Dr Martin Donnelley

Dr Martin Donnelley
 Position Senior Research Fellow
 Org Unit Paediatrics and Reproductive Health
 Email martin.donnelley@adelaide.edu.au
 Telephone +61 8 8161 9181
 Location Floor/Room G6 026 ,  WCH - Gilbert Building ,   Womens & Childrens Hospital
  • Biography/ Background

    Dr Martin Donnelley is a Robinson Research Institute Career Development Fellow working with the Adelaide Cystic Fibrosis Gene Therapy Research Group at the Women's and Children's Hospital, Department of Respiratory and Sleep Medicine. He is a Biomedical Engineer/Scientist that specialises in the use of medical imaging techniques for understanding respiratory disease.

    Martin joined the group in 2007 as a post-doctoral researcher on an NHMRC grant. Since that time his research has been focussed on using synchrotron X-ray light to image airway surfaces to quantify the effectiveness of gene therapy and pharmaceutical treatments for CF, specifically through non-invasive measures of mucociliary transit function.

    His research involves the creation of novel airway health measures for respiratory disease, as well as understanding how pollutants interact with the respiratory system. Martin holds an affiliate research fellow position in the Discipline of Paediatrics at the University of Adelaide.

  • Qualifications

    2007 - PhD, Flinders University

    2001 - BEng (Biomedical) with Honours, Flinders University

    2000 - BSc, Flinders University

  • Research Funding

    NHMRC

    Channel 7 Children's Research Foundation

    Australian CF Research Trust

    WCH Foundation

    Australian Synchrotron

    Robinson Research Institute (Travel grants: 2012-16)

  • Publications

    A. McCarron, M. Donnelley, C. McIntyre, D. Parsons, “Challenges of up-scaling lentivirus production and processing”, Journal of Biotechnology, Accepted for publication, 2016.

    K. Morgan, T. Petersen, M. Donnelley, N. Farrow, D. Parsons, D. Paganin, “Capturing and visualizing transient x-ray topological features by single-grid phase imaging”, Optics Express, vol. 24(21) pp. 24435-24450, 2016.

    M. Donnelley, K. Morgan, N. Farrow, R. Carnibella, R. Murrie, A. Fouras, D. Parsons, “Alteration of Mouse Nasal Airway Surface Mucociliary Transit by Airway Rehydrating Agents”, SPring-8 Research Reports, Accepted for publication, 2016.

    C. Stahr, C. Samarage, D. Parsons, M. Donnelley, N. Farrow, K. Morgan, G. Zosky, R. Boucher, K. Siu, S. Dubsky, A, Fouras, “Quantification of heterogeneity in lung disease with image-based pulmonary function testing”, Scientific Reports, vol. 6, 2016.

    M. Donnelley, K. Morgan, K. Siu, N. Farrow, D. Parsons, “Non-Invasive Airway Health Measurement Using Synchrotron X-Ray Microscopy of High Refractive Index Glass Microbeads”, AIP Conf. Proc. vol. 1696, 020011, 2016.

    R. Murrie, K. Morgan, A. Maksimenko, A. Fouras, D. Paganin, C. Hall, K. Siu, D. Parsons, M. Donnelley, “Live small animal x-ray lung velocimetry and lung micro-tomography at the Australian Synchrotron Imaging and Medical Beamline”, Journal of Synchrotron Radiation, vol. 22, 2015.

    P. Cmielewski, M. Donnelley, N. Farrow, C. McIntyre, J. Penny-Dimri, T. Kuchel, D. Parsons, “Transduction of Ferret Airway Epithelia by a Lentiviral Gene Vector”, BMC Pulmonary Medicine, vol. 14(183), 2014.

    P. Cmielewski, M. Donnelley, D. Parsons, “Long term therapeutic and reporter gene expression in lentiviral vector treated cystic fibrosis mice”, Journal of Gene Medicine, vol. 16(9-10), 291-299, 2014.

    K. Morgan, M. Donnelley, N.Farrow, A. Fouras, R. Boucher, N. Yagi, Y. Suzuki, A. Takeuchi, K. Uesugi, K. Siu, D. Parsons, “In vivo x-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis”, American Journal of Respiratory and Critical Care Medicine, vol. 190, pp 469-472, 2014.

    M. Donnelley, K. Morgan, K. Siu, A. Fouras, N. Farrow, R. Carnibella, D. Parsons, “Tracking extended mucociliary transport activity of individual deposited particles: Longitudinal synchrotron imaging in live mice”, Journal of Synchrotron Radiation, vol. 21, 2014.

    M. Donnelley, K. Morgan, K. Siu, N. Farrow, C. Stahr, R. Boucher, A. Fouras, D. Parsons, "Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo", Scientific Reports, vol. 4(3689), 2014.

    N. Farrow, D. Miller, P. Cmielewski, M. Donnelley, R. Bright, D. Parsons, “Airway gene transfer in a non-human primate: Lentiviral gene expression in marmoset lungs”, Scientific Reports, 2013.

    M. Donnelley, K. Morgan, K. Siu, D. Parsons, “Variability of in vivo fluid dose distribution in mouse airways is visualized by high-speed synchrotron x-ray imaging”, Journal of Aerosol Medicine and Pulmonary Drug Delivery, vol. 26(0), 1-10, 2013.

    K. Morgan, M. Donnelley, D. Paganin, A. Fouras, N. Yagi, Y. Suzuki, A. Takeuchi, K. Uesugi, R. Boucher, D. Parsons, K. Siu, “Measuring airway surface liquid depth in live airways by x-ray imaging for the assessment of cystic fibrosis airway therapies”, PLOS ONE, vol. 8(1), 2013.

    K. Morgan, D. Paganin, D. Parsons, M. Donnelley, N. Yagi, K. Uesugi, Y. Suzuki, A. Takeuchi, K. Siu, “Single grating x-ray imaging for dynamic biological systems”, AIP Proceedings, vol. 1466, pp. 124-129, 2012.

    M. Donnelley, K. Morgan, K. Siu, D. Parsons, “Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour”, Journal of Synchrotron Radiation, vol. 19, pp. 551-558, 2012.

    M. Donnelley, K. Siu, A. Jamison, D. Parsons, “Synchrotron phase contrast X-ray imaging reveals fluid dosing dynamics in mouse airways”, Gene Therapy, vol. 19, pp. 8-14, 2012.

    M. Donnelley, D. Parsons, K. Morgan, K. Siu, “Animals In Synchrotrons: Overcoming Challenges For High-Resolution, Live, Small-Animal Imaging”, AIP Proceedings, vol. 1266, pp. 30-34, 2010.

    M. Donnelley, K. Siu, K. Morgan, W. Skinner, Y. Suzuki, A. Takeuchi, K. Uesugi, N. Yagi, D. Parsons, “A new technique to examine individual particle and fibre deposition and transit behaviour in live mouse trachea”, Journal of Synchrotron Radiation, vol. 17, pp. 719-729, 2010.

    K. Morgan, D. Paganin, D. Parsons, M. Donnelley, N. Yagi, K. Uesugi, Y. Suzuki, A. Takeuchi, and K. Siu, “Optimising Coherence Properties for Phase Contrast X-Ray Imaging (PCXI) to Reveal Airway Surface Liquid (ASL) as an Airway Health Measure”, IFMBE Proceedings, vol. 25/II, pp. 135-138, 2009

    M. Donnelley, K. Morgan, A. Fouras, W. Skinner, N. Yagi, K. Uesugi, K. Siu, D. Parsons, “Real-time non-invasive detection of inhalable particulates delivered into live mouse airways”, Journal of Synchrotron Radiation, vol. 16, pp. 553-561, 2009.

    D. Parons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. Boucher, K. Uesugi, N. Yagi and K. Siu, “High Resolution Visualisation of Airspace Structures in Intact Mice via Synchrotron Phase Contrast X-ray Imaging (PCXI)”, Journal of Anatomy, vol. 213, pp 217-227, 2008.

    M. Donnelley, G. Knowles and T. Hearn “A CAD System for Long-bone Segmentation and Fracture Detection”, Image and Signal Processing. 3rd International Conference, ICISP, vol. 5099, pp 153-162, 2008

    M. Donnelley and G. Knowles, “Computer aided long bone fracture detection”, Proceedings of the Eighth International Symposium on Signal Processing and its Applications, vol. 1, pp 175-178, 2005.

    M. Donnelley and G. Knowles, “Automated Bone Fracture Detection”, SPIE Medical Imaging 2005: Image Processing, vol. 5747, pp 955-966, 2005.

    C. P. Rooney, M. Suter, G. McLennan, M. Donnelley, J. Reinhardt, A. Delsing, E. A. Hoffman, and J. Zabner, “Laser fluorescence bronchoscopy for detection of fluorescent reporter genes in airway epithelia”, Gene Therapy, vol. 9, pp. 1639-1644, 2002.

    D. Gopalakrishnan, G. McLennan, M. Donnelley, A. Delsing, M. Suter, D. Flaherty, J. Zabner, E. A. Hoffman, and J. M. Reinhardt, “Color analysis of the human airway wall”, SPIE Medical Imaging 2002: Physiology and Function from Multidimensional Images, vol. 4683, pp. 341-351, 2002.

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Entry last updated: Thursday, 7 Mar 2019

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