Professor Karen Jones

Professor Karen Jones
 Position William T Southcott Research Fellow
 Org Unit Medical Specialties
 Email karen.jones@adelaide.edu.au
 Telephone +61 8 8313 7821
 Location Floor/Room WS5067.01 ,  Adelaide Health and Medical Sciences ,   North Terrace
  • Biography/ Background

    Prof Jones is a career researcher with a background in medical imaging. She was the first nuclear medicine technologist to be awarded a PhD in Australia. Her research activities have capitalised on the development of state-of-the-art imaging techniques to evaluate gastric motor function and blood flow; this development has been facilitated by the involvement of a number of international collaborators. Her research area is in the under-recognised field of postprandial hypotension, a substantial fall in blood pressure that occurs within 2 hours of a meal, which is frequently seen in older people and patients with type 2 diabetes. She has had an ongoing involvement with the pharmaceutical industry and she has been responsible for several investigator-initiated trials. Prof Jones was the top nuclear medicine student in her graduating year at the University of South Australia and has been the recipient of several awards including the ANSTO award for nuclear medicine scientists, Hanson Institute New Investigator award for clinical research and a prestigious NHMRC Achievement Award. Prof Jones has supervised 13 honours, 10 PhD, and 4 Masters students to completion and is a supervisor of 5 current students (2 Honours, 3 PhD). She is an author of 180 original papers, 49 reviews, 9 letters and 10 book chapters. She has an h-index of 63 and her work has been cited >12,000 times (Google Scholar).

  • Awards & Achievements

    1991: Awarded prize for top Nuclear Medicine student, University of South Australia

    1991: Awarded prize for top Nuclear Medicine student in SA, ANZSNM (SA Branch)

    1999: Recipient of the Australian Nuclear Science and Technology Organisation (ANSTO) Award

    1999: Recipient of the Abbott Laboratories/Roche Products GESA Travel Award

    2002: Recipient of a Juvenile Diabetes Foundation of Australia Travel Award

    2003: Recipient of an NHMRC/Diabetes Australia Career Development Award

    2003: Recipient of the Hanson Institute New Investigator Award for Clinical Research

    2008: Promotion to Associate Professor

    2010: Recipient of an NHMRC Senior Clinical Career Development Award

    2010: Recipient of an NHMRC Achievement Award

    2011: Promotion to Professor

     

  • Research Funding

    Previous funding:

    Prof Jones has previously held grants totalling >$20,000,000 comprising 16 funded NHMRC project grants (2 as CIA: NHMRC ID: APP453650 and NHMRC ID: APP627189), an NHMRC/Diabetes Australia Career Development Award (CDA) (NHMRC ID: APP250453), an NHMRC Senior CDA (NHMRC ID: APP627011), an NHMRC CCRE in Nutritional Physiology, Interventions and Outcomes (NHMRC ID: APP453557) and numerous other grants e.g. from the Diabetes Australia Research Trust (DART), Royal Adelaide Hospital (RAH) Research Committee, The Rebecca Cooper Medical Foundation, The Vera Ramaciotti Research Foundation, The University of Adelaide and UniSA.

    Currently held:

    2018 – 2020: T Wu, C Rayner, KL Jones - NHMRC Project Grant: APP1147333 - Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in health and type 2 diabetes. ($725,276)

    2018 – 2020: M Chapman, A Deane, S Soenen, L van Loon, KL Jones - NHMRC Project Grant: APP1144496 - Project title: Protein absorption and kinetics in critical illness. ($1.2M)

    2018-2019: KL Jones, C Rayner, T Wu, D Bartholomeusz, M Horowitz, S Veedfald, JJ Holst, M Rosenkilde, C Deacon; - Royal Adelaide Hospital Research Foundation - Clinical Project Grant - Project title: Role of endogenous glucose-dependent insulinotropic polypeptide (GIP) in the gastric emptying, glycaemia, splanchnic blood flow and blood pressure responses to oral glucose in healthy older subjects. ($49,472)

    2019-2021: C Rayner, J Holst- NHMRC Project Grant: APP1163910 - Project title: GIP actions in health and disease – human studies using a novel GIP antagonist. ($1,535,788) Role: Associate Investigator

    2019: KL Jones, L Phillips, T Wu, C Marathe, M Horowitz, C Rayner – Diabetes Australia Research Trust General Grant - Project title: Effect of exenatide once weekly on gastric emptying of, and the postprandial glycaemic and cardiovascular responses to, an oral glucose load in type 2 diabetes($59,872)

    2019: T Wu, C Rayner, KL Jones, M Horowitz – Diabetes Australia Research Trust General Grant - Project title: Role of bile acids in glucose lowering by metformin.($59,991)

    2019: KL Jones, L Phillips, C Rayner, T Wu, M Horowitz - Royal Adelaide Hospital Research Foundation - Clinical Project Grant - Project title: Effect of exenatide BID on small intestinal transit, absorption, glycaemia and blood pressure in type 2 diabetes. ($49,859)

    2019: L Phillips, C Rayner, T Wu, KL Jones, M Horowitz - Royal Adelaide Hospital Research Foundation - Clinical Project Grant - Project title: Effects of acute and sub-acute treatment with metformin on cardiovascular responses to a glucose challenge in type 2 diabetes.($49,998)

    2019: M Horowitz, KL Jones, A Deane, C Marathe, M Nauck – Royal Adelaide Hospital Research Foundation Near Miss Grant - Project title: Effect of GLP-1RAs on glycaemic control in type 2 diabetes. ($49,950)

     

  • Publications

    PUBLICATIONS LAST 5 YEARS - FROM 2014

     

    ORIGINAL PAPERS

    1.  Stevens JE, Buttfield MDM, Wu T, Hatzinikolas S, Pham HT, Lange K, Rayner CK, Horowitz MJones KLEffects of sitagliptin on gastric emptying of, and the glycaemic and blood pressure responses to, a carbohydrate meal in type 2 diabetes.Diabetes Obes Metab (accepted for publication 25 August 2019)

     

    2. Riceman MD, Bound M, Grivell J, Hatzinikolas S, Piotto S, Nguyen NQ, Jones KL, Horowitz M, Rayner CK, Phillips LK. The prevalence and impact of low fecal elastase-1 in community-based patients with type 2 diabetes. Diabetes Res Clin Pract (accepted for publication 20 August 2019)

     

    3. Pham H, Trahair LG, Phillips LK, Rayner CK, Horowitz M, Jones KL. A randomised crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure response in healthy adults. BMC Geriatr (accepted for publication 17 August 2019)

     

    4. Pham H, Phillips L, Trahair LG, Hatzinikolas S, Horowitz M, Jones KL. Longitudinal changes in the blood pressure responses to, and gastric emptying of, an oral glucose load in healthy older subjects. J Gerontol A Biol Sci Med Sci 2019 [epub ahead of print]

     

    5. Pham H, Marathe CS, Phillips LK, Trahair LG, Hatzinikolas S, Huynh L, Wu T, Nauck MA, Rayner CK, Horowitz M, Jones KL. Longitudinal changes in fasting and glucose-stimulated GLP-1 and GIP and GLP-1 in healthy older subjects. J Clin Endocrinol Metab 2019 [epub ahead of print]

     

    6. Watson LE, Phillips LK, Wu T, Bound MJ, Checklin H, Grivell J, Jones KL, Clifton P, Horowitz M, Rayner CK. A whey guar “preload” improves postprandial glycemia and HbA1c in type 2 diabetes – a 12-week, single-blind, randomised and placebo controlled trial. Diabetes Obes Metab 2019 [epub ahead of print]

     

    7. Watson LE, Phillips LK, Wu T, Bound MJ, Jones KL, Horowitz M, Rayner CK. Longitudinal evaluation of gastric emptying in type 2 diabetes. Diabetes Res Clin Pract 2019;154:27-34.

     

    8. Watson LE, Xie C, Wang X, Li Z, Phillips LK, Sun Z, Jones KL, Horowitz M, Rayner CK, Wu T. Gastric emptying in patients with well-controlled type 2 diabetes compared to healthy young and older individuals. J Clin Endocrinol Metab 2019;104:3311-9.

     

    9.  Zhang X, Young RL, Bound M, Hu S, Jones KL, Horowitz M, Rayner CK, Wu T. Comparative effects of proximal and distal small intestinal glucose exposure on glycaemia, incretin hormone secretion and the incretin effect in health and type2 diabetes. Diabetes Care 2019;42:520-8.

     

    10.  Jones KL, Rigda RS, Buttfield MDM, Hatzinikolas S, Pham HT, Marathe CS, Wu T, Lange K, Trahair LG, Rayner CK, Horowitz M. Effects of lixisenatide on postprandial blood pressure, gastric emptying and glycemia in health and type 2 diabetes. Diabetes Obes Metab 2019;21:1158-67.

     

    11. Kar P, Plummer MP, Abdelhamid YA, Giersch EJ, Summers MJ, Weinal L, Finnis ME, Phillips LK, Jones KL, Horowitz M, Deane AM. Incident diabetes in survivors of critical illness and mechanisms underlying chronic glucose intolerance: a prospective cohort study. Crit Care Med 2019;47:e103-11.

     

    12. Borg M, Bound MJ, Grivell J, Sun Z, Jones KL, Horowitz M, Rayner CK, Wu T. Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and glucagon-like peptide-1, and gastric emptying after oral glucose, in type 2 diabetes. Diabetes Obes Metab 2019;21:640-7.

     

    13. Borg M, Bound MJ, Grivell J, Sun Z, Rayner CK, Horowitz M, Jones KL, Wu T. Metformin attenuates the fall in postprandial blood pressure and slows gastric emptying in type 2 diabetes. Diabetes Obes Metab 2019;21:1251-4.

     

    14. Marathe CS, Rayner CK, Jones KL, Horowitz M. Impact of variations in duodenal glucose load on insulin clearance in health and type 2 diabetes. Acta Diabetol 2018;55:205-7.

     

    15. Nguyen TAN, Abdelhamid YA, Hatzinikolas S, Kar P, Summers MJ, Phillips LK,Horowitz M, Jones KL,Deane AM. Postprandial hypotension in older survivors of critical illness. J Crit Care 2018:45:20-6.

     

    16. Trahair LG, Wu T, Feinle-Bisset C, Marathe CS, Rayner CK, Horowitz M, Jones KL. Comparative effects of small intestinal glucose on blood pressure, heart rate and noradrenaline responses in obese, and healthy, subjects. Physiol Rep 2018;6:4.

     

    17. Giezenaar C, van der Burgh Y, Lange K, Hatzinikolas S, Hausken T, Jones KL, Horowitz M, Chapman IC, Soenen S. Effects of substitution, and adding of carbohydrates and fat to whey-protein or on energy intake, appetite, gastric emptying, glucose, insulin, ghrelin, CCK and GLP-1 in healthy older men. Nutrients 2018;10:E113.

     

    18. Du Y, Piscitelli D, Ahmad S, Greenfield JR, Somacho-Bonet D, Rayner CK, Horowitz M, Jones KL. A randomised crossover study of the effects of glutamine on the rate of gastric emptying of low- and high-nutrient liquids in healthy young subjects. Nutrients 2018;10:739.

     

    19. Pham HT, Stevens JE, Rigda RS, Phillips LK, Wu T, Hausken T, Soenen S, Visvanathan R, Rayner CK, Horowitz M, Jones KL. Effects of the artificial sweetener, sucralose, on blood pressure, heart rate and superior mesenteric artery blood flow in healthy older subjects. Am J Clin Nutr2018;108:156-62.

     

    20. Giezenaar C, Hutchison AT, Luscombe-Marsh ND, Hausken T, Jones KL, Lange K, Horowitz M, Chapman IC, Soenen S. Effect of gender on the acute effects of whey protein intake on energy intake, appetite, gastric emptying and gut hormone responses in healthy young adults. Nutr Diabetes 2018;8:40.

     

    21.  Rigda RS, Trahair LG, Wu T, Little TJ, Lange K, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Effects of length and region of small intestinal glucose exposure on blood pressure, superior mesenteric artery blood flow and plasma noradrenaline in healthy older participants. J Aging Res Clin Pract 2018;7:149-55.

     

    22. Giezenaar C, Lange K, Hausken T, Jones KL, Horowitz M, Chapman IC, Soenen S. Acute effects of substitution, and addition, of carbohydrates and fat to protein on gastric emptying, blood glucose, gut hormones, appetite, and energy intake. Nutrients2018;7:10.

     

    23. Watson LE, Phillips LK, Wu T, Bound MJ, Checklin H, Grivell JM, Jones KL, Horowitz M, Rayner CK. Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clin Nutr 2018;pii:S0261-5614(18)32582-2.

     

    24. Marathe CS, Rayner CK, Jones KL, Horowitz M. Reactive hypoglycaemia with seizure following intraduodenal glucose infusion in a patient with type 2 diabetes. Acta Diabetol 2017;54:215-8.

     

    25. Kar P, Jones KL, Plummer MP, Abdelhamid YA, Giersch EJ, Summers MJ, Hatzinikolas S, Heller S, Horowitz M, Deane AM. Antecedent hypoglycemia does not attenuate the acceleration of gastric emptying by hypoglycaemia. J Clin Endocrinol Metab 2017;102:3953-60.

     

    26.  Wu T, Rayner CK, Jones KL, Horowitz M, Little TJ. Comparative effects of intraduodenal fat and glucose on the gut-incretin axis in healthy males. Peptides 2017;95:124-7.

     

    27. Giezenaar C, Trahair LG, Luscombe-Marsh ND, Hausken T, Standfield S, Jones KL, Horowitz M, Chapman I, Soenen S. Effects of randomized whey protein preloads on energy intake, appetite, gastric emptying and plasma gut hormone concentrations in older men and women. Am J Clin Nutr 2017;106:865-77.

     

    28. Trahair LG, Rajendran S, Visvanathan R, Chapman M, Stadler D, Horowitz M, Jones KL. Comparative effects of glucose and water drinks on blood pressure and cardiac function in older subjects with and without postprandial hypotension. Physiol Rep 2017;5:e13341.

     

    29.  Wu T, Trahair LG, Little TJ, Bound MJ, Zhang X, Wu H, Sun Z, Horowitz M, Rayner CK, Jones KL. Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes. Diabetes Care 2017;40:702-5.

     

    30. Marathe CS, Rayner CK, Lange K, Bound M, Wishart J, Jones KL, Kahn SE, Horowitz M. Relationships of the early insulin secretory response and oral disposition index with gastric emptying in subjects with normal glucose tolerance. Physiol Rep 2017;5:e13122.

     

    31. Wu T, Xie C, Wu H, Jones KL, Horowitz M, Rayner CK. Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes. Diabetes Obes Metab 2017;19:290-3.

     

    32. Trahair LG, Marathe CM, Standfield S, Rayner CK, Feinle-Bisset C, Horowitz M, Jones KL. Effects of small intestinal glucose on glycaemia, insulinaemia and incretin hormone release are load-dependent in obese subjects. Int J Obes 2017;41:225-32.

     

    33. Thazhath SS, Marathe CS, Wu T, Chang J, Khoo J, Kuo P, Checklin HL, Bound MJ, Rigda RS, Horowitz M, Jones KL, Rayner CK. Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes. Diab Vasc Dis Res 2017;14:59-63.

     

    34. Wu T, Zhang X, Trahair LG, Bound MJ, Little TJ, Deacon CF, Horowitz M, Jones KL, Rayner CK. Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes. J Clin Endocinol Metab 2016;101:4769-4778.

     

    35. Rigda R, Trahair LG, Little T, Wu T, Standfied S, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects. Peptides 2016; 86:126-32.

     

    36.  Kar P, Plummer MP, Bellomo R, Jenkins AJ, Januszewski AS, Chapman MJ, Jones KL, Horowitz M, Deane AM. Liberal glycemic control in critically ill patients with type-2 diabetes: an exploratory study Crit Care Med 2016;44:1695-703.

     

    37. Plummer MP, Kar P, Cousins C, Hausken T, Lange K, Chapman M, Jones KL, Horowitz M, Deane AM. Critical illness is associated with impaired gallbladder emptying as assessed by 3D ultrasound. Crit Care Med 2016;44:e790-6.

     

    38. Kar P, Plummer MP, Chapman MJ, Cousins CE, Lange K, HorowitzM, JonesKL, Deane AM. Energy-dense formulae may slow gastric emptying in the critically ill. J Parenter Enteral Nutr. 2016;40:1050-6.

     

    39. Trahair LG, Kimber TE, Flabouris K, Horowitz M, Jones KL. Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson’s disease. World J Gastroenterol 2016;22:4860-7.

     

    40.  Marathe CS, Horowitz M, Trahair LG, Bound M, Checklin H, Lange K, Rayner CK, Jones KL. Effect of duodenal glucose load on blood pressure in type 2 diabetes. Diabetes Res Clin Pract 2016;113:38-40.

     

    41. Wu T, Little TJ, Bound MJ, Borg M, Zhang X, Deacon CF, Horowitz M, Jones KL, Rayner CK. A protein preload enhances the glucose-lowering efficacy of vildagliptin in type 2 diabetes. Diabetes Care. 2016;39:511-7.

     

    42.  Thazhath SS, Bound MJ, Checklin H, Standfield S, Jones KL, Horowitz M, Rayner CK. Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes - a randomised controlled trial. Nutrition 2016;32:553-9.

     

    43. Thazhath SS, Bound MJ, Checklin H, Standfield S, Jones KL, Horowitz M, Rayner CK. Administration of resveratrol for five weeks has no effect on GLP-1 secretion, gastric emptying, or glycemic control in type 2 diabetes - a randomised controlled trial. Am J Clin Nutrit 2016;103:66-70. 

     

    44. Thazhath SS, Wu T, Chang J, Khoo J, Kuo P, Checklin H, Bound MJ, Rigda R, Crouch B, Jones KL, Horowitz M, Rayner CK. The glucagon-like peptide-1 (GLP-1) receptor agonist, exenatide, inhibits small intestinal motility, flow, transit and absorption of glucose in healthy subjects and patients with type 2 diabetes: a randomised controlled trial. Diabetes 2016;65:269-75.

     

    45. Hutchison AT, Piscitelli D, Horowitz M, Jones KL, Clifton PM, Standfield S, Hausken T, Feinle-Bisset C, Luscombe-Marsh N. Acute load-dependent effects of oral whey protein on gastric emptying, gut hormone release, glycemia, appetite, and energy intake in healthy men.  Am J Clin Nutr 2015;102:1-11.

     

    46. Giezenaar C, Trahair LG, Rigda RS, Hutchison AT, Feinle-BissetC, Luscombe-Marsh ND, Hausken T, JonesKL, HorowitzM, Chapman IM, Soenen S. Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls. 2015; Am J Physiol Regul Integr Comp Physiol.  2015;309:R845-54.

     

    47. Marathe CS, Horowitz M, Trahair LG, Wishart JM, Bound M, Lange K, Rayner CK, Jones KL. Relationships of 'Early' And 'Late' Glycemic Responses With Gastric Emptying During An Oral Glucose Tolerance Test. J Clin Endocrinol Metab 2015;100:3565-71.

     

    48. Marathe CS, Feinle-Bisset C, Pilichiewiczs A, Lange K, Jones KL, Rayner CK, Kahn SE, Horowitz M. The duodenal glucose load impacts the oral disposition index in healthy subjects. Diabet Med 2015;32:1500-3.

     

    49. Trahair LG, Horowitz M, Jones KL. Postprandial hypotension is associated with more rapid gastric emptying in healthy older individuals. J Am Med Dir Assoc 2015;16:521-3.

     

    50. Marathe CS, Bound M, Lange K, Jones KL, Rayner CK, Horowitz M. Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health. Acta Diabetol 2015;63:2668-75.

     

    51. Wu T, Thazhath SS, Marathe CS, Bound MJ, JonesKL, HorowitzM, Rayner CK. Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutr Diabetes. 2015;8:5:e156.

     

    52. Trahair LG, Horowitz M, Stevens JE, Feinle-Bisset C, Standfield S, Piscitelli D, Rayner CK, Deane AM, JonesKL. Effects of exogenous glucagon-like peptide-1 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral glucose in older individuals with normal glucose tolerance or type 2 diabetes. Diabetologia 2015;58:1769-78.

     

    53. Plummer M, Jones KL, Trahair L, Meier JJ, Chapman M, Horowitz M, Deane A.  Hyperglycemia potentiates the slowing of gastric emptying induced by exogenous GLP-1. Diabetes Care 2015;38:1123-9.

     

    54.  Ma J, Jesudason D, Stevens J, Jones KL, Clifton P, Horowitz M, Rayner CK.  Sustained effects of a protein ‘preload' on glycaemia and gastric emptying over 4 weeks in patients with type 2 diabetes: a randomized clinical trial. Diabetes Res Clin Pract 2015;108:E31-4.

     

    55. Kar P, Cousins CE, Annink CE, Jones KL, Chapman MJ, Meier JJ, Nauck M, Horowitz M, Deane AM.  Effects of glucose-dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study.  Crit Care 2015;19:20.

     

    56. Wu T, Trahair LG, Bound MJ, Deacon CF, Horowitz M, Rayner CK, Jones KL. Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide? Diabet Med 2015;32:595-600.

     

    57. Wu T, Ma J, Bound MJ, Checklin H, Deacon CF, Jones KL, Horowitz M, Rayner CK.  Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans, and patients with type 2 diabetes treated with or without metformin. Diabetes 2014;63:2776-87.

     

    58. Plummer M, Jones KL, Annink C, Cousins C, Meier J, Chapman M, Horowitz M, Deane M. Glucagon-like peptide-1 attenuates the acceleration of gastric emptying induced by hypoglycaemia in health subjects. Diabetes Care 2014;37:1509-15.

     

    59. Marathe CS, Rayner CK, Bound M, Checklin H, Standfield S, Wishart J, Lange K, Jones KL, Horowitz M.  Small intestinal glucose exposure determines the magnitude of the incretin effect in health and type 2 diabetes. Diabetes 2014;63:2668-75.

     

    60. Thazhath S, Wu T, Bound M, Checklin H, Jones KL, Willoughby S, Horowitz M, Rayner CK.  Changes in meal composition and duration affect postprandial endothelial function in healthy humans. Am J Physiol Gastrointest Liver Physiol 2014;307:G1191-7.

     

    61. Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL. Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance. Physiol Rep 2014;2:e12204-10.

     

    62.  Wu T, Thazhath S, Bound M, Jones KL, Horowitz M, Rayner CK.  Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?  Diabetes Res Clin Pract 2014; 106:e3-6.

     

    63. Trahair LG, Horowitz M, Hausken T, Feinle-Bisset C, Rayner CK, Jones KL. Effects of exogenous glucagon-like-peptide-1 on the blood pressure, heart rate, mesenteric blood flow and glycemic responses to intraduodenal glucose in healthy older subjects. J Clin Endocrinol Metab 2014;99:E2628-34.

     

    64. Umapathysivam MM, Lee MY, Jones KL, Annink CE, Cousins CE, Trahair LG, Rayner CK, Chapman MJ, Nauck MA, Horowitz M, Deane AM. Comparative effects of prolonged and intermittent stimulation of the glucagon-like peptide 1 receptor on gastric emptying and glycemia. Diabetes 2014;63:785-90.

     

    REVIEWS/EDITORIALS

    65. Pham H, Phillips LK, Jones KL. Acute effects of nutritive and non-nutritive sweeteners on postprandial blood pressure. Nutrients 2019;11:8.

     

    66. Marathe CS, Marathe J, Rayner CK, Kar P, Jones KL, Horowitz M. Hypoglycaemia and gastric emptying. Diabetes Obes Metab 2019;21:491-8.

     

    67. Camilleri M, Chedid V, Ford A, Haruma K, Horowitz M, Jones KL, Low PA, Park S-Y, Parkman H, Stanghellini V. Gastroparesis. Nat Rev Dis Primers 2018;4:41.

     

    68. Marathe CS, Rayner CK, Wu T, Jones KL, Horowitz M. Gastric emptying and the personalized management of type 1 diabetes. J Clin Endocrinol Metab 2018;103:3503-6.

     

    69. Du Y, Rayner CK, Jones KL, Talley N, Horowitz M. Gastrointestinal symptoms in diabetes – prevalence, assessment, pathogenesis and management. Diabetes Care 2018;41:627-37.

     

    70. Wu T, Rayner CK, Marathe CS, Jones KL, Horowitz M. Glucagon receptor signalling - backwards and forwards.  Expert Opin Investig Drugs 2018;27:135-138.

     

    71. Rayner CK, Jones KL, Wu T, Horowitz M. Gut feelings about diabetes and GLP-1 receptor agonists – lessons to be learnt from studies in functional gastrointestinal disorders. Diabetes Obes Metab 2017;19:309-12.

     

    72. Nguyen TA, Abdelhamid YA, Phillips LK, Chapple LS, Horowitz M, Jones KL, Deane AM. Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients. World J Crit Care Med 2017;6:28-36.

     

    73. Horowitz M, Wu T, Deane AM, Jones KL, Rayner CK. Dipeptidyl peptidase 4 inhibition and the known unknown. Diabetes 2016;65:1-3.

     

    74. Marathe CS, Rayner CK, Jones KL, Horowitz M. Novel insights into the effects of diabetes on gastric motility. Expert Rev Gastroenterol Hepatol 2016;10:581-93.

     

    75. Soenen S, Rayner CK, Jones KL, Horowitz M. The ageing gastrointestinal tract. Curr Opin Clin Nutr Metab Care2016;19:12-8.

     

    76. Soenen S, Rayner CK, Horowitz M, Jones KL. Gastric emptying in the elderly. Clin Geriatr Med 2015;31:339-53.

     

    77. Kar P, Jones KL, Horowitz M, Deane AM. Management of critically ill patients with type 2 diabetes: the need for personalised therapy. World J Diabetes 2015;6:693-706.

     

    78. Kar P, Jones KL, Horowitz M, Chapman MJ, Deane AM. Measurement of gastric emptying in the critically ill.  Clin Nutr 2015;34:557-64.

     

    79. Phillips LK, Rayner CK, Deane A, Jones KL, Horowitz M. Gastric emptying and glycaemia in health and diabetes mellitus. Nat Rev Endocrinol 2015;11:112-28.

     

    80. Phillips L, Rayner CK, Jones KL, Horowitz M. Measurement of gastric emptying in diabetes.  J Diabetes Complicat 2014;28:894-903.

     

    81. Rayner CK, Ma J, Jones KL, Clifton PM, Horowitz M. Protein ‘pre-loads’ in type 2 diabetes: what do we know and what do we need to find out?  Diabetologia 2014;57:2603-4.

     

    82. Trahair LG, Horowitz M, Jones KL.  Postprandial hypotension: a systematic review. J Am Med Dir Assoc 2014;15:394-409.

     

    LETTERS

    83. Rayner CK, Jones KL, Horowitz M. Is making the stomach pump better the answer to gastroparesis? Gastroenterology 2019;156:1555-7.

     

    84. Wu T, Marathe CS, Horowitz M, Jones KL, Rayner CK. Will faster-acting mealtime insulin work better for control of postprandial glycemia? Diabetes Care 2018;41:e27-8.

     

    85. Marathe CS, Rayner CKJones KL,Horowitz M. Gastrointestinal motility in people with type 1 diabetes and peripheral neuropathy. Diabetologia 2017;60:2312-3.

     

    86. Marathe CS, Rayner CK, Jones KL, Horowitz M. Reactive hypoglycaemia with seizure following intraduodenal glucose infusion in a patient with type 2 diabetes. Acta Diabetol 2017;54:215-8.

     

    87. Marathe CS, Rayner CK, Jones KL, Horowitz M. Letter to the Editor: One-hour postload hyperglycaemia is a strong predictor of type 2 diabetes than impaired fasting glucose. J Clin Endocrinol Metab 2016;101:L33-4.

     

    BOOK CHAPTERS

    88. Rayner CK, Jones KL, Horowitz M.  Diabetes and the gut.  Handbook of gastrointestinal motility and functional disorders.  Rao SSC, Parkman HP, McCallum RW, eds. 2015, pp 283-94.

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Entry last updated: Wednesday, 2 Oct 2019

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