Dr Andrea Yool
|Position||Professor and Head of Physiology|
|Org Unit||Medical Sciences|
|Telephone||+61 8 8313 3359|
Medical School North
HLTH SCI 1005. Principles of Human Health and Disease *
This new first-year elective course will start in semester 2, 2016.
PHYSIOL 2510. Physiology IIA: Heart, Lung & Neuromuscular Systems
PHYSIOL 2520. Physiology IIB: Systems & Homeostasis
PHYSIOL 3001. Cellular & Systems Neurobiology
PHYSIOL 3000. Integrative and Applied Systems Physiology
ANAT SC 3102. Integrative and Comparative Neuroanatomy III
DENT 1005AHO. Dental Science and Practice I part 1
BIOL 1310A. Fundamentals of Biomedical Science
PHYSIOL 4000. Honours
-- for more information, see Course Outlines --
* Principles of Human Health and Disease takes a case-based approach to exploring the science underpinning human health and disease. Lectures are clustered into six themes. Each fortnightly theme starts with a case-study description of human clinical symptoms, and builds an integrated interdisciplinary view of the relevant anatomy, physiology, pharmacology and pathology involved in the case. Themes will be selected each year from current topics including hypertension, cancer, cardiovascular disease, degenerative disease, reproductive and developmental disorders and others. Prerequisite: 3 units of biology. Assumed knowledge: High school chemistry.
Honours and PhD projects
Targeting pharmacological agents to mammalian aquaporins offers new methods for treating brain injury, stroke, cancer, gastrointestinal, kidney and other diseases. The Aquaporin Physiology & Drug Discovery laboratory provides opportunities for Honours and PhD projects that are focused on drug discovery for classes of mammalian aquaporins (AQPs). The main area of current research is the AQPs that are upregulated in cancer cells, and linked to the acceleration of cell migration. AQP1 upregulation is diagnostic of aggressive cancers such as glioblastoma, breast and colon; the AQP1 channel is localised at the leading edges of the cells and essential for motility. Selective pharmacological modulators developed by our group are being used to evaluate the dependence of migration on AQP1 water and cation channel activity in cancer and stem cell lines. Weekly lab group journal clubs provide training in critical evaluation skills, and breadth in the relevant scientific literature.
Honours and PhD thesis projects are customised to fit with areas of interest for students. Methods including cell culture, imaging, molecular biology, electrophysiology, or immunocytochemistry techniques can be focused on: (1) discovery of new aquaporin agonists and antagonists; (2) molecular definition of the structures of permeation pathways; (3) identification of drug docking sites; and (4) quantification of migration rates in cancer cell lines, to assess effects of AQP modulators. New agents targeting migration and metastasis could be of substantial value in cancer therapy and other diseases.
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Entry last updated: Wednesday, 16 Aug 2017
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