinin receptors in the human lower esophageal sphincter

    World Journal of Gastroenterology 20(21), 6554 - 6559, 2014

     

    Smith E, Ruszkiewicz AR, Jamieson GG and Drew PA

    IGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation

    British Journal of Cancer 110, 775 - 782, 2013

     

    Attema JL, Bert AG, Lim YY, Kolesnikoff N, Lawrence D, Pillman KA, Smith E, Drew PA, Khew-Goodall Y, Shannon MF and Goodall GJ.

    Identification of an enhancer that increases miR-200b~200a~429 gene expression in breast cancer cells

    PLoS ONE 8(9): e75517.

     

    YY Lim, JA Wright, JL Attema, PA Gregory, AG Bert, E Smith, D Thomas, PA Drew, Y Khew-Goodall and GJ Goodall

    Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state. 

    Journal of Cell Science  126, 2256 - 2266, 2013

     

    Liu J.F., Sun J. and Drew P.A.

    Characterization of excitatory and inhibitory motor neurons to the human gastric clasp and sling fibers

    Canadian Journal of Physiology and Pharmacology  89, 617 - 22, 2011

     

    Nancarrow D.J., Andrew D. Clouston A.D., Smithers B.M., Gotley D.C., Drew P.A., Watson D.I., Tyagi S., Hayward N.K and Whiteman D.C.

    Whole genome expression array profiling highlights differences in mucosal defense genes in Barrett’s esophagus and esophageal adenocarcinoma

     PLoS ONE  6(7), e22513, 2011.

     

    Gregory P.A., Bracken C.P., Smith E., Bert A.G., Wright J.A., Roslan S., Morris M., Wyatt L., Farshid G., Lindeman G., Shannon M.F., Drew P.A., Khew-Goodall Y.  and Goodall G.J.

    An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.

    Molecular Biology of the Cell  22, 1686 - 98, 2011.

     

    Zhishan Wang, Yong Zhao, Eric Smith, Gregory J. Goodall, Paul A. Drew, Thomas Brabletz, Chengfeng Yang

    Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by micoRNA-200b

    Toxicological Sciences  121, 110 - 22, 2011.

     

    Underwood T.J., Derouet M.F., White M.J., Noble F., Moutasim K.A., Smith E., Drew P.A., Thomas G.J., Primrose J.N. and Blaydes J.P.

    A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture.

    Biology of the Cell  102, 635 - 44, 2010.

     

    Abu-sneineh A., Tam W., Schoeman M., Fraser R., Andrew Ruszkiewicz A.R., Smith E., Drew P.A., Dent J., and Holloway R.H.

    Effect of high-dose esomeprazole on gastric and esophageal acid exposure and molecular markers in Barrett’s esophagus.

    Alimentary Pharmacology and Therapeutics  32, 1023 - 30, 2010

     

    Antonsson A, Nancarrow D.J., Brown  I.S., Green A.C., Drew P.A., Watson D.I., Hayward N.K.,  and Whiteman D.C.

    High-risk human papillomavirus in esophageal squamous cell carcinoma.

    Cancer Epidemiology, Biomarkers, & Prevention  19, 2080 - 7, 2010

     

    Smith E., Kelly J.J., Ruskiewicz A.R., Sullivan T., Jamieson G.G. and Drew P.A.

    The effect of long-term control of reflux by fundoplication on aberrant deoxyribonucleic acid methylation in patients with Barrett esophagus.

    Annals of Surgery  252, 63 - 9, 2010.

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Entry last updated: Thursday, 14 Dec 2017

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