New SIDS research to study protein link

Wednesday, 13 June 2007

An Australia-first study led by the University of Adelaide could help identify the cause of Sudden Infant Death Syndrome (SIDS), one of the world's most tragic medical mysteries.

Paediatric pathologist Professor Roger Byard has launched a joint research project with the University of Aarhus in Denmark to study the presence of a protein found in some babies who have died from SIDS.

The project will investigate whether changes in brain levels of Amyloid Precursor Protein (APP) in infants may be a marker for potentially deadly breathing difficulties. APP is a protein which accumulates in the brain when there has been an injury to nerve fibres.

Professor Byard said the brain tissue of about 200 children who had died of the syndrome in Adelaide and Denmark would be tested for APP.

"Evidence that the protein is present in SIDS babies will not lead to a cure or a diagnostic test, but will help researchers understand the cause. It could also help prevent the syndrome recurring in the same family," he said.

"It will help us to understand why these children have died - because they may have trouble breathing and that's not been shown before - but it may also help families who have already had a SIDS death."

The University of Adelaide is one of the few centres in Australia which has looked at the presence of APP in SIDS babies.

Preliminary work by Professor Byard's team has recently been published in the American Journal of Forensic Medicine and Pathology, resulting in the commissioning of the ground-breaking research project.

Funded by SIDS and Kids SA, the innovative study is the first large scale collaborative project on SIDS between Australia and Europe.

"This is an excellent opportunity to do joint work between our two institutes that could have real importance not only in Europe and Australia, but for the rest of the world."

Professor Byard said that researchers now believed that SIDS was not just one disease, but was due to a whole series of different factors to which infants were predisposed. About one in 3000 babies dies of SIDS each year in Australia.


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Professor Roger Byard
School of Medicine
University of Adelaide

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