Associate Professor Lyndsey Collins-Praino

Associate Professor Lyndsey Collins-Praino
 Position Associate Professor
 Org Unit Medical Sciences
 Telephone +61 8 8313 5488
 Location Floor/Room N2 12 ,  Helen Mayo North ,   North Terrace
  • Biography/ Background

    Dr Lyndsey Collins-Praino holds a PhD in behavioral neuroscience.  Her research focuses on the pathophysiological mechanisms underlying cognitive decline in healthy aging and in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. She is particularly interested in the role of inflammation in this process. Her research has appeared in a variety of high-quality, peer-reviewed journals, and she has presented it at both national and international conferences. Lyndsey is the recipient of numerous prestigious fellowships, honours and awards for the novelty, quality and interest of this work.

    In addition to her research background, Lyndsey has significant teaching experience. She is co-convenor of the Neuroscience major in the Bachelor of Health and Medical Sciences, and teaches neuroanatomy and neuroscience courses to nursing, medical and health sciences students. She is also heavily involved in neuroscience outreach in the local community. She has a strong commitment to making neuroscience content accessible and fun to children and young adults in the community, particularly to members of groups who are traditionally under-represented in the field. Through this work, she hopes to encourage more individuals, particularly women, to pursue a career in the STEMM fields.

  • Awards & Achievements

    Selected Professional Awards Received:

    • SA Young Tall Poppy Award, 2016 (Finalist: SA Tall Poppy of the Year)
    • SA Early Career STEM Educator of the Year, Tertiary Education, 2016
    • Executive Dean’s Award for Teaching Excellence, 2015
    • Unsung Hero of South Australian Science, Finalist, 2015
  • Teaching Interests

    Anatomy, Neuroanatomy, Neuroscience, Neuropathology, Neurological Disease

  • Research Interests

    Mechanisms underlying cognitive decline in healthy aging and neurodegenerative disease

    Role of neuroinflammation in Alzheimer's and Parkinson's disease

    Effect of novel electronic resources on student outcomes in neuroanatomy

  • Publications

    Google Scholar Profile:



    Corrigan, F. Arulsamy, A., Collins-Praino, L.E., Holmes, J.L., Vink, R. (2017). Toll like receptor 4 activation can be either detrimental or beneficial following mild repetitive traumatic brain injury depending on timing of activation. Brain, Beahaviour, Immunity, In press.

    Spinelli, J., Collins-Praino, L.E., Van Den Heuvel, C. and Byard, R. The evolution and significance of the triple-risk model in sudden infant death syndrome (SIDS). (2017). Journal of Pediatrics and Child Health, 53(2), 112-115. 

    Collins-Praino, L.E. and Corrigan, F. (2017). Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury? Brain, Behaviour and Immunity, 60, 369-382.

    Corrigan, F., Arulsamy, A., Teng, J., Collins-Praino, L.E. (2016). Pumping the brakes: Neurotrophic factors for the prevention of dementia following traumatic brain injury. J of Neurotrauma, 34(5), 971-986.

    Collins-Praino, L.E., Francis, Y., Griffith, E., Weigman, A., Urbach, J.A., Lawton, A., Honig, L.S., Cortes, E., Vonsattel, J.P.G., Canoll, P., Goldman, J.E. and Brickman, A.M. (In press). Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity. Acta Neuropathologica Communications.

    Brickman, A.M., Schupf, N., Manly, J.J. Stern, Y., Provenzano, F.A., Narkhede, A., Razlighi, Q.,Collins-Praino, L.E., Artero, S., Akbaraly, T., Ritchie, K., Mayeux, R. and Portet, F. (In press). APOE- ε4 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role? Alzheimer's & Dementia.

    Salamone, J.D., Podurgiel, S., Collins-Praino, L.E., Correa, M. (Forthcoming). “Physiological and behavioral assessment of tremor in rodents.” In: LeDoux, M.S. (Ed.), Movement Disorders: Genetics and Models (2nd ed.). Elsevier.

    Collins-Praino, L.E., Paul N.E., Ledgard F., Podurgiel S., Kovner R., Rhodes C., Hussain N., Baqi Y., Muller, C.E., Senatus P.B. & Salamone J.D. (2013). Deep brain stimulation of the subthalamic nucleus effectively reverses tremulous jaw movements induced by both dopamine antagonism and cholinergic stimulation in a rodent model of parkinsonian tremor: Interaction with the effects of adenosine A2A antagonism. European Journal of Neuroscience, 38(1), 2183-2191. 

    Podurgiel, S.J., Collins-Praino, L.E., Yohn, S., Lobianco, C., & Salamone, J.D. (2013). Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor. Pharmacology, Biochemistry, and Behavior, 105, 105-111.

    Salamone, J.D., Collins-Praino, L.E., Pardo, M., Podurgiel, S.J., Baqi, Y., Muller C.E., Schwarzschild, M.A., & Correa, M. (2012). Conditional neural knockout of the adenosine A(2A) receptor and pharmacological A(2A) antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor. EuropeanNeuropsychopharmacology, In press. (doi: 10.1016/j.euroneuro.2012.08.004)

    Collins-Praino, L.E., Podurgiel, S.J., Kovner, R., Randall, P. A., Salamone, J.D. (2012). Extracellular GABA in globus pallidus increases during the induction of oral tremor by haloperidol, but not by muscarinic receptor stimulation. Behavioral Brain Research, 234(1), 129-135.

    Santerre, J., Nunes, E.J., Kovner, R., Leser, C.E., Randall, P.A., Collins-Praino, L.E., Lopez Cruz, L., Correa, M., Baqi, Y., Muller, C.E., & Salamone, J.D. (2012). The novel adenosine A2A antagonist pro-drug MSX-4 is effective in animal models related to motivational and motor function. Pharmacology, Biochemistry, and Behavior, 102(4), 477-487.

    Collins-Praino, L.E., Paul, N.E., Rychalsky, K.R., Hinman, J.R., Chrobak, J.J., Senatus, P.B. & Salamone, J.D. (2011). Pharmacological and physiological characterization of the tremulous jaw movement model: Potential insights into the pathophysiology of tremor. Review. Frontiers in Systems Neuroscience, 5, 49.

    Collins, L.E., Sager, T.N., Sams, A.G., Pennarolla, A., Port, R.G., Shahriari, M. & Salamone, J.D. (2011). The novel adenosine antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacology, Biochemistry, and Behavior, 100(3), 498-505.

    Collins, L.E., Paul, N.E., Abbas S.F., Leser C.E., Podurgiel, S.J., Galtieri, D.J., Chrobak, J.J., Baqi, Y., Muller, C.E. & Salamone J.D. (2011). Oral tremor induced by galantamine in rats: A model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer’s disease. Pharmacology, Biochemistry, and Behavior, 99(3), 414-422.

    Salamone, J.D., Correa, M, Farrar, A.M., Nunes, E.J., & Collins, L.E. (2010).The role of dopamine/adenosine interactions in the brain circuitry regulating effort-related decision making: Insights in pathological aspects of motivation. Future Neurology, 5(3), 377-392.

    Sink, K.S., Segovia, K.N., Collins, L.E., Markus, E.J., Vemuri, V.K., Makriyannis, A., & Salamone, J.D. (2010). The Cb1 inverse agonist AM251, but not the Cb1 antagonist AM4113,  enhances retention of contextual fear conditioning in rats. Pharmacol Biochem Behav, 95(4), 479-484.

    Collins, L.E., Galtieri, D.J., Collins, P., Jones, S.K., Collins, P., Port, R.G., Paul, N.E., Hockemeyer, J., Muller, C., & Salamone, J.D. (2010). Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity. Behavioural Brain Research, 211(2), 148-155.

    Farrar, A.M., Segovia, K.N., Randall, P.A., Collins, L.E., Nunes, E.J., Stopper, C, Hockemeyer J, Muller, C, Correa, M, & Salamone, J.D. (2010). Nucleus accumbens and effort-related functions: Behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors. Neuroscience, 166(4), 1056-1067.

    Collins, L.E., Galtieri, D.J., Hockemeyer, J., Muller, C., & Salamone, J.D. (2010). Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. Pharmacology, Biochemistry, and Behavior, 94(4), 561-569. 

    Sink, K.S., Segovia, K.N., Sink, J., Collins, L.E., Correa, M, Markus, E.J., Vemuri, V.K., Makriyannis, A., & Salamone, J.D. (2010). Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142.  European Neuropsychopharmacology, 20(2), 112-122.

    Sink, K.S., Segovia, K.N., Nunes, E.J., Collins, L.E., Vemuri, V.K., Thakur, G., Makriyannis, A., & Salamone, J.D. (2009). Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology, 206(2), 223-232.

    Salamone, J.D, Farrar, A.M., Font, L., Patel, V., Schlar, D.E., Nunes, E.J., Collins, L.E., & Sager, T.N. (2009). Differential actions of adenosine A1 and A(2A) antagonists on the effort-related effects of dopamine D2 antagonism. Behavioural Brain Research, 201(1), 216-222.

    Mott, A. M., Nunes, E. J., Collins, L.E., Port, R.G., Sink, K.S., Hockemeyer, J., Muller, C., & Salamone, J.D. (2009). The adenosine A(2A) antagonist MSX-3 reverses the effects of the      dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure. Psychopharmacology (Berl), 204(1), 103-112.

    Collins, L. E. & Waldeck, R. F. (2006). Telencephalic ablation results in decreased acoustic startle avoidance behavior in goldfish. Brain Research, 1111, 162-165.

  • Professional Associations

    Australasian Neuroscience Society

    Australasian Cognitive Neuroscience Society

    Society for Neuroscience

    International Neurotrauma Society

    International Society for Neurochemistry

    International Basal Ganglia Society

  • Media Expertise

    CategoriesMedicine & Medical Research, Drugs
    ExpertiseNeuroscience; Alzheimer's disease; Parkinson's disease; ageing; Neuroanatomy; Neuropathology; cognition; inflammation; memory; prevention of cognitive decline; dementia; Immunology; Pharmacology; drug development; preclinical trials; cytokine; astrocyte; microglia; dopamine; acetylcholine; adenosine; hippocampus; basal ganglia; neurochemistry; neurotransmitter release; women in science; community outreach; university teaching

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Entry last updated: Sunday, 2 Aug 2020

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