Ms Nicole McPherson
|Position||NHMRC Early Career Research Fellow|
|Org Unit||Paediatrics and Reproductive Health|
|Telephone||+61 8 8313 8201|
Adelaide Health and Medical Sciences
I'm an NHMRC Early Career Research Fellow and run the Sperm and Embryo Biology Research Group at the Robinson Research Institute and the Freemasons Centre for Mens Health. I also work in affiliation with the Monash IVF group. My main research interest include;
- Lifestyle and environmental factors of male fertility
- Paternal Programming of Childrens Health
- Clinical Andrology
- Sperm/egg Interactions and associated early embryo development
- Endangered Species Conservation
- 2011-2014 PhD (September, 2014), University of Adelaide
Title: The effect of diet and exercise for the treatment of male obesity induced sub fertility
- 2009-2010 Bachelor of Health Science Hons (1HA), University of Adelaide
Title: SIRT6 in spermatogenesis is modulated by diet induced obesity
- 2005-2007 Bachelor of Health Science (Reproductive Health & Genetics), University of Adelaide
Along with my clinical affiliates (Professor Michelle Lane (Science and Innovation, Monash IVF Group, Dr Dee Zander Fox (Regional Scientific Director, Monash IVF Group and Dr Tod Fullston Manager of Clinical Genetics, Repromed) I'm active in undergraduate teaching;
- Male reproductive Systems
- Clinical Andrology
I am always interested in recuriting high quality students for both honours and PhD studies in both animal models and clinical samples in the areas of;
- Male infertility
- Nutrition and sperm function
- Clinical biomarkers of pregnancy success via sperm
i) Scholarly book chapters
1. Fullston T, Shehadeh H, Schjenken J, McPherson NO, Robertson SA, Zander-Fox D and Lane M. Obesity: Intergenerational Programming and Consequences. Chapter 6. Paternal Obesity and Programming of Offspring Health. - Springer Publishing Company, New York, NY, USA. Editors LR Green & RL Hester. 2016, pp 105-131.
(ii) Refereed journal articles
2. Ferres K, McPherson NO, Lane M, Bakos H, Kind K and Breed WG. Gamete Cryopreservation of Australian Old Endemic Rodents – Spermatozoa from the Plains mouse (Pseudomys australis) and Spinifex Hopping mouse (Notomys alexis. Australian Mammology. 2017; accepted 6 April.
3. Mitchell M. Strick R, Strissel P, Dittrick R, Potabattula R, McPherson NO, Lane M, Pliushch G, Haaf T and El Hajj N. Gene expression and epigenetic aberrations in F1-placentas fathered by obese males. Molecular Reproduction and Development. 2017; accepted 7 Jan.
4. McPherson NO, Lane M, Sandeman LY, Owens JA and Fullston T. Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers. Nutrients; 2017; 9 (2), 122.
5. McPherson NO, Fullston T, Kang WX, Sandeman LY, Corbett MA, Owens JA and Lane M. Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers. Scientific Reports; 2016; Jun 3; 6:27010.
6. McPherson NO, Bell VG, Zander-Fox DL, Fullston T, Wu LL, Robker RL and Lane M. When two obese parents are worse than one! Impacts on embryo and fetal development. Am J Physiol Endocrinol Metab; 2015, 15; 309 (6): E568-81.
7. Fullston T, Shehadeh HS, McPherson NO, Sandeman L, Wu LL, Robker RL and Lane M. Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells. Journal of Assisted Reproduction and Genetics; 2015, 32(5):725-35.
8. McPherson NO, Owens JA, Fullston T and Lane M. Preconception diet or exercise interventions in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. Am J Physiol Endocrinol Metab; 2015, 1; 308 (9):E805-21.
9. McPherson NO and Lane M. Male obesity and sub-fertility, is it really about increased adiposity? Asian Journal of Andrology, 2015, May-Jun; 17(3):450-8.
10. Zander-Fox DL, McPherson NO and Lane M. Non-Genetic Inheritance, Fertility and Assisted Reproductive Technologies. Non-Genetic Inheritance; 2015, Volume 2, Issue 1.
11. Fullston T, McPherson NO, Owens JA, Sandeman L, Kang WK and Lane M. Paternal obesity induces metabolic and sperm disturbances in male offspring that is exacerbated by their exposure to an ‘obesogenic’ diet. Physiological Reports; 2015, 3(3), e12336.
12. Lane M, Zander-Fox DL, Robker RL and McPherson NO. Peri-conception parental obesity, reproductive health, and transgenerational impacts. Trends Endocrinol Metab; 2015, 26 (2):84-90.
13. Zander-Fox DL, Fullston T, McPherson NO, Sandeman L, Kang WX, Good S, Spillane M, and Lane M. Reduction of mitochondrial function by FCCP during mouse cleavage stage embryo culture reduces birth weight and impairs the metabolic health of offspring. Biology of Reproduction; 2015 92(5):124.
14. McPherson NO, Fullston T, Aitkens RJ and Lane M. Paternal obesity, interventions and mechanistic pathways to impaired health of offspring. Annals of Nutrition and Metabolism, 2014, 64:231–238.
15. Lane M, McPherson NO, Fullston T, Spillane M, Sandeman L, Kang WX and Zander-Fox DL. Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring. PLOS One, 2014, Jul 9;9 (7):e100832.
16. McPherson NO, Zander-Fox D and Lane M. Stimulation of mitochondrial embryo metabolism via dichloroacetic acid in an aged mouse model improves embryo development and viability. Fertility and Sterility; 2014, 101(5); 1458-1466.
17. McPherson NO, Fullston T, Bakos HW, Setchell BP and Lane M. An obese father’s metabolic state, adiposity and reproductive capacity indicate a son’s reproductive health. Fertility and Sterility; 2014, 101(3): 865-73.
18. Fulltson T, Teague EMO, Palmer NO, Deblasio MJ, Mitchell M, Corbett M, Print CG, Owens JA and Lane M. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB J; 2013, Oct vol: 7.
19. McPherson NO, Bakos HW, Owens JA, Setchell BP and Lane M. Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth’, PLOS One; 2013,8,8) e71459.
20. Palmer NO, Bakos HW, Fullston T and Lane M. Impact of Obesity on Male Fertility, Sperm Function and Molecular Composition. Spermatogenesis; 2012, 4 (2):1-11.
21. Fullston T, Palmer NO, Owens JA, Mitchell M, Bakos HW and Lane M. Diet induced paternal obesity in the absence of diabetes diminishes the reproductive viability of two subsequent generations of mice. Human Reproduction, 2012; 27(5):1391-400.
22. Palmer NO, Bakos HW, Owens JA, Setchell BP and Lane M. Diet and exercise in an obese mouse fed a high fat diet improves metabolic health and reverses perturbed sperm function. American Journal of Endo and Metabolism, 2012, Apr; 302(7):E768-80.
23. Palmer NO, Fullston T, Mitchell M, Setchell BP and Lane M. SIRT6 in mouse spermatogenesis is modulated by diet induced obesity. Reproduction Fertility and Development, 2012, Sep; 23 (7):929-39.
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Entry last updated: Monday, 29 Apr 2019
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