Professor Simon Barry

 Position Senior Research Fellow - PG Coordinator
 Org Unit Paediatrics and Reproductive Health
 Telephone +61 8 8161 6562
 Location Floor/Room 2 ,  WCH - Clarence Rieger Building ,   Womens & Childrens Hospital
  • Biography/ Background

    I am a molecular biologist studying the basis of immunological defects giving rise to autoimmune diseases such as type 1 diabetes. I am interested in regulatory T cells ( the policemen of the immune system), aiming to understand what genes drive their formation and their normal function with a view to developing novel cell and drug based therapies and diagnostic biomarkers. Specifically I wish to identify how the transcription factor FOXP3 regulates genes in the immune system, and I have also begun to investigate its role as a tumour suppressor. It is apparent that the molecular mimicry of tolerance mechanisms is a means by which solid tumours may evade immune detection. This reinforces the observation that tissues and systems strongly interact, and that global gene regulation plays a key role in disease progression.

  • Qualifications

    B.SC (Hons) Biochemistry (Kings College, London) 1988, Supervisor: Dr Paul Brown
    Ph.D (Kings College, London) 1991 Research carried out at the MRC National Institute for Medical Research, London. Supervisor Prof Colin Sanderson

  • Awards & Achievements

    1987-1991 MRC Postgraduate Scholarship
    1997-2000 Boehringer Ingelheim Postdoctoral Fellowship

  • Research Funding

    1. NHMRC Project Grant #399123; Barry, Shannon, D'Andrea, Zola
    ‘The molecular identification of FoxP3 +ve regulatory T cells.'

    NHMRC Project Grant #565314; Barry, Shannon, D'Andrea, Zola
    ‘Defining the functional role of FoxP3 target genes in human Treg formation and action.'
    2009-2011, $545,250.

    NHMRC Project Grant #626947 D'Andrea R, Ramshaw H, Barry SC
    Acute myeloid leukaemia: defining the role of the IL-3 receptor
    2010-12, $570,000 2011
    NHMRC Project Grant #1003185; Barry, Krumbiegel, Zola
    ‘PI16, a novel biomarker on human regulatory T cells.'
    2011-2013, $410,000.

    1. NHMRC Project Grant #1022326; Barry SC. McColl S
    FOXP3 regulated microRNAs: a novel component of FOXP3 tumour suppressor function in breast epithelial cells
    2012-14 $589,000

    2. NHMRC Project Grant #1021586; Barry SC. Schultze, J
    MicroRNAs: Critical regulators of Treg genes
    2012-14 $642,000

    NHMRC Project Grant #1041332; Robertson S, Barry SC, Print C
    Male-female sperm signalling - a novel pathway for peri-conceptual health?
    2013-15 $665,000

  • Publications

    21. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y and Goodall GJ: The microRNA-200 family and miR-205 regulate epithelial-mesenchymal transition by targeting the E-cadherin repressors, ZEB1 and SIP1. Nature Cell Biology 2009 10 (5)593-601 IF = 18.1, [28] JRK5/156

    22. Hutton JF, Gargett T, Sadlon TJ, Bresatz S, Brown CY, Zola H, Shannon MF, D'Andrea RJ, Barry SC, Development of CD4+CD25+FOXP3+ Regulatory T cells from Cord Blood Haemopoietic Progenitor Cells. Journal of Leukocyte Biology 2009 vol. 85 no. 3 445-451 IF = 4.3, JRK50/156

    23. Li S, Floess S, Hamann A, Gaudieri S, Lucas A, Hellard M, Roberts S, Paukovic G, Plebanski M, Loveland BE, Aitken C, Barry S, Schofield L, Gowans EJ. Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. PLoS Pathog. 2009 Dec;5(12)

    24. Nicola Leung, Nicholas Mabarrack, Angela Barbour, Adrian Cummins and Simon C Barry. Foxp3+ Regulatory T Cells, Th17 Effector Cells and Cytokine Environment in Inflammatory Bowel Disease. Clinical Immunolgy 2010 Jan;30(1):80-9.IF3.6

    25. Cheryl Y. Brown, Timothy Sadlon, Tessa Gargett, Elizabeth Melville, Rui Zhang, Yvette Drabsch, Craig A. Strathdee, Thomas J. Gonda, Simon C. Barry Robust, reversible gene knockdown using a single lentiviral shRNA vector Hum Gene Ther. 2010 30 1 80 - 89.

    26. Sadlon TS, Wilkinson BG, Pederson S, Brown CY, Bresatz S, Gargett T, Melville E, Peng K, Glonek G, Goodall GJ, Zola H, Shannon MF, Barry SC. Genome wide identification of human FOXP3 target genes in natural regulatory T cells J Immunol. 2010 Jul 15;185(2):1071-81. Epub 2010 Jun 16.

    27. Beyer M, Classen S, Lahl K, Thabet Y, Riley JL, Sadlon TJ, Schönfeld E, Flach A, Müller R, Basu S, Inhester T, Ciesla M, Gaarz A, Eggle D, Debey-Pascher S, End E, Knolle PA, Hippen KL, Blazar BR, Balderas R, Waha A, June CH, Quast T, Kolanus W, Schermer B, C Barry SC Sparwasser T, Schultze JL FOXP3-dependent repression of SATB1 ensures regulatory T-cell commitment Nature Immunology 2011 Aug 14;12(9):898-907.

    28. Škalamera, Dubravka, Ranall, Max V., Wilson, Benjamin M., Leo, Paul, Purdon, Amy S., Hyde, Carolyn, Nourbakhsh, Ehsan, Grimmond, Sean M., Barry, Simon C., Gabrielli, Brian and Gonda, Thomas J. (2011) A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One, 6 5: e20057.1-e20057.14

    29. McInnes N, Sadlon TJ, Brown CY, Pederson S, Beyer M, Schultze JL, McColl S, Goodall GJ, Barry SC FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells.
    Oncogene. 2011 Jul 11. doi: 10.1038/onc.2011.293

    30. Roberts-Thomson IC, Fon J, Uylaki W, Cummins AG, Barry SC Cells, cytokines and inflammatory bowel disease: a clinical perspective.. Expert Rev Gastroenterol Hepatol. 2011 Dec;5(6):703-16.

    31. Nicholson IC, Mavrangelos C, Bird DR, Bresatz-Atkins S, Eastaff-Leung NG, Grose RH, Gundsambuu B, Hill D, Millard DJ, Sadlon TJ, To S, Zola H, Barry SC, Krumbiegel D. PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. Cell Immunol. 2012 Jan;275(1-2):12-8.

    32. D Hill, N Eastaff- Leung, SBresatz- Atkins, N Warner, J Ruitenberg, D Krumbiegel, S Pederson, N McInnes, C Y. Brown, T Sadlon , S C Barry. Inhibition of activation induced CD154 expression on human CD4+ CD25- cells accurately reports suppressor function by human nTreg, iTreg and regulatory T cell lines.2012 Immunology and Cell Biology (2012) 90, 812-821

    33. Grose RH, Millard DJ, Mavrangelos C, Barry SC, Zola H, Nicholson IC, Cham W-T, Boros C, Krumbiegel D. Comparison of blood and synovial fluid Th17 and novel PI16 Treg cell subsets in juvenile idiopathic arthritis J Rheumatol 39.10 (2012): 2021-2031.

    34. Penno MA, Couper JJ, Craig ME, Colman PG, Rawlinson WD, Cotterill AM, Jones TW, Harrison LC and ENDIA Study Group: Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatrics 2013, 13:124.

    35. Jolley L, Holman C, Ruben J BarrySC, Gecz J. The UPF3B Gene, Implicated in Intellectual Disability, Autism, ADHD and Childhood Onset Schizophrenia Regulates Neural Progenitor Cell Behaviour and Neuronal Outgrowth. Human Molecular genetics In Press

  • Professional Associations

    External reviewer: Journal of Immunology, Blood,
    Human Gene Therapy, Gene Therapy, Molecular Therapy, Journal of Cellular and Molecular Medicine, Journal of Leukocyte Biology, Journal of Immunological Methods,
    Reviewer Faculty Fellowships, Faculty of Health Sciences, University of Adelaide 2006-

    Member Australasian Society for Immunology 2004-
    Member Australasian Gene Therapy Society 2004-8

    Member NHMRC GRP 1F 2010,2011
    Reviewer NHMRC project grants 2005,6,7
    Reviewer ARC discovery grants 2006, 7 (Oz reader 2009)

  • Community Engagement

    Member, Science twinning program Adelaide
    Interview for news item on stem cell research on Channel 9 news.
    Featured scientist, Australian Life Scientist, July 2013

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Entry last updated: Thursday, 9 Aug 2018

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